1424-Somatic Kitl Facilitate Meiotic Prophase I

Paper Talk · Aug 12, 2026 · 22m

This scientific article demonstrates that Kitl/Kit signaling between somatic granulosa cells and germ cells is essential for the initiation and progression of meiosis in female mouse embryos. By utilizing conditional knockout models and single-cell RNA sequencing, the researchers found that a lack of Kitl leads to significant defects in homologous synapsis, DNA repair, and crossover formation during prophase I. The study reveals that this regulation occurs through the activation of the mTOR pathway, which is driven by p-AKT signaling within the fetal germ cells. Experimental results show that…