1064-Microtubule Dynamics & Cardiomyocyte Growth Direction
This research explores how microtubule dynamics serve as a molecular switch to determine the direction of heart muscle cell growth, known as cardiac hypertrophy. By utilizing animal models, human tissue samples, and advanced imaging, the authors demonstrate that stabilizing microtubules triggers cell widening and heart wall thickening through the relocalization of protein synthesis and the compaction of cell-to-cell contacts. In contrast, destabilizing microtubules promotes cell lengthening and heart chamber dilation by weakening these structural connections at the intercalated disc. These…
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