466-Axes of Biological Variation in DLBC Lymphoma

Paper Talk · Feb 1, 2026 · 16m

This research article presents a multimodal single-cell atlas of diffuse large B cell lymphoma (DLBCL) to better understand the disease's molecular heterogeneity. By analyzing over 500,000 cells from 103 patient biopsies, the authors identified distinct gene expression signatures for established genetic subtypes and discovered that most tumors contain genetically diverse subclones. These subclones exhibit varying phenotypic themes related to cell growth, proliferation, and specific stages of B cell differentiation. The study highlights how specific genetic alterations, such as REL…