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Recapping the A4M Longevity Fest in Las Vegas · The Science of Skin

• 0:08
  SPEAKER_00: Hi, I'm Dr.
• 0:08
  SPEAKER_00: Patty Ferris.
• 0:09
  SPEAKER_00: I'm a board certified dermatologist and co-host of the Science of Skin podcast.
• 0:15
  SPEAKER_00: And I'm joined by my co-host today.
• 0:17
  SPEAKER_00: What a treat, Ted.
• 0:18
  SPEAKER_00: We don't usually get to record together.
• 0:20
  SPEAKER_01: So fun.
• 0:20
  SPEAKER_01: But then again, we don't usually get to go to meetings together and actually not have to present or do something like that.
• 0:27
  SPEAKER_01: And we could just attend.
• 0:28
  SPEAKER_01: And we just did that, which was fun.
• 0:30
  SPEAKER_00: It's an incredible experience not to be on the podium.
• 0:33
  SPEAKER_00: You know why?
• 0:34
  SPEAKER_00: Because you learn a lot.
• 0:36
  SPEAKER_01: You really do.
• 0:37
  SPEAKER_01: Yeah.
• 0:37
  SPEAKER_01: We just came back from the A4M longevity fest in Las Vegas.
• 0:42
  SPEAKER_01: And we thought we would sit down and record a podcast because it was so mind-blowing what we learned, or maybe didn't learn, that uh we we wanted to share.
• 0:53
  SPEAKER_00: So just for our listeners who are not familiar with A4M, it's the American Academy of Anti-Aging Medicine group, and they host several meetings a year.
• 1:03
  SPEAKER_00: And I think the first thing we can say, Ted, is the interest in anti-aging medicine and longevity is huge.
• 1:10
  SPEAKER_00: I mean, there were how many practitioners there?
• 1:12
  SPEAKER_00: Thousands.
• 1:13
  SPEAKER_01: Thousands, thousands.
• 1:14
  SPEAKER_01: I mean, we got there on the first day when it started.
• 1:17
  SPEAKER_01: We thought we were being good boys and girls.
• 1:19
  SPEAKER_01: And we there were people there that had probably lined up for a few hours and got seats at the very, very front.
• 1:25
  SPEAKER_01: I've never seen a bigger um auditorium space.
• 1:28
  SPEAKER_01: And we were in the way, way back.
• 1:30
  SPEAKER_01: And they were talking, Patty, about the value of longevity medicine, just the industry.
• 1:34
  SPEAKER_01: And they were saying$1.4 trillion in either five or 10 years.
• 1:39
  SPEAKER_01: We were so far back I couldn't hear them that well.
• 1:41
  SPEAKER_00: We couldn't hear or see the slides.
• 1:44
  SPEAKER_00: Good news, we had an app.
• 1:47
  SPEAKER_00: They were prepared.
• 1:48
  SPEAKER_00: You're right.
• 1:48
  SPEAKER_00: It's an incredible industry, and there's so many different fractions involved in it, and so many different practitioners.
• 1:55
  SPEAKER_00: So we met physicians, lots of really knowledgeable physicians, and made some new friends, which was cool.
• 2:01
  SPEAKER_00: But we also, there's chiropractors there, there's uh uh nurse practitioners, PAs, there's uh Natropaths.
• 2:09
  SPEAKER_00: Naturopaths, that's what I was listening, trying to grab for.
• 2:11
  SPEAKER_00: Yeah, the NDs, lots of them also on the podium.
• 2:15
  SPEAKER_00: And it was just an incredible group of practitioners, all kind of chomping at the bit to learn what's the latest in longevity.
• 2:24
  SPEAKER_01: I decided to go in a day early, Patty, and I went to the full-day hormone session, and I had no idea what I was walking into, but it was essentially a primer on the estrogen pathway in the female body and the male body, going down to every metabolite.
• 2:41
  SPEAKER_01: I I was just starstruck by these speakers who knew it like the back of their hand.
• 2:46
  SPEAKER_01: Right.
• 2:47
  SPEAKER_01: And these were not MDs, these were, I think one of them was a naturopath, another one was um a nurse practitioner, but they had obviously studied so hard and and learned every single pathway.
• 2:59
  SPEAKER_01: I literally was just like, I feel like I'm in med school again.
• 3:02
  SPEAKER_01: And I'm not even sure I learned all that in med school, quite frankly.
• 3:05
  SPEAKER_00: We probably didn't, but you know, there was a lot of discussion on female health and female longevity.
• 3:12
  SPEAKER_00: That was a big theme.
• 3:14
  SPEAKER_00: There was one of the first sessions we attended on Friday was a female longevity blueprint, and it was titled Balancing Hormones, Mitochondria and Metabolism.
• 3:24
  SPEAKER_00: I thought it was a really good talk.
• 3:26
  SPEAKER_00: It started with some sort of staggering statistics on female health, like one in three women dies of a myocardial infarction or a stroke, and one woman every 3.5 seconds dies from cardiovascular disease.
• 3:38
  SPEAKER_00: And then they talked about just the decline in ovarian function and how that is related to systemic aging.
• 3:46
  SPEAKER_00: So, again, the stuff that you learned in your session playing out in this whole female longevity play, it was so interesting.
• 3:55
  SPEAKER_00: They talked about perimenopause being the most symptomatic time of life in women.
• 3:58
  SPEAKER_00: And I think every one of us who's been through it or is currently going through it will corroborate that.
• 4:03
  SPEAKER_00: And just that, you know, it causes the loss of hormones, causes acceleration of cardiovascular degeneration, bone degeneration, cognitive decline, and of course, metabolic aging.
• 4:15
  SPEAKER_00: Uh, they also talked some interesting things about cortisol and how it affects the female brain.
• 4:20
  SPEAKER_00: And we all know that women have a tremendous amount of stress because it's that work-life balance and dealing with the kids and all the activities and your career.
• 4:28
  SPEAKER_00: And they talked about that it was associated with smaller brain volume, lower glucose metabolism, and higher beta, higher beta amyloid, that it's high cortisol in the female brain.
• 4:40
  SPEAKER_00: Super interesting to me.
• 4:43
  SPEAKER_00: She made a point, and this talk was given by Sarah Saul, who is an MD.
• 4:47
  SPEAKER_00: She's written a bunch of books, bestsellers, uh, talked about HRT and that it really should be started within the first to seven years to prevent a lot of what's happening here.
• 4:58
  SPEAKER_00: Um, she gave an assessment of a blueprint for women, how you might evaluate the patients.
• 5:02
  SPEAKER_00: It was complicated, so I won't go into details, but I thought this was a really good talk, and it sort of set the tone that there was a lot of female-centric content in this in this meeting.
• 5:14
  SPEAKER_01: Yeah, and in my session, uh, the hormone session, we did have content on men and testosterone in general.
• 5:20
  SPEAKER_01: And there was a lot of time spent discounting the myths regarding the harmful effects of testosterone.
• 5:26
  SPEAKER_01: There's been a lot of talk about whether there's cardiovascular risks, for example, uh, and and also just because of the aromatase enzyme conversion of testosterone to estrogen and leading to a higher estrogenic state for men, which can be harmful as well.
• 5:41
  SPEAKER_01: And and so there was a lot of time spent on that, and I think they discounted that using um the latest data pretty well.
• 5:47
  SPEAKER_01: I'd like to do my own research, of course, but um for now it seems like you know, all these gym bros who are on testosterone, as they kept saying, not my words theirs, uh I love that.
• 5:59
  SPEAKER_01: They said they actually may have it right.
• 6:01
  SPEAKER_01: Uh, and and you know, we just have to really consider the levels of testosterone that our patients are on and and what we consider normal versus not normal.
• 6:10
  SPEAKER_01: There was, uh I think that kind of pervaded the entire conference, so Patty, this this idea of normal lab values that we get from labs and how those actually may not be truly normal for our patients, and we have to take everything with a grain of salt.
• 6:23
  SPEAKER_00: Yeah, well, it's always a snapshot in time, was was also sort of what I took home on that.
• 6:29
  SPEAKER_00: Um, there was a lot of talk about exercise and muscle mass.
• 6:33
  SPEAKER_00: It was a kind of a cool talk called uh muscle is medicine, which I thought was really kitschy in the history of the science and the future of strength.
• 6:42
  SPEAKER_00: And this was, I thought, an interesting talk because as we know with the GLP1s now, we have people losing a lot of weight, but they're losing muscle mass too, especially the older patients, apparently, and the postmenopausal female are more at risk for that loss of muscle mass.
• 6:58
  SPEAKER_00: She talked about the things you would expect, like resistance training and increasing your protein.
• 7:04
  SPEAKER_00: I don't know how they expect us to eat all this protein, but you need a lot of protein, wasn't it like 30 grams a meal three times a day?
• 7:13
  SPEAKER_01: Honestly, that was one of the most interesting parts.
• 7:15
  SPEAKER_01: I mean, we all not might maybe not all of us, but a lot of us listen to these longevity podcasts to read the books, and I'm just very interested in it overall.
• 7:22
  SPEAKER_01: I just find it fascinating.
• 7:23
  SPEAKER_01: Not because I want to live forever, just because I think it's preventative medicine as well.
• 7:27
  SPEAKER_01: And um, they were talking about how important it was to eat a lot of your protein early in the day for muscle building, like 30 grams of protein for women at breakfast.
• 7:39
  SPEAKER_01: And you and I were joking, that's steak and eggs.
• 7:41
  SPEAKER_01: I mean, I don't know you know if you want to get if you want to get you know all the amino acids in a bio, in a biologically available form, it's animal protein.
• 7:50
  SPEAKER_01: And so that's kind of steak and eggs.
• 7:52
  SPEAKER_01: And wow, that's a lot.
• 7:54
  SPEAKER_00: Yeah, it was a lot.
• 7:55
  SPEAKER_00: So I I thought it was a very interesting talk, really highlighting how important maintaining your muscle mass is as you get older for longevity, but also for your health span.
• 8:07
  SPEAKER_00: You know, we know how so many older patients literally, you know, break a hip and die.
• 8:12
  SPEAKER_00: And having muscle mass is the key to being able to survive things like that.
• 8:16
  SPEAKER_00: So super interesting talk, I thought.
• 8:19
  SPEAKER_00: Um, another take-home that I got, which I thought was very cool, and it kind of plays on what you're saying about longevity in general, is that medicine 3.0, so we're we're done with 2.0.
• 8:31
  SPEAKER_00: Apparently, we're on to 3.0 now, is it has four P's in it, and it's predictive, preventative, personalized, and participatory.
• 8:41
  SPEAKER_00: And I love that.
• 8:42
  SPEAKER_00: And that came again from Sarah Zall's talk on female longevity blueprint, but it it we have to start participating, and that's where all this exercise comes in, and you know, weight training and you know, 30 minutes a day of uh additional exercise or aerobic exercise and weight training, you have to participate.
• 9:02
  SPEAKER_00: Like we can't make people live longer and have a really good health span unless they're willing to participate.
• 9:09
  SPEAKER_01: Yeah, again, and I think this all ties in with the hormones also, especially for women.
• 9:13
  SPEAKER_01: Now that we've they've removed the box warning for hormone replacement treatment, uh, that getting back on the estrogen and progesterone uh therapy is so important for women peri and post-menopausal, and it also helps to build muscle and maintain what you have.
• 9:27
  SPEAKER_01: Um, it it was interesting in terms of the the participatory exercise because they kept talking about the zone two, 150 minutes per week of zone two heart rate, which is you know a brisk walk, right?
• 9:39
  SPEAKER_01: I think most people can do that, but but then they did bring in, you know, at least once doing HIIT training, uh high intensity interval training, once per week, really focusing on that, if not twice, and then adding in resistance training as well.
• 9:53
  SPEAKER_01: And goodness, when you add all that up, it's it's a lot of time.
• 9:56
  SPEAKER_00: It is a lot of time.
• 9:57
  SPEAKER_01: Just to get all that in.
• 9:59
  SPEAKER_00: I think the hardest thing is when you're working is to find the time to exercise.
• 10:02
  SPEAKER_00: I was always like in the gym at 5 30 in the morning and I was going into the office regularly.
• 10:08
  SPEAKER_00: You know, you don't have any other time to do it when you have kids coming home.
• 10:12
  SPEAKER_00: So that that you know, that is that's an issue in terms of the participatory part.
• 10:18
  SPEAKER_01: Yeah.
• 10:19
  SPEAKER_00: Um, what about that interesting lecture that we heard with the HIV patients?
• 10:24
  SPEAKER_00: You can recapitulate that probably better than I can.
• 10:26
  SPEAKER_01: So interesting.
• 10:28
  SPEAKER_01: I mean, there was a couple of different aspects of this lecture.
• 10:31
  SPEAKER_01: And what they were talking about is using epigenetic methylation patterns to predict response to GLP1 agonists.
• 10:40
  SPEAKER_01: And the the this was born from a paper on uh HIV patients who are on retroviral therapy often have lipogenesis.
• 10:50
  SPEAKER_01: There's lipogenic effects, and so they they build fat that they try and and lose.
• 10:54
  SPEAKER_01: Uh, and then there was another paper done by Lily on non-alcoholic uh fatty liver disease.
• 11:01
  SPEAKER_01: It's it's called something else, and I can never remember now.
• 11:03
  SPEAKER_01: But um they, especially with the the Lily patients, they were able to get uh either the data or actually some tissue and figure out the epigenetic pattern and then look at who did well on the terzeptide based on the methylation pattern.
• 11:20
  SPEAKER_01: It's just a personalization.
• 11:22
  SPEAKER_01: We talk about medicine 3.0, it's it was using you know, uh essentially mathematical um assessment of the data.
• 11:29
  SPEAKER_01: I don't know if it was a large learning models or or how he did it, but he was really interesting.
• 11:35
  SPEAKER_01: And that was the best lecture I think we heard all the entire session was really the scientists going through and saying, you know, we can really use the epigenome more than just to assess biologic aging, because we know through methylation and chromatin and histone modifications, you can use the epigenome to make a clock of biologic aging, but also to assess epigenetic effects of medications.
• 11:59
  SPEAKER_01: And I thought that was brilliant.
• 12:01
  SPEAKER_01: And and I could see that becoming more and more mainstream over the next five to ten years.
• 12:06
  SPEAKER_00: Super high tech and very interesting.
• 12:10
  SPEAKER_00: Uh, tons about the microbiome.
• 12:12
  SPEAKER_00: Microbiome is you know totally tied to aging, and they called it, you know, that whole microbiome aging connection, just like we have the gut brain and the gut skin.
• 12:25
  SPEAKER_00: And I heard several lectures on the microbiome, one from uh a woman physician who was using familial fecal transplants to treat various conditions.
• 12:40
  SPEAKER_00: I thought it was super interesting.
• 12:42
  SPEAKER_00: They were looking at sequencing in kids who have um all kinds of medical problems like long COVID or um autism, right?
• 12:53
  SPEAKER_00: Autism, exactly, bipolar disorder, all kinds of different things, not just children, but adults as well.
• 12:59
  SPEAKER_00: But she had actually treated some kids with autism with familial fecal transplants.
• 13:05
  SPEAKER_00: So connecting all of these dots again, you know, to how we age, health span, lifespan, and in her case, treating lots of interesting conditions or at least looking at those conditions.
• 13:18
  SPEAKER_00: I also heard a lecture on the microbiome and polycystic ovarian disease or syndrome PCOS and how you have to really look at the gut microbiome in those patients because the gut microbiome influences our ability to our insulin sensitivity, basically, and how we regulate glucose metabolism.
• 13:36
  SPEAKER_00: And we know that's a huge problem in that patient population.
• 13:39
  SPEAKER_00: So that was again a super interesting talk.
• 13:42
  SPEAKER_01: Assessing the gut microbiome, though, first of all, is not fun.
• 13:46
  SPEAKER_01: And and second of all poop.
• 13:50
  SPEAKER_00: Yeah.
• 13:52
  SPEAKER_00: Lots of poop, lots of poop exhibits at this meeting, right?
• 13:55
  SPEAKER_01: There was there are lots of little poop emoji things all over.
• 13:59
  SPEAKER_01: Um but uh the other thing is you you wonder how sensitive it is.
• 14:03
  SPEAKER_01: That was the the big takeaway I had was you know, is it is it a a snapshot in time with the microbiome, the gut microbiome?
• 14:09
  SPEAKER_01: Do you need to do it serially?
• 14:11
  SPEAKER_01: They talked about that, you know, we know butyrate as a short chain fatty acid is anti-inflammatory.
• 14:16
  SPEAKER_01: You want to increase butyrate.
• 14:17
  SPEAKER_01: And then there was another bacteria that they wanted to increase.
• 14:20
  SPEAKER_01: Um, it starts with an A.
• 14:22
  SPEAKER_01: I don't remember, Patty, do you remember what it is?
• 14:24
  SPEAKER_00: I could I couldn't I can't couldn't pronounce it.
• 14:26
  SPEAKER_01: Oh my goodness, I couldn't either.
• 14:27
  SPEAKER_01: They were saying it like it was nothing, and I was having to like felt like it was Greek.
• 14:32
  SPEAKER_01: But um, yeah, there's this one bacteria that we need to increase the um uh uh load of in our gut in order to to be healthy as well.
• 14:40
  SPEAKER_01: So um much more for us to learn on the gut microbiome just as medical doctors and how we take advantage of it.
• 14:47
  SPEAKER_01: But you know, I give a lecture on rosacea in the gut, and I and I through my research on that lecture, it really came to the came to the conclusion that this this idea of fecal transplant may be so important, not only for rosacea, but lots of inflammatory disease in the skin, because it could all be related to the gut.
• 15:03
  SPEAKER_01: And I'm sure my our integrative derm colleagues are like rolling their eyes right now, like we've been saying this for 20 years, Ted.
• 15:09
  SPEAKER_01: Where have you been?
• 15:10
  SPEAKER_01: But you know, it's sometimes it takes me a while, but uh I'll get there.
• 15:13
  SPEAKER_00: Takes us a while, exactly.
• 15:15
  SPEAKER_00: SIBO, I know, has been shown in rosacea.
• 15:18
  SPEAKER_00: Yeah, so it it is super interesting.
• 15:21
  SPEAKER_00: Um other things that we heard a lot about were peptides.
• 15:25
  SPEAKER_00: Oh boy.
• 15:26
  SPEAKER_00: Oh boy, did we hear a lot about peptides?
• 15:28
  SPEAKER_00: And we had saw an exhibit hall full of peptides, every peptide imaginable.
• 15:33
  SPEAKER_00: So I heard one lecture where um it was a PhD speaking then.
• 15:38
  SPEAKER_00: He was talking about liposomally encapsulating peptides and how that could really be a game changer in terms of it's hard to deliver these things through the GI track because of their size, because they tend to get broken down very quickly, they're not very stable.
• 15:54
  SPEAKER_00: But, you know, he kind of talked about the pros and cons, like you know, of IV and being able to take them orally at home, which obviously has certain benefits just in terms of you know, cost and time and all of those things.
• 16:08
  SPEAKER_00: But uh it was an interesting lecture.
• 16:10
  SPEAKER_00: Uh, they talk about a lot of the peptides we talk about in dermatology, copper GHK, the first peptide ever put into a into a cream.
• 16:18
  SPEAKER_00: In every booth we went to, it was like, you know, talking about that particular peptide for skin and hair and all the things that we do topically with it.
• 16:28
  SPEAKER_00: So I thought it was that was really interesting.
• 16:30
  SPEAKER_00: Some of the others, the BP 157, we saw a lot of that, which is one that modulates growth hormones, growth factors, um, is a repairing, it's kind of like a promotes angiogenesis.
• 16:44
  SPEAKER_00: So there was a lot of talk about peptides.
• 16:47
  SPEAKER_00: You know, they're alive and well in this whole longevity space.
• 16:50
  SPEAKER_00: I think maybe we got to wait for the science to catch up, Ted, because we kept kind of waiting for the the big aha moment.
• 16:57
  SPEAKER_00: And I don't think we got the aha moment, but but still there's a lot of enthusiasm, and there are lots of people using these in their patients and recommending them.
• 17:05
  SPEAKER_00: And you know, you look at social media, they're stacking these.
• 17:08
  SPEAKER_00: I'm taking this one, I'm taking that one.
• 17:10
  SPEAKER_00: I can't even remember the the names of them.
• 17:13
  SPEAKER_00: You and I keep going, what's that BP BP?
• 17:17
  SPEAKER_01: I know the needs of a better PR agent because these names are ridiculous.
• 17:20
  SPEAKER_01: They do.
• 17:21
  SPEAKER_01: Yeah, I think um I we we're so it's so difficult with the peptides because you want more data, but they're essentially generics, right?
• 17:31
  SPEAKER_01: So you're not gonna, it's not like one company can make them and just have ownership of that one peptide.
• 17:35
  SPEAKER_01: So it's everybody's making them.
• 17:37
  SPEAKER_01: Everybody's making them.
• 17:38
  SPEAKER_01: So it's really co difficult to get, you know, really large randomized trials that we would need to feel super comfortable with them.
• 17:44
  SPEAKER_01: And because everybody's making them, that also raises the question of formulation and production.
• 17:50
  SPEAKER_01: And are they contaminated?
• 17:52
  SPEAKER_01: And oh gosh, I mean, there's so much, you know, on Podium, they were touting the benefits, and it this patient did this and that patient did that.
• 17:59
  SPEAKER_01: I use it all the time.
• 18:00
  SPEAKER_01: And these are these crazy busy longevity docs who you know see tons of patients and are using them.
• 18:05
  SPEAKER_01: And I'm not saying they're being unsafe.
• 18:07
  SPEAKER_01: I just think for myself, I I just would love to see more data, but I'm not sure we're ever going to get more data.
• 18:13
  SPEAKER_01: So that's the whole crux of longevity, unfortunately.
• 18:16
  SPEAKER_00: Yeah.
• 18:17
  SPEAKER_00: And you know, I thought about it because it's very hard to find endpoints.
• 18:22
  SPEAKER_00: I mean, the the, you know, you and I were hanging a lot on biomarkers, you know, we were, I mean, because it's very hard to measure these things.
• 18:31
  SPEAKER_00: You know, how does it really impact the patient's longevity and long their health span?
• 18:35
  SPEAKER_00: How do you quantify that?
• 18:37
  SPEAKER_00: You know, there's not, it's just not easy.
• 18:39
  SPEAKER_00: Nutritional studies are difficult too in the same regard.
• 18:42
  SPEAKER_00: You make these interventions and it can be years before anybody sees a difference.
• 18:47
  SPEAKER_00: And they talked a ton about nutrition, nutritional supplements, nutrition, polyphenols.
• 18:52
  SPEAKER_00: We heard a whole lecture on polyphenols, which was cool because I love polyphenols as a topical.
• 18:57
  SPEAKER_01: Oh, absolutely.
• 18:58
  SPEAKER_00: And we know that they're really important uh phytonutrients, great antioxidants, they upregulate your own intrinsic antioxidants.
• 19:06
  SPEAKER_00: So they're, you know, they're amazing molecules, but we've heard a whole lecture on those.
• 19:12
  SPEAKER_00: Uh lots of good advice, I thought, on nutrition, besides protein.
• 19:16
  SPEAKER_00: You know, following the Mediterranean diet came up quite a few times.
• 19:20
  SPEAKER_01: Yeah.
• 19:20
  SPEAKER_00: Uh, what you put in your mouth makes a difference in how you fare long term for sure.
• 19:25
  SPEAKER_01: Yeah.
• 19:26
  SPEAKER_01: It was speaking of nutrition, I think what surprised me, I thought we were going to get a lot more of go vegan, go veggie, no, uh, that kind of talk.
• 19:34
  SPEAKER_01: And there was none of the carnivore.
• 19:36
  SPEAKER_00: It was a carnivore.
• 19:38
  SPEAKER_01: Exactly.
• 19:39
  SPEAKER_01: Animal protein, animal protein, as long as it's the right animal protein, you know, not hormonal, um, no hormones, grass-fed, free range.
• 19:46
  SPEAKER_01: Like they really focused on the quality of the protein.
• 19:49
  SPEAKER_01: And then, of course, with the Mediterranean diet, you don't eat, you know, meat that often.
• 19:54
  SPEAKER_01: Um, they certainly, it was more fish, right?
• 19:58
  SPEAKER_01: But they certainly talked about the benefit of animal protein, lean animal protein as a source of you know, biologically available amino acids and how important that is.
• 20:07
  SPEAKER_01: It really made me I was surprised.
• 20:09
  SPEAKER_01: Uh, you know, I've been pescatarian now for six years, and and um maybe you know, it the right way to go, especially for women.
• 20:17
  SPEAKER_01: Um I thought it may be the right thing is to to consider eating that high grade, high protein every once in a while.
• 20:24
  SPEAKER_01: Um, they certainly were saying that it's worth it.
• 20:27
  SPEAKER_00: So yeah, absolutely.
• 20:30
  SPEAKER_00: Uh let's take our listeners for a tour through the exhibit hall.
• 20:35
  SPEAKER_00: I mean, you could get everything and anything you've ever imagined.
• 20:40
  SPEAKER_00: How about red light?
• 20:41
  SPEAKER_00: Red light blankets, red light tanks, red light masks.
• 20:51
  SPEAKER_01: We'd look pretty cool.
• 20:53
  SPEAKER_01: Um, there there was, I mean, please don't light a match in a longevity exhibit hall because there's so much hyperbaric oxygen going on that you know it would be disastrous.
• 21:03
  SPEAKER_01: Um for sure, yes.
• 21:06
  SPEAKER_00: Uh lots of interest in hyperbarics, which honestly is something that we all use in medicine, and it does have incredible benefits in so many of our medical specialties.
• 21:18
  SPEAKER_00: But yeah, that was there.
• 21:19
  SPEAKER_00: And then the supplement companies, lots of supplement companies, probably more than anything.
• 21:24
  SPEAKER_00: We saw supplements.
• 21:26
  SPEAKER_00: Not as much skincare as I expected, truthfully, but a lot of supplements.
• 21:30
  SPEAKER_01: There were some interesting skincare companies there, though.
• 21:33
  SPEAKER_01: We met, and we people might see those at our conference because we were pretty interested in what they were doing.
• 21:39
  SPEAKER_01: They had some really novel ideas and novel ingredients too.
• 21:43
  SPEAKER_01: Um you know, we had so many supplement samples that I had a little tummy ache at the end of the day.
• 21:49
  SPEAKER_01: Don't there's a lesson there.
• 21:50
  SPEAKER_01: You can only have so much magnesium, what is it, citrate?
• 21:53
  SPEAKER_01: Citrate.
• 21:55
  SPEAKER_00: I'm not sure which one they gave us.
• 21:57
  SPEAKER_00: I can I was hoping it was the one that didn't regulate your body.
• 22:00
  SPEAKER_00: For your sake, because I didn't take that.
• 22:02
  SPEAKER_01: Yeah, just let me tell you anyway, be careful with the magnesium.
• 22:06
  SPEAKER_00: And then um what you taste in the eats in it all.
• 22:10
  SPEAKER_01: Exactly.
• 22:10
  SPEAKER_01: Lots of electrolyte drinks.
• 22:11
  SPEAKER_01: Man, I was do not check my potassium either right now.
• 22:14
  SPEAKER_01: I was trying to yeah.
• 22:16
  SPEAKER_00: I mean, there was really interesting.
• 22:19
  SPEAKER_00: And we learned, I think, a lot from talking to some of the manufacturers of the supplements.
• 22:23
  SPEAKER_00: We learned about the NSF certification.
• 22:26
  SPEAKER_00: And uh, you know, that's one thing that if if people are looking at supplements and they want to know what to look for, that attest to that they're manufactured properly, that they have actually the ingredients that they're supposed to have on the label are in the supplement.
• 22:41
  SPEAKER_00: And um, the safety, because they do toxicology, make sure it's not heavy metal contamination.
• 22:46
  SPEAKER_00: So there was a lot of NSF certified companies there, which was good to see.
• 22:51
  SPEAKER_01: What else do we see in that exhibit hall?
• 22:54
  SPEAKER_01: I mean, there was, you know, there were booths that said we cure cancer, which of course we didn't really hit up that much.
• 23:01
  SPEAKER_00: Um, but we saw a new cancer screening tool that was interesting, similar to the gallery test, the cell-free DNA test.
• 23:07
  SPEAKER_01: Yeah.
• 23:08
  SPEAKER_00: And then met a dermatopathologist interested and was involved with that company.
• 23:12
  SPEAKER_00: Super interesting.
• 23:13
  SPEAKER_00: I mean, early detection with liquid biopsies are definitely mainstream and coming into medicine.
• 23:22
  SPEAKER_01: Um, we saw exosomes.
• 23:24
  SPEAKER_01: There were quite a few exosome companies there.
• 23:27
  SPEAKER_01: We learned some um of the kind of back end aspects of the exosome business that a lot of these companies are actually purchasing exosomes from the same manufacturer or supplier and and touting them as very special, but indeed they're not they're not even their exosomes.
• 23:43
  SPEAKER_01: So that was eyebrow raising for us, but otherwise they were they were touting their exosomes from all sorts of different um sources and mostly misanchimal.
• 23:53
  SPEAKER_01: I thought mostly Ms.
• 23:54
  SPEAKER_00: Anchimal's themselves.
• 23:55
  SPEAKER_01: Morton's jelly, yeah.
• 23:56
  SPEAKER_00: Yeah, Morton's jelly.
• 23:58
  SPEAKER_01: Um, what else?
• 24:00
  SPEAKER_01: Lots of device companies there.
• 24:01
  SPEAKER_01: We saw some interesting handheld devices.
• 24:03
  SPEAKER_01: Seems like plasma is is making a comeback.
• 24:06
  SPEAKER_00: Yeah, plasma.
• 24:07
  SPEAKER_00: That was so interesting.
• 24:09
  SPEAKER_01: Yep, handheld plasma devices with either with little cartridges, which democratizes us, you know, the the availability of of you know topical of handheld laser devices for sure.
• 24:21
  SPEAKER_01: Um I think that was very cool.
• 24:24
  SPEAKER_01: Yeah, uh nitric oxide we had nitric oxide.
• 24:28
  SPEAKER_00: Went to the nitric oxide company and yeah, chatted with them and uh super interesting.
• 24:34
  SPEAKER_01: A professor from from Baylor College of Medicine had done all this research and started a company on nitric oxide and in both in tablet form and topically.
• 24:44
  SPEAKER_01: That was very interesting too.
• 24:46
  SPEAKER_01: I think that kind of wraps up what we saw in the exhibitor hall.
• 24:51
  SPEAKER_01: There were major themes, there were lots of book signings.
• 24:55
  SPEAKER_00: Yeah, these are pro prolific writers.
• 24:57
  SPEAKER_00: There was a book signing every 15 minutes somewhere, and they were giving away the books, and they had lines waiting for them, that's for sure.
• 25:05
  SPEAKER_00: And we got a book.
• 25:06
  SPEAKER_01: You did.
• 25:07
  SPEAKER_00: We got a book.
• 25:08
  SPEAKER_01: I gave it to my wife, the 50 Things You Should Know About Menopause.
• 25:11
  SPEAKER_00: You better read it first.
• 25:15
  SPEAKER_00: No, Ted, this could be it for you.
• 25:17
  SPEAKER_00: You have write a book, Living with Menopause.
• 25:20
  SPEAKER_01: Yeah, that's right.
• 25:21
  SPEAKER_00: Living with menopause.
• 25:22
  SPEAKER_00: That could be a New York Times bestseller.
• 25:25
  SPEAKER_01: Yeah.
• 25:26
  SPEAKER_00: That's a tough time for men.
• 25:28
  SPEAKER_01: Yeah, but not for me, because my wife is perfect in every way, Patty.
• 25:32
  SPEAKER_01: So when she listens to the episode, you're so buried above your pay grade.
• 25:36
  SPEAKER_00: I don't know how you did that.
• 25:40
  SPEAKER_00: Oh, Hila, we love you.
• 25:42
  SPEAKER_00: We love totally love you.
• 25:44
  SPEAKER_00: Anyway, it was a great experience.
• 25:46
  SPEAKER_00: I think, you know, just for you and I, it was eye-opening.
• 25:50
  SPEAKER_00: It was a learning experience.
• 25:53
  SPEAKER_00: I hope that we can practice medicine 3.0 because I love that.
• 25:57
  SPEAKER_00: I think that was one of the coolest things.
• 26:00
  SPEAKER_00: Let's let's prevent, let's participate, and you know, rock on into the longevity world.
• 26:07
  SPEAKER_00: Basically, we have a longevity session, two of them coming up in the Sheer Sciences Kin Summit, which we hope everyone will attend.
• 26:15
  SPEAKER_01: We're really expanding our longevity content.
• 26:18
  SPEAKER_01: We're taking speakers outside of dermatology and and adding them to our summit to really elevate the science and get people up to speed as to what's going on, because we know that you can't go to these longevity um meetings outside of our specialty.
• 26:32
  SPEAKER_01: It's it's difficult to get there.
• 26:34
  SPEAKER_01: And so we're trying to bring it to you in the summit curated, of course.
• 26:38
  SPEAKER_01: And we're just going to continue to do that because I think Patty and I have a strong conviction that that longevity is not going anywhere.
• 26:44
  SPEAKER_01: It's becoming more mainstream.
• 26:46
  SPEAKER_01: And we're going to do our best to highlight the data behind longevity so that our peers can incorporate that into their medical practices or their aesthetic practices and feel comfortable doing it just right alongside the novel therapeutics that we have for inflammatory disease.
• 27:04
  SPEAKER_01: So stay tuned for that.
• 27:06
  SPEAKER_01: Remember that the summit is September 17th through the 20th.
• 27:09
  SPEAKER_01: We we increase the number of days.
• 27:10
  SPEAKER_01: We're starting on Thursday afternoon this in 2026.
• 27:14
  SPEAKER_01: Of course, it's going to be in Austin at the beautiful Fairmont Hotel.
• 27:17
  SPEAKER_01: Uh, thank you so much for listening.
• 27:19
  SPEAKER_01: My name is Ted Lane.
• 27:20
  SPEAKER_01: I'm with Dr.
• 27:21
  SPEAKER_01: Patty Ferris, who's my partner in crime with both the Science of Skin Summit and podcast and webinars.
• 27:27
  SPEAKER_01: We appreciate you listening.
• 27:28
  SPEAKER_01: Of course, um, most of the the growth that we've had in the podcast is through word of mouth.
• 27:32
  SPEAKER_01: So if you've enjoyed this, if you've learned something, please tell your peers and everybody in your office.
• 27:37
  SPEAKER_01: We we love to have people tell us that they they listen to our podcast.
• 27:41
  SPEAKER_01: That happened to me today.
• 27:42
  SPEAKER_01: And uh it just it just really gives us um some more support and makes us want to do this even more.
• 27:48
  SPEAKER_01: So thank you for that.
• 27:49
  SPEAKER_01: Uh, this will be our last conversation for 2025.
• 27:53
  SPEAKER_01: So for everybody listening, we wish you very happy holidays and a joyful and certainly healthy 2026.
• 27:59
  SPEAKER_01: And we look forward to um speaking to you again next year.
• 28:03
  SPEAKER_00: Thanks everyone for listening.
• 28:04
  SPEAKER_00: Have a great holiday.