697-Whole-Brain Cell Atlas of Circadian Neural Activity

Paper Talk · Mar 26, 2026 · 21m

Researchers have developed a comprehensive single-cell atlas of the mouse brain to map how neural activity changes across the 24-hour circadian cycle. By using advanced tissue clearing and 3D imaging techniques on 144 brains, the study identified that nearly 80% of brain regions exhibit significant rhythmic patterns under constant darkness. The data reveals that while many areas peak during the animal's active night phase, others, such as those governing sleep and vision, activate during the day. This research highlights the spatiotemporal coordination of the entire brain, showing how…