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Reviving Vancomycin to Fight Superbugs | Science News
Scientists have revived a powerful old antibiotic, vancomycin, by pairing it with a small molecule called pghi-four that blocks a key bacterial enzyme responsible for resistance. This breakthrough, led by Professor John Moses, could make existing drugs effective again against superbugs like drug-resistant E. faecium — without needing to invent new antibiotics. Using a novel chemical method called diversity oriented clicking, they screened over 150 compounds and found pghi-four’s ability to shut down SagA, restoring vancomycin’s power. The strategy offers a promising blueprint for tackling…
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