405-UNAGI: AI for Disease Progression and Drug Discovery

Paper Talk · Jan 18, 2026 · 15m

This research introduces UNAGI, a deep generative model designed to analyze cellular dynamics and facilitate in silico drug discovery for complex diseases like idiopathic pulmonary fibrosis and COVID-19. By combining a graph VAE-GAN architecture with gene regulatory network inference, the tool maps how cell populations transition across different stages of a disease. UNAGI distinguishes itself from previous methods by using an iterative training strategy that emphasizes disease-specific markers, improving the precision of cell embeddings. The model enables researchers to perform simulated…