1172-Hypoxia-Driven Therapeutic Response in Metastatic ccRCC
This research examines how intratumoral hypoxia dictates the effectiveness and eventual resistance of VEGFR-TKI and immunotherapy combinations in clear cell renal cell carcinoma. By utilizing both transgenic mouse models and human patient cohorts, the authors discovered that while these treatments initially trigger beneficial tumor necrosis, prolonged exposure can paradoxically drive metastatic progression. A specific population of SPP1+ macrophages was identified as a critical indicator of true tissue hypoxia, serving as a biological proxy for therapeutic response. The study further…
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