531-Tau's Chemical Fingerprints Distinguish Dementias

Paper Talk · Feb 21, 2026 · 18m

Using the FLEXITau platform, researchers mapped 145 PTMs and 195 cleavage sites in human brains. Machine learning and mass spectrometry successfully classified six tauopathies, like Alzheimer’s, by their unique molecular signatures, offering new diagnostic and drug targets.

References:

Kumar M, Schlaffner C N, Tang S, et al. Molecular features of human pathological tau distinguish tauopathy-associated dementias[J]. Cell, 2026.

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