559-Tumour–Brain Crosstalk Restrains Cancer Immunity
Recent scientific research explores how neural pathways between the brain and peripheral organs regulate the progression of solid tumors, specifically focusing on lung cancer. The study identifies a sensory-sympathetic axis where the brain detects tumors via vagal sensory neurons and subsequently triggers a response through the sympathetic nervous system. This biological communication suppresses the immune system by promoting arginase-expressing macrophages and inhibiting the activity of protective T cells. Researchers demonstrated that disrupting this brain-body circuit or using…
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