1602-Microbial Integration Patterns in Melanoma

Paper Talk · Sep 23, 2026 · 22m

A meta-analysis of three clinical trials reveals that the success of fecal microbiota transplantation (FMT) in boosting melanoma immunotherapy depends on stable donor strain integration rather than simple bacterial diversity. Researchers discovered that patients who responded to anti-PD-1 therapy exhibited resilient gut communities that successfully adopted donor microbes and enriched metabolic pathways. In contrast, non-responders experienced significant microbial load fluctuations and an increase in pro-inflammatory pathobionts following the transplant. These ecological shifts in the gut…