Latest / The Bill Handel Show / GLP-1s | ‘Medical News’ with Dr. Jim Keany

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GLP-1s | ‘Medical News’ with Dr. Jim Keany · The Bill Handel Show

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Speaker 1: You're listening to KFI AM 640, the Bill Handel Show
0:04
Speaker 1: on demand on the iHeartRadio app.
0:07
Speaker 2: GLP-1s, that is something none of us knew anything about
0:11
Speaker 2: years ago, and now they're everywhere we look. I've talked
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Speaker 2: to many a doctor about the GLP-1s. I was on
0:19
Speaker 2: them for some time and quite curious about this drug
0:25
Speaker 2: and what it does and quite miraculous in a lot
0:28
Speaker 2: of ways. And although anything you put in your body,
0:31
Speaker 2: any medication has, you know, issues or things that you
0:37
Speaker 2: may deal with or others may deal with, those so-called
0:40
Speaker 2: side effects, they have been pretty amazing for a lot
0:47
Speaker 2: of people and they've helped a lot of people. But
0:51
Speaker 2: in the process of weight loss, and we've heard this forever,
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Speaker 2: You know, stupid, silly little machines, you know, from the
1:00
Speaker 2: 40s and those with the strap that would jiggle you.
1:04
Speaker 2: You remember seeing those in film and television? All it
1:07
Speaker 2: did was jiggle you or something. And I don't know,
1:09
Speaker 2: I was supposed to break down the fat or something.
1:11
Speaker 2: We've always had issues with weight loss. I certainly have
1:17
Speaker 2: in my mid 20s. When I stopped doing martial arts,
1:24
Speaker 2: fighting was my thing. I really loved sparring and all
1:28
Speaker 2: of that. And it's one of those things that is
1:30
Speaker 2: like chess to me. It's chess with consequences. And running
1:34
Speaker 2: bores me. Weightlifting was never my thing, although I went
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Speaker 2: through that phase just like most guys do. But they're finding...
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Speaker 2: that GLP-1s are rewriting the story of weight loss because
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Speaker 2: they're attaching them more and more with mental health. Now,
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Speaker 2: I will tell you straight up, man, I'm a fatty
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Speaker 2: because I stress eat. I eat when I'm happy. I
2:01
Speaker 2: eat when I'm sad. I eat when I'm thinking. Like
2:04
Speaker 2: I can't solve something, I go and I'll eat while
2:07
Speaker 2: I'm trying to get my brain to do what I
2:09
Speaker 2: want it to do. And as I get older, I
2:13
Speaker 2: learn more and more about how my brain wants to
2:15
Speaker 2: be treated. It's strange what it likes, what it doesn't like,
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Speaker 2: how foods or sleeping or whatever affect it and what
2:24
Speaker 2: things help. If you remember, Noom was real popular some
2:29
Speaker 2: time ago. Still is, I'm sure. Noom is a weight
2:31
Speaker 2: loss app. And when I was looking into that, I've
2:36
Speaker 2: since had bariatric surgery, had the sleeve done. When I
2:41
Speaker 2: was looking into that and when I look into all
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Speaker 2: these things, I'm always like, what is the mental part
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Speaker 2: for me? Because to me, it's mental issues. You know,
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Speaker 2: if you're way too skinny, you're way too heavy, there's
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Speaker 2: something going on. You're using it as something in your life, food.
3:01
Speaker 2: It's probably the number one health issue is how we
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Speaker 2: treat food in our lives. Well, Noom launched with things
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Speaker 2: like a mindful art break, encouraging you to go look
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Speaker 2: at art or see a piece of art or meditate.
3:17
Speaker 2: And meditation, I think, has a very powerful response or
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Speaker 2: your body has a very powerful response to meditation. And
3:27
Speaker 2: there can be a lot of good from that. But
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Speaker 2: seeing the overlap in weight and stress and self-care needs,
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Speaker 2: I think, is a powerful one. Whether it comes from,
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Speaker 2: you know, if you're taking the GLP-1, still understanding those
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Speaker 2: underlying core issues that make us want to eat. So
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Speaker 2: attaching these together is really opening up people's minds to
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Speaker 2: the fact that there's something in the feel-good part, mental part,
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Speaker 2: that ties into food. And to balance those things out
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Speaker 2: is where the key is. So more and more, as
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Speaker 2: you are looking into your identity, your body image, your
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Speaker 2: behavioral pairing, we're finding that your mind and your eating
4:13
Speaker 2: are a very strong partnership dealing with the food noise,
4:19
Speaker 2: quieting that food noise, quieting or curbing those cravings and
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Speaker 2: the mood effects that come with those things. So as
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Speaker 2: we are all kind of on our weight loss journeys
4:31
Speaker 2: or our weight journeys or bettering ourselves, don't forget to
4:35
Speaker 2: add that piece of the puzzle of wellness, as much
4:39
Speaker 2: as that's an overused word these days, but how much
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Speaker 2: wellness plays a part in whether that particular journey is
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Speaker 2: going to be successful or not. AI is top of
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Speaker 2: mind today for sure. And so there's been a lot
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Speaker 2: of stories about it. Here comes another one. And this
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Speaker 2: is the hands on the reign of the beast that
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Speaker 2: is AI. You've got OpenAI announcing that they're not going
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Speaker 2: to release, as expected, their new AI model called GPT
5:12
Speaker 2: 6.1 Astra. So they decided it didn't meet their safety standards. So,
5:17
Speaker 2: you know, we've been talking about this on and off
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Speaker 2: the air today about what are those safety standards going
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Speaker 2: to be? What are we even expecting? So We don't
5:27
Speaker 2: know a lot. They're not even telling us, you know,
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Speaker 2: something specific or what they're looking for. But we do
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Speaker 2: know they decided it didn't meet their safety standards. So
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Speaker 2: they're holding it back. And this comes out right before
5:41
Speaker 2: they were going to have this big developer conference. And
5:45
Speaker 2: that's a big deal. Could you imagine you have Apple?
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Speaker 2: We all know in September they have their big meetings
5:52
Speaker 2: at the new iPhones coming out. and they cancel or
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Speaker 2: the biggest thing that they were going to do, they
5:58
Speaker 2: stopped and said, we have some concerns. That would stop
6:02
Speaker 2: the bus. I think everybody would be like, what? So
6:06
Speaker 2: it is interesting, the timing. The company said that the
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Speaker 2: model had problems with staying within its limits and not
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Speaker 2: being clear enough with users about what it was doing.
6:17
Speaker 2: So that is vague, but it's enough. As much as
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Speaker 2: I'm not a fear monger, And concerned in that sense,
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Speaker 2: that doesn't make me feel great. They're like, yeah, it was,
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Speaker 2: you know, pushing beyond its limits. Like what? Did it
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Speaker 2: search something it shouldn't? Or did it, you know, turn
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Speaker 2: my toaster into a death machine? And that it wasn't,
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Speaker 2: that it knows enough to know not to maybe tell
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Speaker 2: the user what it was doing. It's also kind of interesting.
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Speaker 2: It's hiding.
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Speaker 3: Yeah.
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Speaker 2: Like I see a little kid there. What are you holding? Nothing.
7:01
Speaker 2: What are you holding? Nothing. Saatchi Jain, who's in charge
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Speaker 2: of the safety at OpenAI, by the way, she explained
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Speaker 2: that they have really high standards, one would hope, when
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Speaker 2: they release stuff to the public. I mean, it is living, breathing.
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Speaker 2: I mean, it's an entity at this point. So this decision,
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Speaker 2: they say, comes as a lot of people in the
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Speaker 2: AI world are getting worried about how fast these models
7:31
Speaker 2: are being developed. There used to be a pattern. It
7:34
Speaker 2: was about six months. Chips for computers, technology moved pretty quickly,
7:41
Speaker 2: about six months. I buy a lot of tech. My
7:46
Speaker 2: hobbies and my side company that I have builds things.
7:52
Speaker 2: So I have a lot of printers, different types of printers,
7:57
Speaker 2: CNC machines, laser cutters. And I will tell you, every
8:02
Speaker 2: time I buy the latest thing, within two weeks now,
8:07
Speaker 2: there is a new one that does things better. So
8:11
Speaker 2: this six-month mark used to be the mark. Well, you
8:15
Speaker 2: got six months ahead of the game, two weeks now.
8:18
Speaker 2: And sometimes by the same company. The same company puts
8:22
Speaker 2: out something within a couple of weeks of its newest, best,
8:26
Speaker 2: and greatest. So AI is making that timeline spin in
8:33
Speaker 2: its speed. And part of it is that they have
8:37
Speaker 2: put a choke on this stuff. You know, before we
8:42
Speaker 2: ever get it, they've got it. And sometimes for much
8:47
Speaker 2: longer than we know. And so this stuff comes out
8:50
Speaker 2: of this massive fire hose to us. And it's just
8:55
Speaker 2: when they look at it and say, it's moving too fast.
9:00
Speaker 2: So everybody's eyebrows are raised about AI. OpenAI and their
9:07
Speaker 2: rival company, Anthropic, going toe-to-toe on all this, recently said
9:12
Speaker 2: AI companies should slow down. And they're agreeing. You've got
9:16
Speaker 2: OpenAI CEO Sam Altman agreeing with that. Others agreeing with it.
9:21
Speaker 2: People are saying, yes, we have to, you know, you
9:23
Speaker 2: don't get everything all at once. We're used to technology
9:27
Speaker 2: moving at certain speeds. Last night, as I was looking
9:31
Speaker 2: through the news, I saw a news story on printed meat. Now,
9:40
Speaker 2: this is them using, this is actual cow meat. that
9:46
Speaker 2: they take the cells and they put them into a
9:48
Speaker 2: structure by way of a 3D printer, or sometimes they
9:52
Speaker 2: 3D print a scaffolding of sorts, and then it attaches
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Speaker 2: and it grows. I think the beginning of the Fork
10:01
Speaker 2: Report was maybe 16 years ago or something like that,
10:04
Speaker 2: and they were talking about that then, and this article
10:07
Speaker 2: is how it's going to be making its way into
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Speaker 2: markets and the like. That's 16 years or more with
10:16
Speaker 2: all that. That's kind of the technology. We hear these stories,
10:20
Speaker 2: news stories, and we go, oh, man, that sounds cool.
10:23
Speaker 2: I remember when I heard about Alexa for the first time,
10:27
Speaker 2: and I went on the list to buy one of
10:29
Speaker 2: the first ones because I was like, man, it's like
10:32
Speaker 2: a personal helper, and you could just ask it anything.
10:37
Speaker 2: And it took a while, but you get anxious. You're like,
10:39
Speaker 2: I want that thing to come out, right? And it
10:41
Speaker 2: took a little while, but it ended up coming out.
10:43
Speaker 2: Now they're everywhere. We got them stuck to the bottom
10:45
Speaker 2: of our shoes. They're in our phone. They're everywhere.
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Speaker 3: Car.
10:48
Speaker 2: But this is like every week. It's like, oh, you
10:51
Speaker 2: remember that funny video that we made of Will Smith
10:55
Speaker 2: eating spaghetti that looked weird? Well, now we can do
10:58
Speaker 2: it while he's reciting, you know, the Pledge of Allegiance
11:01
Speaker 2: standing on his head. And it looks real. And he's
11:03
Speaker 2: in space. So it's like it is moved. The technology,
11:09
Speaker 2: the amount that it moves, rather, is insane. They're non-comparative.
11:15
Speaker 2: When I put the new stuff next to the old stuff,
11:17
Speaker 2: it's like, oh, yeah, this is crap. So choking it
11:22
Speaker 2: a little bit is going to be necessary, and I
11:24
Speaker 2: think that's what we're seeing on this. We'll see what
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Speaker 2: comes the next time. What, because I said choking it? Seriously?
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Speaker 2: What are you, seven? First off. Don't look at me.
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Speaker 2: Ann started it. You looked at me. Ann, is that true?
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Speaker 2: I didn't do anything. I was listening.
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Speaker 1: It's a good story.
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Speaker 2: You guys just go to opposite corners for now. Think
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Speaker 2: about what you're doing. Dr. Jim Keeney, of course, is
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Speaker 2: with us as it is 830 on a Wednesday. Chief
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Speaker 2: Medical Officer for Dignity St. Mary Medical Center in Long Beach. Dr. Jim,
12:06
Speaker 2: what does a chief medical officer do?
12:08
Speaker 3: That's a good question. It's kind of all over the place, honestly.
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Speaker 3: I mean, everything from patient quality or patient care quality,
12:20
Speaker 3: patient safety, risk, And then we have a graduate medical
12:26
Speaker 3: education program that I oversee for internal medicine residency. Then
12:31
Speaker 3: there's the medical staff overall. I'm the kind of administrative
12:36
Speaker 3: half of the medical staff. They have a chief of
12:39
Speaker 3: staff that represents the actual doctors, and I'm the administrator
12:43
Speaker 3: that represents the hospital. But we're both doctors, so we
12:46
Speaker 3: can kind of connect on that level.
12:47
Speaker 2: Are you hands-on at all anymore?
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Speaker 3: Well, as far as seeing patients, no, I'm not on
12:52
Speaker 3: staff at St. Mary's, so I'm not actually a physician
12:55
Speaker 3: that sees patients there, but I am on staff at
12:57
Speaker 3: another hospital where I still work as an ER doctor
12:59
Speaker 3: every once in a while.
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Speaker 2: Oh, good. Keep those hands clean, all right? Yeah. Scientists,
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Speaker 2: they're growing stuff, this time a human cerebral cortex, and
13:11
Speaker 2: this is inside a live mouse?
13:14
Speaker 1: Yes.
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Speaker 3: Yeah, this is crazy. I just thought this was the
13:19
Speaker 3: craziest story, but it actually has a good use. You
13:22
Speaker 3: have to wait for the end to figure this out.
13:25
Speaker 3: The Stanford team, they genetically engineered mice, and then they
13:30
Speaker 3: kind of injected human brain cells into the mouse's brain,
13:37
Speaker 3: and they started growing. So much so that it replaced,
13:42
Speaker 3: like three months later, 90% of the cortical tissue was
13:47
Speaker 3: human-derived tissue, essentially. So human brain cells growing inside a mouse.
13:52
Speaker 3: So it's crazy. I think the first thing people think,
13:54
Speaker 3: the first thing I thought is, oh my gosh, are
13:55
Speaker 3: we making like sentient? mouse that now have human rights
14:01
Speaker 3: and human characteristics and can learn and grow. But no,
14:05
Speaker 3: that's not it at all. They did create groups of
14:09
Speaker 3: cells that were communicating, connecting, and working with the mouse.
14:12
Speaker 3: The mouse was almost indistinguishable from other mice. There were
14:17
Speaker 3: some coordination issues, but besides that, it was almost indistinguishable
14:23
Speaker 3: three months later. So what are we going to use
14:25
Speaker 3: this for? The key here is like this is the
14:29
Speaker 3: one area of the brain we can't do biopsies on.
14:31
Speaker 3: So if a kid, for example, has autism or somebody
14:34
Speaker 3: has Parkinson's or something like that, we want to get
14:38
Speaker 3: brain tissue under the microscope to look at. It turns
14:41
Speaker 3: out that we already know that we can turn a
14:45
Speaker 3: lot of your own cells into something like a stem cell.
14:48
Speaker 3: We call it a pluripotent cell. So we can basically
14:53
Speaker 3: take a skin cell, turn it into a pluripotent cell,
14:56
Speaker 3: put it in a mouse brain, let it grow as
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Speaker 3: a brain cell, and then take that out. and put
15:02
Speaker 3: it under the microscope, and now we have kind of
15:05
Speaker 3: an idea of what your brain cell looks like theoretically
15:08
Speaker 3: under a microscope. That's not what they're using it for yet, but,
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Speaker 3: I mean, this is one of the potential uses in
15:13
Speaker 3: the future. Wow.
15:15
Speaker 2: That's insane. That is absolutely insane.
15:20
Speaker 3: How much of these things are going?
15:21
Speaker 2: You know, you're reading journals all the time. Obviously, we're not.
15:25
Speaker 2: But how much of this stuff is going on on,
15:28
Speaker 2: you know, at any given time, this kind of crazy
15:31
Speaker 2: medical technology that we don't normally hear in the public.
15:36
Speaker 3: No, yeah, it's going on everywhere. I mean, genetics is
15:41
Speaker 3: an insane area as well. I mean, we're getting to
15:44
Speaker 3: the point where now we can make basically medications that
15:50
Speaker 3: are tailored to your DNA. We're not, again, we are
15:54
Speaker 3: there in some areas. We're not quite there yet as
15:57
Speaker 3: a mass treatment for the masses. But imagine that in
16:01
Speaker 3: the future, we just take a sample of one of your,
16:03
Speaker 3: you know, we scrape the inside of your cheek. and
16:05
Speaker 3: we get your DNA, and now we can tailor a medicine.
16:09
Speaker 3: Or we can figure out, you know, right now, again,
16:11
Speaker 3: in the brain, when we use things like antidepressants, it's
16:14
Speaker 3: hit or miss. We don't know which one's going to
16:16
Speaker 3: work on which person. You have to try it for
16:18
Speaker 3: three or four months to figure out if it works.
16:20
Speaker 3: And then three months later, you're like, okay, I'm still depressed.
16:23
Speaker 3: It doesn't work. Switch to another one. Average person takes
16:26
Speaker 3: three different changes to try and get on the right
16:30
Speaker 3: medicine or the right dose for the right combination of
16:33
Speaker 3: medication and doses imagine if we could just you know
16:37
Speaker 3: have some type of test like this that would show
16:39
Speaker 3: us your brain cell show the influence of these drugs
16:42
Speaker 3: and we'd be able to figure out without even you
16:44
Speaker 3: know doing all that to know which one will work
16:46
Speaker 3: which one won't yeah and as.
16:48
Speaker 2: It gets more bespoke i imagine that even side effects
16:51
Speaker 2: could change because you could modify something that would create
16:55
Speaker 2: a side effect in one person and not someone.
16:58
Speaker 3: Else yeah Exactly.
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Speaker 2: That's nuts. So Presley Gerber, I did not know who
17:06
Speaker 2: this person was, but I was intrigued by the story
17:11
Speaker 2: of the death and how this ties into– luxury sober
17:18
Speaker 2: living that we hear so much about when a famous
17:21
Speaker 2: person goes on some sort of jag and they end
17:24
Speaker 2: up in one of these places in malibu or whatever
17:28
Speaker 2: that have these unpleasant names what is this story and
17:31
Speaker 2: why did it capture your attention as a physician Yeah.
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Speaker 3: So, you know, in California, a lot of people don't
17:41
Speaker 3: know this, that you can have a group home of
17:45
Speaker 3: some kind up to six people can live there. You
17:47
Speaker 3: don't need a license or anything like that as long
17:51
Speaker 3: as it's just a place to live, essentially. So what
17:54
Speaker 3: they call these are sober livings, meaning a drug free
17:58
Speaker 3: group home. Those are allowed to just start up and
18:02
Speaker 3: pop up anywhere. And they are popping up in places
18:06
Speaker 3: that are very luxurious and charging exorbitant fees for people
18:10
Speaker 3: to live there in a sober environment. What they try
18:13
Speaker 3: and do is. I mean, maybe not all of them do,
18:16
Speaker 3: but to me, it seems like they're almost intentionally trying
18:20
Speaker 3: to confuse people with detox or rehab, which is very different.
18:26
Speaker 3: So detox is.
18:27
Speaker 2: Where you withdraw.
18:28
Speaker 3: That's where you're addicted to the medication. You're going through
18:31
Speaker 3: potentially life-threatening withdrawals. And you're given medications, you have vital
18:36
Speaker 3: signs taken, you know, there's you have a withdrawal scoring
18:40
Speaker 3: by licensed personnel. Then there's the actual like rehab facility
18:46
Speaker 3: and that provides residential addiction treatment that also requires a
18:52
Speaker 3: license because now you're getting counseling. You may be having
18:57
Speaker 3: continuing some level of detox, educational sessions, treatment planning, all
19:02
Speaker 3: those things. So that's a different level. And then sober living.
19:05
Speaker 3: It's only housing. That's all it is. You get a
19:08
Speaker 3: nice place with a great view and nobody's allowed to
19:12
Speaker 3: use drugs there. And that's really all they're selling. And
19:16
Speaker 3: that's I'm sure if you look at the fine print,
19:18
Speaker 3: that's all they claim. But it is confusing to the
19:20
Speaker 3: general public.
19:22
Speaker 2: Yeah, because what's licensed, what's not licensed. And, you know,
19:26
Speaker 2: you hear stories of. of treatment, how people are being
19:31
Speaker 2: treated or how they're allowed to interact or not interact
19:35
Speaker 2: with each other. And are they claiming that this particular
19:38
Speaker 2: location might not have been licensed properly in regards to
19:44
Speaker 2: Presley Gerber's death?
19:48
Speaker 3: Yeah, so what people are concerned about is were they
19:50
Speaker 3: aware that, because apparently, you know, I don't know anything
19:53
Speaker 3: about the specific facility, but apparently it was not licensed.
19:57
Speaker 3: So that would mean it would have to be at
19:59
Speaker 3: the level of a sober living or sober housing with
20:02
Speaker 3: no medical treatment, essentially. So was the family aware that
20:06
Speaker 3: even though it is a luxury sober living, that it
20:09
Speaker 3: really offers no withdrawal or detox or addiction treatment? It's
20:17
Speaker 3: not allowed to if it doesn't have a license. That's
20:19
Speaker 3: really the issue. And I see people in the emergency
20:23
Speaker 3: department all the time that come to these places from
20:26
Speaker 3: all over the country because they advertise everywhere and they'll
20:29
Speaker 3: try and pull people from places. They prefer people from
20:31
Speaker 3: out of state because it's actually harder for them to
20:33
Speaker 3: get out of the sober living. Some people try and
20:36
Speaker 3: run away from sober living because their family forced them
20:38
Speaker 3: in there. And if you're from Idaho and you're in California,
20:44
Speaker 3: then it's a lot harder to run away. So they
20:47
Speaker 3: get people from out of state quite often. They end
20:48
Speaker 3: up in the emergency room with no place to go.
20:51
Speaker 2: So what are the questions if you have– what are
20:55
Speaker 2: the questions that parents or family members should be asking
20:58
Speaker 2: or somebody– going into these houses to know?
21:02
Speaker 1: Yeah.
21:02
Speaker 3: So, yeah. So first you got to figure out, well,
21:04
Speaker 3: what are we withdrawing from? You know, alcohol is much
21:09
Speaker 3: different than narcotics, which can be much different than other drugs. So,
21:14
Speaker 3: you know, is this actually a rehab facility? Is it
21:17
Speaker 3: licensed by the state? What's it licensed for? Is it
21:19
Speaker 3: licensed for detox rehab? What who's physically present, especially overnight that,
21:25
Speaker 3: you know, do they just leave everybody behind? in the
21:28
Speaker 3: building overnight? Are there people there? Are there licensed personnel
21:31
Speaker 3: like nurses or clinicians or counselors there? These are the
21:35
Speaker 3: kind of questions that you would want to ask. And
21:37
Speaker 3: if it is alcohol or benzodiazepine, those withdrawals are a
21:42
Speaker 3: little more dangerous. So benzodiazepines are like Valium because both
21:47
Speaker 3: of those can quickly become life-threatening. So you want to
21:51
Speaker 3: know specifically, can they manage either of those if that's
21:54
Speaker 3: part of what you're going in for?
21:56
Speaker 2: God, that's scary. Yeah, I've never seen withdrawals personally. Thank God,
22:03
Speaker 2: never seen anybody that's had that that I'm aware of,
22:06
Speaker 2: but they sound scary as hell.
22:10
Speaker 3: Yeah, and overall, right, the biggest overall thing is don't
22:13
Speaker 3: mistake luxury for quality rehab, right? You can have a
22:17
Speaker 3: very luxury building, but it's not necessarily a quality rehab facility.
22:22
Speaker 2: That's an excellent point, Doc. All right, Dr. Jim Keeney,
22:25
Speaker 2: it's always nice to talk to you, Doc. I appreciate
22:27
Speaker 2: the insights there. Chief Medical Officer for Dignity, St. Mary
22:31
Speaker 2: Medical Health Center there in the LBC. Have a great week, sir,
22:36
Speaker 2: and we'll talk again.
22:37
Speaker 3: All right, you too.
22:39
Speaker 1: Take care.
22:39
Speaker 2: All right, folks, thanks so much. I'll be back tomorrow
22:41
Speaker 2: morning with the morning crew. We'll see you then. Stick
22:44
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