1475-Restoring Macrophage Clearance to Limit Aging
This research identifies tissue-resident macrophages (TRMs) as essential regulators of systemic aging through their role in clearing senescent neutrophils. As organisms age, TRMs increasingly express the EP2 receptor, which triggers signaling pathways that disrupt mitochondrial health and impair the efferocytosis, or cellular disposal, of these short-lived immune cells. Consequently, uncleared neutrophils accumulate across major organs, undergoing degranulation and NETosis that cause chronic inflammation and tissue damage. Experimental evidence from mice shows that genetically deleting or…
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