831-Spatial Tumor Evolution Panorama of Ovarian Cancer

Paper Talk · Apr 21, 2026 · 22m

This research outlines a comprehensive spatial tumor evolution panorama of high-grade serous ovarian cancer using the innovative STARLETS framework. By integrating whole-genome sequencing, single-cell RNA-seq, and spatial transcriptomics, the authors illustrate how hypoxia and immune pressure drive a Darwinian selection of malignant clones that eventually metastasize. The study identifies a unique tripartite ensemble consisting of SPP1+ macrophages, MMP11+ myCAFs, and epithelial cells that facilitate cancer spread within the peritoneal cavity and ascites. Experimental evidence shows that…