Latest / Stuff You Should Know / Selects: Maggots: Good For Healing Wounds, Turns Out
Transcript
- 0:00Speaker 1: Hello there, it's Josh and for this week's S Y
- 0:03Speaker 1: s K Selex, I've chosen maggots colon good for healing wounds.
- 0:07Speaker 1: Turns out, uh, and that is absolutely true. Um, I
- 0:11Speaker 1: really listened to all of our select episodes, and I
- 0:14Speaker 1: listen to this one, and I'm clearly excited in the episode.
- 0:18Speaker 1: But I was just as excited listening to it all
- 0:21Speaker 1: these years later, but five years after we released it. Um,
- 0:24Speaker 1: So I hope it excites you. It is groty, but
- 0:27Speaker 1: it's also pretty awesome. So enjoy slash prepared to be
- 0:31Speaker 1: grossed out. Welcome to Stuff you should know, a production
- 0:38Speaker 1: of My Heart Radios How Stuff Works. Hey, and welcome
- 0:47Speaker 1: to the podcast. I'm Josh Clark. There's Charles W. Chuck Bryant,
- 0:52Speaker 1: and uh, no one, no one else is in here
- 0:54Speaker 1: with us yet again, because we've graduated to the point
- 0:57Speaker 1: where we don't even need a producer. We need so
- 1:00Speaker 1: body who presses record and leaves Yep, that's it, because
- 1:03Speaker 1: we're pros Yep, not p R O s E. P
- 1:08Speaker 1: R Oh that's right, we're not. But we are prosaic, yes,
- 1:12Speaker 1: but definitely not p r O apostrophees. Very few things
- 1:16Speaker 1: drive me crazier than that. And I know it's stupid
- 1:18Speaker 1: and pedantic, but to see, like somebody take out a
- 1:21Speaker 1: huge billboard or something and so a word has an
- 1:25Speaker 1: apostrophe that shouldn't prose. People say, like, leave it to
- 1:28Speaker 1: the pros and they'll put an apostrophe. Yes, and it's
- 1:32Speaker 1: it's that graphic designer should be, you know, doctor half
- 1:36Speaker 1: a day's paying maybe eight bucks. Something we want to
- 1:41Speaker 1: issue and you probably would get this from the title
- 1:43Speaker 1: of the episode, but we want to issue a meal warning.
- 1:47Speaker 1: Oh good thinking, because we've gotten complaints in the past
- 1:50Speaker 1: when people are eating and get sick listening to some
- 1:52Speaker 1: of these, Yeah, this would do it possibly for some people.
- 1:55Speaker 1: I was fine, I ate a runny yolk egg sandwich
- 1:59Speaker 1: while I white writer. Yeah right, it didn't bother me,
- 2:03Speaker 1: but I could totally see how it could be any people.
- 2:06Speaker 1: I also want to say, um, if it comes up,
- 2:09Speaker 1: do not go Google image search wound sloth. Well, I
- 2:13Speaker 1: just put do not Google image search maggot therapy at all. Okay, sure,
- 2:18Speaker 1: but definitely stay away from wound sloth s l o
- 2:21Speaker 1: U g H. Yeah, wow, it definitely don't look at
- 2:27Speaker 1: wound slough while you're eating. Yeah, okay, so that's all
- 2:32Speaker 1: out of the way. Yes, I predict we're going to
- 2:34Speaker 1: be kind of excited about this one. I'm feeling a
- 2:36Speaker 1: little pumped about it. Well, we did cover in uh
- 2:39Speaker 1: tin bizarre medical treatments uh leech therapy, which is still
- 2:43Speaker 1: being used, and I'm surprised this wasn't in that article.
- 2:46Speaker 1: To be honest, I am as well. But this gets
- 2:48Speaker 1: its own special deal, and well it should actually because
- 2:51Speaker 1: it's a pretty amazing thing. Um, we're talking about maggot therapy. Also,
- 2:57Speaker 1: by the way, yes it is they were awesome so
- 2:59Speaker 1: or they really or is it a band name? Well,
- 3:01Speaker 1: it's a band name to end all band names. There
- 3:04Speaker 1: probably was a band name that, So there's it's called
- 3:06Speaker 1: maggot therapy, maggot debridement therapy, larval therapy, or bio. There's
- 3:13Speaker 1: another one called I think like bio biodebridement or therapeutic
- 3:19Speaker 1: wound misses. Yeah, and that's basically all the all of them,
- 3:26Speaker 1: no matter what you call it, no matter how you
- 3:28Speaker 1: church it up. It is the application of live maggots
- 3:33Speaker 1: fly larva to purposefully to an open wound in order
- 3:38Speaker 1: to help that wound heal. Faster and better and cleaner
- 3:42Speaker 1: and everything. Dat punk said, Oh yeah, you know, should
- 3:50Speaker 1: we talk about some of the history of this stuff.
- 3:52Speaker 1: Let's just say that one more time. Okay. Maggot debridement
- 3:56Speaker 1: therapy is taking live maggots and put getting them in
- 4:00Speaker 1: an open wound on a human being or an animal.
- 4:03Speaker 1: It's used in veterinary medicine as well, wrapping it up
- 4:05Speaker 1: tight and letting them just eat the dead and dying
- 4:09Speaker 1: flesh of that wound while you get your foot tickled. Okay,
- 4:14Speaker 1: I would be so skiped out by this. I just
- 4:16Speaker 1: wanted to make sure that everybody knows exactly what we're
- 4:18Speaker 1: talking about, right, and goodbye to everyone everyone who fainted. Okay, Yeah,
- 4:24Speaker 1: let's talk about the history, chuck, because this is um.
- 4:26Speaker 1: This is in use today, but it's actually pretty old. Yeah,
- 4:30Speaker 1: I mean it's it's some say it's an even an
- 4:32Speaker 1: ancient tradition, like in places like Burma in Central America
- 4:37Speaker 1: with the Mayan's um. They were smart enough to know
- 4:40Speaker 1: that maggots do a pretty good job of consuming human flesh. Uh,
- 4:45Speaker 1: and it can be used for good in that regard. Yeah,
- 4:48Speaker 1: at some point I guess healers noticed like yef. People
- 4:51Speaker 1: who had maggots in their wounds tended to have wounds
- 4:54Speaker 1: heal U. And actually, as far as the Western literature goes,
- 4:58Speaker 1: that's exactly how um maggot therapy first finds its way,
- 5:02Speaker 1: first crawls into the medical literature is from a French
- 5:07Speaker 1: surgeon named Ambro Ambras Poare. Yeah, but how would you say,
- 5:14Speaker 1: I don't know, I don't speak French Ambras even though
- 5:20Speaker 1: it doesn't have the little what is that an accent? Yeah,
- 5:23Speaker 1: it's just the e. But he was a sixteenth century
- 5:26Speaker 1: surgeon and he noticed that, um, that people didn't necessarily
- 5:32Speaker 1: fall over dead if there was a maggot in the wound. Yeah.
- 5:34Speaker 1: He was the first doctor to actually come out and say,
- 5:37Speaker 1: you know, I had this patient with a big skull wound,
- 5:41Speaker 1: and unbeknownst to me, there were maggots in there. I
- 5:44Speaker 1: saw them crawling out one day. And even though they
- 5:46Speaker 1: had a lot of bone. Um, the guy was great.
- 5:49Speaker 1: He healed like he lost a hand sized slab of
- 5:53Speaker 1: skull and he lived. And I think it might have
- 5:56Speaker 1: something to do with the maggots. And he presumably were
- 5:59Speaker 1: a helmet for the us of his life. Probably he
- 6:01Speaker 1: had a probably big soft skull there, I guess so. Uh.
- 6:06Speaker 1: That was followed in uh with the mid seventeen hundreds
- 6:10Speaker 1: by another Frenchy baron, Dominique Jean Laoie uh, and he said,
- 6:17Speaker 1: you know what, on this Egyptian expedition, Uh, these blue
- 6:21Speaker 1: fly maggots are actually doing the right thing and helping
- 6:25Speaker 1: us out. So it's almost like these doctors just noticed
- 6:28Speaker 1: this exactly and it meant enough to him that they
- 6:32Speaker 1: were like, I should probably write this down. This is
- 6:34Speaker 1: going to be my great contribution to medical history of
- 6:37Speaker 1: the history of science, right. Um. So it wasn't until
- 6:42Speaker 1: the uh, I guess, the Civil War that a doctor
- 6:46Speaker 1: actually said I'm going to purposefully put maggots in a
- 6:49Speaker 1: wound and see what happens. And that doctor was John
- 6:52Speaker 1: Forney Zacharias. He probably didn't tell his patient that. I
- 6:56Speaker 1: think probably that he was just like, just bite down
- 6:58Speaker 1: on this brooms and the other way. Do you want
- 7:01Speaker 1: to lose your foot or do you want to try
- 7:02Speaker 1: something really weird? Well, supposedly in studies of people, modern
- 7:07Speaker 1: patients who are offered this therapy say yes to it. Well, yeah,
- 7:11Speaker 1: because I think that's what it comes down to. You
- 7:12Speaker 1: it's a last resort. Basically, it's not the first thing
- 7:15Speaker 1: they offer, not necessarily. Um So, Anyway, doctor Zacharias um
- 7:21Speaker 1: Hey had a great quote. He said, during my service
- 7:23Speaker 1: in the hospital at Danville, Virginia, I first used maggots
- 7:26Speaker 1: to remove the decayed tissue in Hospital Gang Green, and
- 7:30Speaker 1: with my eminent satisfaction, in a single day, they would
- 7:33Speaker 1: clean a wound much better than any agents we had
- 7:36Speaker 1: at our command. I used them afterwards at various places.
- 7:39Speaker 1: I am sure I saved many lives by their use,
- 7:41Speaker 1: escaped sept to semia, and had rapid recoveries period. End quote.
- 7:46Speaker 1: Pretty great. Yeah. So he was a huge believer and
- 7:49Speaker 1: not just a passive observer like people who came before him.
- 7:52Speaker 1: He said, Yeah, I put maggots on wounds and it helps,
- 7:56Speaker 1: That's right. And uh, people experimented with it for a
- 7:58Speaker 1: little while until um a guy named Louis Pasteur and
- 8:02Speaker 1: Robert Coke came along, uh microbiologists and germ theorists that
- 8:07Speaker 1: basically said, you know, this is this is disgusting. We
- 8:12Speaker 1: might want to not do this. Yeah, because they're dirty.
- 8:14Speaker 1: Yeah yeah, and it's true. Maggots naturally in the wild
- 8:18Speaker 1: carry lots of pathogens with them that UM can infect
- 8:22Speaker 1: us in other ways, can make a wound worse, can
- 8:24Speaker 1: actually kill you. So this the idea behind germ theory
- 8:27Speaker 1: as far as maggots goes. Right. But UM, it seems
- 8:32Speaker 1: like there's this long history of necessity and disgusted with
- 8:37Speaker 1: maggot therapy that kind of wayne ebbs and flows right,
- 8:40Speaker 1: and necessity rears its head on the battlefield. It did
- 8:44Speaker 1: in the Civil War, and it also did in World
- 8:46Speaker 1: War One. There was a surgeon UM named William S.
- 8:50Speaker 1: Bayer and he was working on the front lines in France,
- 8:53Speaker 1: and he used maggots on stomach wounds and open fractures,
- 8:58Speaker 1: and he found, to his great satisfaction, just like Dr
- 9:02Speaker 1: Zacharias and the other before him, that this stuff actually worked. Yeah,
- 9:05Speaker 1: And he actually said, you know what, I have some
- 9:08Speaker 1: further advancements. UM, maybe we should put a bandage over
- 9:11Speaker 1: this thing so it doesn't completely discussed the patient. Uh,
- 9:15Speaker 1: And let me UM put bandages around the wound, so
- 9:20Speaker 1: they don't start creeping onto the healthy flesh and doing
- 9:23Speaker 1: damage or just itching you or creeping you out further
- 9:26Speaker 1: right exactly, UM, which are still in use today. These techniques.
- 9:29Speaker 1: He also pioneered another huge technique, and this is after
- 9:33Speaker 1: the war was over. Ten years later, when he was
- 9:36Speaker 1: back at Johns Hopkins UM. He he pioneered another really
- 9:39Speaker 1: important technique, and that was using sterilized um maggots. Like
- 9:44Speaker 1: germ free maggots. They were raised as eggs in a
- 9:48Speaker 1: sterile environment and so when they were introduced to the wounds,
- 9:51Speaker 1: they weren't carrying these pathogens anymore. And he found this
- 9:55Speaker 1: is the jackpot. Now you can use maggots from now on.
- 9:59Speaker 1: That's right. And there was a big boom in the
- 10:01Speaker 1: thirties up until the mid nineteen forties. Uh, three more
- 10:05Speaker 1: than three hundred American hospitals. Uh, we're using maggot treatment,
- 10:10Speaker 1: maggot therapy. And then in uh antiseptics came along, or
- 10:15Speaker 1: you know, new antiseptics and they said, you know what,
- 10:17Speaker 1: maybe there was another lull in the use of maggot theory. Right,
- 10:20Speaker 1: Necessity didn't didn't spur this stuff, and it was they
- 10:23Speaker 1: went back to just being gross again. There was a
- 10:25Speaker 1: guy um who by the eighties wrote what what this
- 10:29Speaker 1: one article calls the majority opinion. Fortunately, maggot therapy is
- 10:33Speaker 1: now relegated to a historical backwater of interest more for
- 10:37Speaker 1: its bizarre nature than its effect on the course of
- 10:39Speaker 1: medical science. A therapy the demise of which no one
- 10:42Speaker 1: is likely to mourn. That's just that kind of Western
- 10:46Speaker 1: medicine hubris, where like we can do anything except everything,
- 10:52Speaker 1: you know. Uh, that's right. And in the nineteen nineties, UM,
- 10:57Speaker 1: a dude named Ronald Sherman and Edward peck Or basically
- 11:01Speaker 1: champion the technique again and kind of brought it into
- 11:06Speaker 1: the modern age. Yeah, and still very much is. Um.
- 11:09Speaker 1: Ronald Sherman is one of the first, I think, to
- 11:13Speaker 1: receive a license to produce sterile maggots for use as
- 11:18Speaker 1: medical devices. Um. And there's another guy over in uh
- 11:23Speaker 1: the UK named John Church um who who brought the
- 11:28Speaker 1: maggot their maggot therapy into the four So it was
- 11:33Speaker 1: an ancient thing, it was. It's found to be disgusting,
- 11:37Speaker 1: it's found to be useful, it's found to be disgusting,
- 11:40Speaker 1: it's found ways you can make it better. It's found
- 11:43Speaker 1: to be disgusting. And then now that this idea of
- 11:46Speaker 1: complimentary medicine is is kind of regaining some traction again. UM,
- 11:51Speaker 1: I think it's here to stay. Though I think so too,
- 11:54Speaker 1: unless someone comes along in ten years is you know
- 11:57Speaker 1: what it's disgusting, Well, you know the chuck. I mean
- 11:59Speaker 1: probably what we're seeing is the next thing that will
- 12:01Speaker 1: happen is there will be some huge leaps, some huge
- 12:04Speaker 1: development in science, and science will get its tackles up
- 12:06Speaker 1: again and great about itself and we don't need any
- 12:09Speaker 1: of that stupid nastiness. And then we'll find that Nope,
- 12:13Speaker 1: you still can't beat good old fashioned maggots. And that's
- 12:16Speaker 1: that should be the title of this thing. You can't
- 12:18Speaker 1: beat good old fashioned maggots for healing a wound that
- 12:21Speaker 1: won't heal otherwise. It's a great title. So you want
- 12:24Speaker 1: to take a break, Uh, yeah, let's do it, and
- 12:27Speaker 1: we'll go um treat our own wounds and we'll be
- 12:30Speaker 1: back shortly. All right, Let's talk about diabetes for a second. Yeah,
- 13:04Speaker 1: more than twenty three million Americans are affected with diabetes.
- 13:09Speaker 1: And one thing that can happen, uh is nerve damage,
- 13:13Speaker 1: especially in the extremities the hands and feet and the
- 13:17Speaker 1: toes and the and the fingers. Your blood vessels become
- 13:20Speaker 1: hard and they don't circulate the blood like you need.
- 13:23Speaker 1: That can lead to open sores called ulcers, which can
- 13:27Speaker 1: become infections, which can spread to nearby bone, which can
- 13:31Speaker 1: lead to amputation. Yeah, and all of all this is
- 13:34Speaker 1: just from a prolonged exposure to high levels of blood
- 13:37Speaker 1: sugar and they're not sure how it can do it.
- 13:39Speaker 1: But yeah, the blood, the blood vessels not helping pump
- 13:42Speaker 1: blood very well get nutrients or your tissue can die.
- 13:45Speaker 1: But also that neuropathy that dead and nerves cell um
- 13:49Speaker 1: that actually makes it hard for you to notice. If
- 13:52Speaker 1: you have like a really bad ulcer on the bottom
- 13:55Speaker 1: of your foot, you can't feel it. Yeah, and so
- 13:57Speaker 1: you don't get treatment early enough, so it can get
- 13:59Speaker 1: an infection, can get out of hand, and when it
- 14:02Speaker 1: spreads to bone that's called osteo myelitis. That's problematic because
- 14:07Speaker 1: that very quickly will lead to an amputation. And there's
- 14:10Speaker 1: some pretty shocking stats here from this article that Tom wrote,
- 14:14Speaker 1: Um about this sheave jam Yeah nice, it's yeah for sure, Um,
- 14:19Speaker 1: But about amputations from diabetes, Yes, seventy thousand to foot
- 14:24Speaker 1: and leg amputations each year in the United States alone,
- 14:28Speaker 1: and uh they say around the world, they estimate every
- 14:31Speaker 1: thirty seconds someone gets a limb cut off because of diabetes. Yeah,
- 14:36Speaker 1: that's sad. Yeah, it really is, and we should. We
- 14:38Speaker 1: will do one on diabetes for sure. Oh yeah, I'm
- 14:41Speaker 1: surprised we haven't already. Um. But the so amputation is
- 14:48Speaker 1: used to halt the progress of an infection, and that's
- 14:52Speaker 1: usually the last resort. But what's what Tom points out
- 14:55Speaker 1: is that there are plenty of doctors around the world
- 14:59Speaker 1: I imagine that aren't aware that you can use maggots
- 15:03Speaker 1: or have ever done it before. And if you are
- 15:06Speaker 1: facing an amputation from say like a wound, a persistent wound,
- 15:10Speaker 1: a chronic wound that won't heal, Um, you may want
- 15:13Speaker 1: to suggest maggots to your doctor. You may have to
- 15:15Speaker 1: actually take this the the initiative on this one and say,
- 15:20Speaker 1: let's make sure the amputation is the absolute last resort.
- 15:23Speaker 1: Let's see if we can put one more resort in
- 15:25Speaker 1: there before then I'm willing to let maggots crawl inside
- 15:28Speaker 1: my body in this wounds open wound if you're willing
- 15:32Speaker 1: to apply them. And they uh, like most doctors love
- 15:36Speaker 1: hearing when patients suggest treatments. Oh they do. They love feedback.
- 15:40Speaker 1: They love to be guided in their diagnoses and prognoses. Yeah,
- 15:45Speaker 1: I love it. That's a tough jam. I get it.
- 15:47Speaker 1: Doctors are frustrated a lot of these days with self
- 15:50Speaker 1: diagnosis and online doctoring. But you should also be your
- 15:53Speaker 1: own advocate. We can't be in that before. Yeah it's
- 15:56Speaker 1: your leg. Yeah you want to keep your leg. You
- 15:58Speaker 1: tell that doctor to go get some maggots. You're going
- 16:00Speaker 1: to replace them with the doctor who will. I can
- 16:03Speaker 1: find a guy, Yeah, I can get a guy by
- 16:05Speaker 1: noon that'll put maggots on that wound. And actually there's
- 16:07Speaker 1: a there's a group I think Ronald Sherman, the guy
- 16:10Speaker 1: we mentioned earlier who's like the the US champion of
- 16:14Speaker 1: maggot therapy. UM. It's there's this group called the B
- 16:18Speaker 1: Turf Foundation B T e Er Foundation, UM, and they
- 16:22Speaker 1: have all sorts of resources for people in that very situation,
- 16:26Speaker 1: like how to talk to your doctor, UM that if
- 16:30Speaker 1: your insurance won't cover it, let them know, because they
- 16:33Speaker 1: say insurance actually most insurance covers maggot therapy, but most
- 16:37Speaker 1: insurance claims people are not aware of that, so you
- 16:41Speaker 1: may get denied at first. And here's how to talk
- 16:43Speaker 1: to your insurance company. That's it really is. That beats
- 16:46Speaker 1: going to your doctor and saying well, you know what
- 16:48Speaker 1: Josh and Chuck said. He you're not gonna like hearing this,
- 16:52Speaker 1: right because you think you know it all doctor, please
- 16:55Speaker 1: take a sleep and be put maggots on my feet, right.
- 16:58Speaker 1: And and that's the other thing too, I mean, like
- 17:01Speaker 1: we wouldn't be suggesting this and the Better Foundation probably
- 17:04Speaker 1: wouldn't be such advocates for it if it didn't work
- 17:07Speaker 1: so amazingly. Well, it's study after study, and we'll talk
- 17:13Speaker 1: about the details of it, but there's so many studies
- 17:16Speaker 1: out there. Um Again. Sherman, who agreed, is an advocate,
- 17:20Speaker 1: but in a pure reviewed journal published a survey of
- 17:23Speaker 1: studies that he could find on maggot therapy, and it's
- 17:26Speaker 1: very clear that it works really really well, and not
- 17:30Speaker 1: only necessarily um as a means of last resort, but
- 17:34Speaker 1: even just compared to the standard of care using like
- 17:38Speaker 1: hydrogell or other things that you might use to treat
- 17:40Speaker 1: a chronic wound. Maggots destroy it, They leave it in
- 17:44Speaker 1: the dust. Yeah. And if it doesn't work, it's not
- 17:46Speaker 1: gonna hurt anything. Yeah. Yeah, it just puts off how
- 17:50Speaker 1: much longer before they amputate your foot? Pretty much? Yeah.
- 17:54Speaker 1: Uh so what will happen is they will Well, let's
- 17:56Speaker 1: get into this a little bit. Um, there are four
- 17:59Speaker 1: differ friend, and you where did you find this? Was
- 18:01Speaker 1: this a a research paper? Yeah? This is by Ronald
- 18:05Speaker 1: Sherman Mechanisms of maggot induced wound healing colin What do
- 18:09Speaker 1: we know and where do we go from here? It
- 18:12Speaker 1: was in the journal Evidence Based, Complimentary and Alternative Medicine
- 18:15Speaker 1: in two thousand and fourteen, that's right, And he describes
- 18:18Speaker 1: four different phases of basically healing a wound um homeostasis, inflammation, ploriferate. Man,
- 18:26Speaker 1: I'm so bad at that one. Oh yeah, keep it coming, proliferation,
- 18:32Speaker 1: nice going, and uh remodeling and maturing. And what happens
- 18:36Speaker 1: is the cells get to work, they recruit other cells,
- 18:39Speaker 1: they alter their activities and basically say, let's get to
- 18:42Speaker 1: work cleaning and uh, well on all four of these
- 18:47Speaker 1: stages to help heal the wound. Yeah, and at any
- 18:51Speaker 1: any one of those stages, Um that the next process
- 18:55Speaker 1: can stall out. Um. Normally it stalls out at inflamation
- 19:00Speaker 1: ation because the infection gets out of hand in the
- 19:02Speaker 1: body can't fight off the infection faster than it's laying
- 19:07Speaker 1: The extracellular matrix for the new cells to be rebuilt,
- 19:11Speaker 1: the new tissue to recro um. And that's that's it's
- 19:14Speaker 1: a common thing that leads to chronic wounds. Yes, they
- 19:17Speaker 1: just won't heal. And that's where maggots are really really
- 19:20Speaker 1: useful to basically interrupt that stall and get the car
- 19:24Speaker 1: moving again in the right direction. It's exactly right, they
- 19:26Speaker 1: kick started. Uh. So debridemant is removing dead tissue, and
- 19:31Speaker 1: that is really where maggots excel um. They said, Uh,
- 19:36Speaker 1: in here, each maggot can chew, Well they don't exactly chew,
- 19:39Speaker 1: which we'll get to. Uh. They remove twenty five milligrams
- 19:43Speaker 1: of necrotic material dead flesh, uh, in just twenty four hours. Yeah,
- 19:47Speaker 1: that's pretty good. Yeah, and uh, there's there's actually three
- 19:51Speaker 1: ways that maggots clean a wound. But debridement, which is
- 19:54Speaker 1: getting in there and like just cleaning out, removing physically
- 19:58Speaker 1: removing um that dead material. That's like the key that
- 20:02Speaker 1: seems to be the key. And then there's also um
- 20:05Speaker 1: anti microbial activity like actually killing the bacteria that's killing
- 20:10Speaker 1: the flesh, leaving it cleaner than when they came in, Yeah,
- 20:13Speaker 1: which is amazing. And then even more astounding stimulating new growth,
- 20:19Speaker 1: like the act the presence of maggots in your wound
- 20:23Speaker 1: stimulates new tissue growth around your skin. It's the most
- 20:28Speaker 1: they're just like wonder creatures who knew. One of the
- 20:33Speaker 1: ways that they remove this dead tissue is just by
- 20:37Speaker 1: the nature of what their body is like. And they
- 20:40Speaker 1: have these little prickly spines all over their body that
- 20:44Speaker 1: act as a surgeon's rasp rasper or file what It
- 20:48Speaker 1: Basically just the fact that they're moving around on the
- 20:51Speaker 1: wound is going to like file the stuff down and
- 20:55Speaker 1: scrape the wound, which helps loosens it up. It's like
- 20:58Speaker 1: a plow. It burrows through this dieing and dead tissue
- 21:01Speaker 1: and it just, yeah, it loosens up. That's part one
- 21:04Speaker 1: of derived Part one. There's another part of it, which
- 21:07Speaker 1: is the digestive enzymes that they excrete and secrete. It's
- 21:11Speaker 1: called alimentary secretions and excretions a s C. It's basically
- 21:15Speaker 1: they're digestive juices, right, and they puke these up as
- 21:18Speaker 1: they're moving around and they just they just puke them
- 21:22Speaker 1: everywhere and it dissolves this flesh. Yeah. I remember in
- 21:26Speaker 1: the Body Farms episode we we talked about this one
- 21:29Speaker 1: one of the old classics. And that's why I said earlier.
- 21:32Speaker 1: They don't bite or choose something. They just liquefy it
- 21:36Speaker 1: and then suck it in. And this this A s
- 21:38Speaker 1: C stuff is so greedy that it liquefies more dead
- 21:42Speaker 1: flesh than the maggots can even consume, and they consume
- 21:46Speaker 1: quite a bit, Like you said, twenty five milligrams. That's
- 21:49Speaker 1: a lot for a little tiny maggot in one day.
- 21:52Speaker 1: But even more than that, they're liquefying even more of
- 21:54Speaker 1: this dead tissue. So that part of the process of
- 21:58Speaker 1: maggot debridemant therapy is draining out this liquefied necrotic tissue
- 22:04Speaker 1: that's become liquefied from the alimentary or the the A
- 22:09Speaker 1: s C stuff. The digest events ons, right, So you've
- 22:11Speaker 1: got them burrowing around, you've got them puking into your wound,
- 22:16Speaker 1: liquefying the dead tissue, leaving pretty much entirely the living
- 22:21Speaker 1: tissue alone, and then you just kind of drain out
- 22:25Speaker 1: the stuff that's that's in there. And the reason um
- 22:29Speaker 1: that maggots are considered by the FDA a medical device
- 22:33Speaker 1: rather than a drug is because the whole process of
- 22:37Speaker 1: dibrid mint isn't just a reaction to the chemicals. It
- 22:40Speaker 1: is part of that mechanical movement of the maggots through
- 22:43Speaker 1: the wound. So it's a drug, it's a device. I
- 22:46Speaker 1: mean it's a device. Look at them, yea, and those
- 22:51Speaker 1: that the secretions are so potent. They have basically DNA
- 22:57Speaker 1: destroying qualities, Like they not only just break down tissue,
- 23:02Speaker 1: they destroy the d N A. It's pretty amazing stuff
- 23:06Speaker 1: it is. Should we take another break? Yeah, I'm a
- 23:09Speaker 1: little excited. We probably should. Alright, I'm gonna go to
- 23:11Speaker 1: the vomitorium. Are you grossed out slightly? I am not
- 23:16Speaker 1: in the least. What does that say about me? I
- 23:20Speaker 1: don't know. You have a stronger stomach, but I don't necessarily,
- 23:23Speaker 1: I'm I'm just excited. All right, we'll go watch me
- 23:25Speaker 1: vomited at least. Okay, that will gross me out? All right?
- 23:48Speaker 1: Well that was disgusting, it was It made me throw
- 23:50Speaker 1: up in turn. Uh So here's a couple of questions. Um,
- 23:57Speaker 1: does it hurt? Maybe a little bit at first. Yeah,
- 24:01Speaker 1: I don't get the feeling that it's extremely painful. It
- 24:04Speaker 1: probably depends on the wound. Um, but it can the
- 24:07Speaker 1: first few treatments can apparently be a little bit painful, right,
- 24:10Speaker 1: And there's there's actually two mechanisms for the pain. One
- 24:13Speaker 1: is that an open wound, right, and you have maggots
- 24:17Speaker 1: crawling over the exposed nerves in your open wound. That's
- 24:20Speaker 1: not gonna feel good, No, it won't. Uh. And then
- 24:22Speaker 1: number two, pressure in the wound can increase as the
- 24:25Speaker 1: maggots get bigger from eating so much dead flesh. That's right.
- 24:29Speaker 1: So yes, the the the cure to that is pain killers, which, frankly,
- 24:33Speaker 1: if you have an open wound with exposed nerves, you
- 24:36Speaker 1: should probably be on those anyway. Sure you will be,
- 24:38Speaker 1: so it probably won't hurt because there'll be some sort
- 24:41Speaker 1: of pain management going on, but you will still feel
- 24:45Speaker 1: most likely unless the doctor completely numbs the area maggots
- 24:49Speaker 1: crawling around inside the wound. See, that's what That's the
- 24:52Speaker 1: part that gets me is actually thinking about undergoing this
- 24:56Speaker 1: therapy myself is what gets me, not like seeing it
- 24:59Speaker 1: or reading about it, but thinking about having an open
- 25:02Speaker 1: wound on the bottom of my foot and having maggots
- 25:04Speaker 1: creeping around in there. See. The thing is I think
- 25:07Speaker 1: anybody would feel that way. There's very few included myself.
- 25:10Speaker 1: I'm not grossed out by this, but I wouldn't want
- 25:12Speaker 1: maggots talking wound. But I think if your backs against
- 25:15Speaker 1: the wall, uh that, or you lose your foot, I try.
- 25:20Speaker 1: I would definitely try. I think as people would apparently
- 25:23Speaker 1: man and I would demand some high quality drugs. And
- 25:27Speaker 1: they also have um what is it called amnesiotics to
- 25:32Speaker 1: make you forget about so you can't form memories while
- 25:35Speaker 1: it's happening. So maybe that would be a nice thing
- 25:37Speaker 1: to do too. So the other question is can you
- 25:40Speaker 1: just use any kind of maggot and the answer is no.
- 25:43Speaker 1: What they found is the most useful is the larva
- 25:46Speaker 1: of the green blow fly. And like we said earlier,
- 25:49Speaker 1: these things are now grown just sort of like the
- 25:52Speaker 1: medical leeches there shipped and sterile containers, uh as if
- 25:56Speaker 1: it were medicine, even though it's a device. And the
- 25:59Speaker 1: B T. E. R. Foundation they go into a lot
- 26:03Speaker 1: about this like could anybody do this? And they say, well, no,
- 26:06Speaker 1: because you need a prescription. It's an FDA control yourself.
- 26:10Speaker 1: But they say anybody who can read can basically follow
- 26:15Speaker 1: the instructions on the package. I wouldn't, I mean, I
- 26:19Speaker 1: wouldn't advise that as your non doctor. Sure, I'm not
- 26:22Speaker 1: saying that either, but I mean this may be your
- 26:24Speaker 1: doctor's first time to their Their point was is it's
- 26:28Speaker 1: not it's not difficult. Just follow the instructions on the packet.
- 26:31Speaker 1: If you win. Your doctor though, he got the maggots
- 26:34Speaker 1: out and he put on his bifocals and was like,
- 26:36Speaker 1: all right, let's see how to do this right or
- 26:38Speaker 1: like he tears the package open. They go everywhere you have,
- 26:41Speaker 1: like Jerry Lewis as a doctor. Uh oh. But although
- 26:46Speaker 1: they do say, um, you can't just load it up
- 26:48Speaker 1: with maggots. There should be no more than eight maggots
- 26:50Speaker 1: per square centimeter. Yeah, I saw five to eight. And
- 26:54Speaker 1: so when you have the maggots applied to your um wound,
- 26:59Speaker 1: they're going to make sure that the healthy area around
- 27:02Speaker 1: the wound is covered up so the maggots can't get
- 27:04Speaker 1: to it, which goes back to World War two. Yeah,
- 27:07Speaker 1: they're going to cover it, cover up the wound after
- 27:10Speaker 1: they apply the maggots five to eight per square centimeter,
- 27:12Speaker 1: like you say, and they're going to cover it up
- 27:14Speaker 1: so they can't wander off because maggots like to leave
- 27:17Speaker 1: before their work is done. Um TV, they're full pretty much, um,
- 27:23Speaker 1: but they can still eat more if you'll keep them
- 27:25Speaker 1: in there so they will cover up. They'll put the
- 27:28Speaker 1: maggots in five to eight cover it up with this
- 27:30Speaker 1: bandage and basically they will just sit there and eat
- 27:33Speaker 1: for between forty eight and seventy two hours, and then
- 27:38Speaker 1: the bandage will be removed. The maggots will then sadly
- 27:42Speaker 1: be incinerated or put into an autoclave or put into
- 27:47Speaker 1: a plasma gas of fire, or bronzed and hung on
- 27:51Speaker 1: your wall for real, like an ant farm. Yeah, because
- 27:54Speaker 1: it's like, thank you for this great contribution to saving
- 27:58Speaker 1: my foot, Now go be autoclave today. I would name
- 28:02Speaker 1: them and save them and preserve them. Um, you'd be
- 28:06Speaker 1: violating I'm sure all sorts of medical waste laws, but
- 28:09Speaker 1: who cares and so and then that's that's what's called
- 28:12Speaker 1: the treatment cycle. And most patients UH supposedly go between
- 28:17Speaker 1: two and four treatment cycles. And again, while this is happening,
- 28:22Speaker 1: what's going on is the maggots are debriding the dead flesh,
- 28:25Speaker 1: they're liquefying it, they're eating it, and they're also disinfecting
- 28:29Speaker 1: it and stimulating growth. Right, pretty amazing. So with the
- 28:33Speaker 1: with this, with the disinfecting, they figured that there was
- 28:37Speaker 1: some sort of gut flora that the maggots have that
- 28:41Speaker 1: prevents them from being infected by micropoil. That would make
- 28:45Speaker 1: sense because they're in that riting flesh as well and
- 28:47Speaker 1: they're thriving, right, So what gives Well, it turns out
- 28:50Speaker 1: that there are a couple of um types of I'm
- 28:54Speaker 1: not quite sure what what kind of um bacteria they are,
- 28:58Speaker 1: but they are. Oh that's not true. The proteus mirabilious
- 29:03Speaker 1: is a type of symbiotic microbe that you find in
- 29:06Speaker 1: the gut of a maggot, right, And this thing just
- 29:10Speaker 1: destroys microbial life. So it's killing the bacteria that's causing
- 29:14Speaker 1: this infection in your wound. But there's something that that maggots.
- 29:18Speaker 1: This is yet another thing. So think about it, Chuck,
- 29:20Speaker 1: Like you said, maggots, The very structure of a maggot
- 29:24Speaker 1: body dibrides the wound. That's amazing. This maggot anti microbial
- 29:29Speaker 1: stuff not only does it kill microbes, it destroys the
- 29:32Speaker 1: thing that naturally protects microbes, which is called biofilm. Yeah,
- 29:36Speaker 1: we've talked about biofilm a lot on this show, and um,
- 29:39Speaker 1: it's basically it's basically a film, like a literal film,
- 29:44Speaker 1: like a They call it a polymeric matrix. But the
- 29:47Speaker 1: easiest way to say in Layman's terment is it's a film, right,
- 29:50Speaker 1: It's like a protective coding. Yeah. And the little spiny bodies,
- 29:53Speaker 1: like one way they get rid of the thing is
- 29:55Speaker 1: by roughing it up, And that's exactly what the little
- 29:57Speaker 1: bodies do, right, And that's part of surgical I've meant
- 30:00Speaker 1: with like um, like going in there and scrubbing a
- 30:03Speaker 1: wound um with I don't know, steel wool or something
- 30:07Speaker 1: like that that will break up the biofilm. It's also
- 30:10Speaker 1: must be awfully painful, right. Maggots naturally can destroy not
- 30:15Speaker 1: just the bacteria but also the biofilm that protects it
- 30:18Speaker 1: to which makes them extremely handy with things like MERSA
- 30:22Speaker 1: and other antibiotic resistant um bacteria and all kinds of ulcers, right,
- 30:29Speaker 1: not like internal ulcers, but the open wound kind right,
- 30:32Speaker 1: exactly from diabetes, from bed sores um. And there's been
- 30:36Speaker 1: a lot of studies of people with bed sores that
- 30:38Speaker 1: have found that maggots help those kind of ulcers tremendously,
- 30:42Speaker 1: so Uh, let's talk about this one study or a
- 30:44Speaker 1: couple of studies. Actually, UM, there was one study of
- 30:48Speaker 1: spinal cord injury patients that had non healing ulcers, which
- 30:52Speaker 1: is the problem. And they monitored them over three to
- 30:55Speaker 1: four weeks UM, and they were getting regular wound care
- 30:58Speaker 1: at the same time, like sometimes it's used in conjunction
- 31:01Speaker 1: I think usually is used in conjunction with like standard care. UH.
- 31:05Speaker 1: And they found that uh, after three or four weeks
- 31:09Speaker 1: of maggot therapy, tissue quality and wound size were ressessed
- 31:12Speaker 1: weekly and they found that debridement was achieved in less
- 31:16Speaker 1: than fourteen days an average of ten days, and none
- 31:19Speaker 1: of the control group wounds were more than fifty dibrided
- 31:22Speaker 1: after a month. A month, not even half dibrided. None
- 31:26Speaker 1: of the wounds, not half the wounds were divided, None
- 31:29Speaker 1: of the wounds were even half dibrided after a month
- 31:32Speaker 1: chuck of the control group. Yes, amazing where they didn't
- 31:34Speaker 1: use the maggots. Yes, that's that's objectively amazing. It is.
- 31:40Speaker 1: And then they did a larger clinical trial and found uh,
- 31:43Speaker 1: this time they got two hundred and sixty three subjects,
- 31:46Speaker 1: which is pretty good for this kind of rare treatment
- 31:48Speaker 1: for uh. And they found that um, using the hydrogel
- 31:52Speaker 1: which you mentioned earlier, compression dressings, just the standard care,
- 31:58Speaker 1: that was the control. Yeah, that's obvious. The control. They
- 32:01Speaker 1: differed significantly between the three groups. Um, what was the
- 32:05Speaker 1: third group? The third group used bio bags, which are
- 32:07Speaker 1: like it's like a little pouch. You said it was
- 32:09Speaker 1: like a rav healthy Yeah, and it's filled with live maggots,
- 32:13Speaker 1: but it prevents them from burrowing. All it is is
- 32:15Speaker 1: using their chemical secretions. Yeah, I don't That to me
- 32:19Speaker 1: is just like why go halfway? Right? Exactly? Well, a
- 32:22Speaker 1: lot of people are like, I don't want a maggot
- 32:24Speaker 1: crawling in my wound, but a bag of them is
- 32:27Speaker 1: fine doing the shake shake near my wound. Right. So, um,
- 32:31Speaker 1: it actually has been shown to be not nearly as
- 32:33Speaker 1: effective as just letting what's called free range maggots burrow
- 32:37Speaker 1: through the wound. So they found the media time for
- 32:40Speaker 1: debryment was fourteen days with free range, twenty eight days
- 32:43Speaker 1: with the bagged ravioli, and seventy two days for the control.
- 32:48Speaker 1: Yeah that's pretty amazing. Yeah, Like, I I don't know,
- 32:52Speaker 1: I don't think it should be a last resort. You know,
- 32:55Speaker 1: I agree, and I think that increasingly it's becoming less
- 32:58Speaker 1: and less of the last resort because I mean, you
- 33:00Speaker 1: can compare it to the control, Like the standard of
- 33:03Speaker 1: care took seventy two days for the wound to be divided,
- 33:07Speaker 1: free range maggots fourteen days. That to me says that
- 33:10Speaker 1: free range maggots top the standard of care as it
- 33:13Speaker 1: stands right now. But like you say, there's a lot
- 33:16Speaker 1: of people who are saying this is just a last resort.
- 33:19Speaker 1: The next thing we're gonna do is amputate your foot.
- 33:21Speaker 1: But let's try this one last time. Or in the
- 33:24Speaker 1: case of persistent infections from like MERSA, where just antibiotics
- 33:28Speaker 1: just don't work, let's let's try maggots and see if
- 33:32Speaker 1: we can fix it. And maggots do work. There was
- 33:34Speaker 1: a study that found that of thirteen people treated who
- 33:38Speaker 1: had MERSA treated with maggots alone, twelve of the thirteen
- 33:43Speaker 1: had complete recovery and wound healing um from a mercer infection.
- 33:49Speaker 1: Mercu's nasty stuff too. Yeah, I think did we do
- 33:51Speaker 1: what I'm MERSA. I feel like we did. I know
- 33:55Speaker 1: we've talked about it. I don't know if it got
- 33:57Speaker 1: its own show though may have been in the should
- 33:59Speaker 1: we outlaw anti bacterial soap episode? Well, there's been a
- 34:04Speaker 1: lot of them, almost eight hundred. Uh you got anything else?
- 34:12Speaker 1: Surely I do, but I guess not. Um. Oh yeah,
- 34:18Speaker 1: Well there's one other thing we kept kind of teasing it.
- 34:21Speaker 1: It actually stimulates growth. A couple of studies have found
- 34:25Speaker 1: that the presence of maggots um produce more blood vessel
- 34:31Speaker 1: redevelopment and tissue redevelopment than maggots not being present. So
- 34:37Speaker 1: something about them actually stimulates tissue growth and blood vessel growth,
- 34:41Speaker 1: which promotes wound healing even more. Up with maggots. Up
- 34:45Speaker 1: with maggots, indeed, Man, I love them. I'm so psyched
- 34:48Speaker 1: about maggots right now. Well, it definitely changes the way
- 34:51Speaker 1: you think about them. Like, next time you see a
- 34:53Speaker 1: the dead squirrel that you've killed, they're clearly trying to
- 34:58Speaker 1: bring it back to life. Yeah, and you see the
- 34:59Speaker 1: maggot you can. You don't think that's disgusting. You just
- 35:02Speaker 1: think those are little things doing their thing, doing their thing.
- 35:06Speaker 1: Little things doing their thing. Now I'm going to autoclave them,
- 35:09Speaker 1: that's right. Uh. If you want to know more about
- 35:11Speaker 1: maggot therapy, you can type those words in the search
- 35:14Speaker 1: bar at how stuff forks dot com. And since I
- 35:17Speaker 1: said search parts time forward listener, I'm gonna call this
- 35:23Speaker 1: taken to task somewhat over a term. Guys, I want
- 35:28Speaker 1: to say you are my favorite podcast by far. I've
- 35:30Speaker 1: been listening since you were just a little five minute blurbs.
- 35:34Speaker 1: Oh man, you sure have grown up. I've never written
- 35:37Speaker 1: in before, but felt a head to comment on Josh's
- 35:39Speaker 1: statement that climate change was for global warming was settled science. No,
- 35:44Speaker 1: I'm not disputing the data that shows an increase in
- 35:46Speaker 1: global temperatures. While you can certainly argue it's accuracy, especially
- 35:50Speaker 1: for older data, it's still just data. It's not science.
- 35:53Speaker 1: The part that gets me upset about the term settled sciences.
- 35:56Speaker 1: By definition, science is never settled, and that's an all caps.
- 36:01Speaker 1: I think we talked a lot about this is the
- 36:03Speaker 1: scientific method of this stuff. You guys actually did a
- 36:05Speaker 1: podcast on the scientific method, so you should know that
- 36:08Speaker 1: at best you can show a particular theory is supported
- 36:11Speaker 1: by existing data and not contradicted by anything we know
- 36:14Speaker 1: of at the time. But there's a reason that ultra
- 36:17Speaker 1: successful theories like Newton's theory of gravity hind science. Theory
- 36:20Speaker 1: of relativity are still theories. They could be completely discredited
- 36:24Speaker 1: by a single piece of data contradicting them. So the
- 36:27Speaker 1: whole idea of taking a body of fact saying it's
- 36:29Speaker 1: settled is far more political concept than scientific one. While
- 36:32Speaker 1: people with various viewpoints in the subject would like to
- 36:35Speaker 1: have someplace to plant their ideological flag, saying something is
- 36:40Speaker 1: indisputedly true as opposed to probably false is simply not
- 36:43Speaker 1: something science and the scientific method is equipped to do.
- 36:47Speaker 1: In short, science has never settled. You cannot simply say
- 36:50Speaker 1: this is true, move on. That's not how it works.
- 36:53Speaker 1: And that is from Spencer Carpenter right here in our
- 36:56Speaker 1: own Smyrna, Georgia. We're not in St. Well, I mean
- 37:00Speaker 1: it's it's nearby. What I just did is what Spencer
- 37:05Speaker 1: just did. Spencer, I was using a literary device. I
- 37:08Speaker 1: was actually using the same type of argument that science
- 37:12Speaker 1: that non science climate deniers use against scientists. I was
- 37:17Speaker 1: basically saying, like, it's done, drop it. There's enough science
- 37:21Speaker 1: there to say you're you're you're wrong. Let's move on
- 37:26Speaker 1: and just all accept that climate science is going it's
- 37:28Speaker 1: a layoff. So that was a clever ruse. It wasn't
- 37:31Speaker 1: a ruse at all. It was it was just I
- 37:34Speaker 1: was not being literal like apparently, which is what Spencer
- 37:38Speaker 1: deals in literal terms. Uh, if you want to take
- 37:42Speaker 1: us to test because you are overly literal, we want
- 37:45Speaker 1: to hear from you. You can tweet to us at
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