Latest / Ageless and Timeless Podcast® / Dr nathan bryan

Transcript

Dr nathan bryan · Ageless and Timeless Podcast®

0:08
Speaker 1: Good morning everyone.
0:09
Speaker 2: This is Michelle Hughes from Ageless and Timeless. I have
0:13
Speaker 2: a guest today that I've been talking to for over
0:15
Speaker 2: a year now, and I have to tell you a
0:18
Speaker 2: little backstory about doctor Nathan Bryan because he's such a
0:23
Speaker 2: special man and this will indicate what I'm more validate
0:29
Speaker 2: what I'm talking about.
0:30
Speaker 1: So I was at the Radfest festival.
0:32
Speaker 2: And Anaheim about a year or so ago, and I
0:37
Speaker 2: walked over to the booth called N one oh one
0:40
Speaker 2: and Nitric outside. If anyone has heard of the Nightrik Outside,
0:45
Speaker 2: you know that that's a big hot topic these days.
0:47
Speaker 2: So I was really interested because of my podcast to
0:51
Speaker 2: meet doctor Brian.
0:52
Speaker 1: And anyway, it turned out by just good fortune.
0:56
Speaker 2: Susan, his partner, was there and then doctor Brian came
1:00
Speaker 2: by and so we started chatting, and I mean, I
1:04
Speaker 2: was just so engaged in all that he's done. So
1:08
Speaker 2: today we're going to hear his backstory on how he
1:14
Speaker 2: got to where he is today, and we're going to
1:16
Speaker 2: hear all about deep dive into nitrigauxide. But the story
1:21
Speaker 2: I was going to tell you is that so I
1:23
Speaker 2: needed a ride to Los Angeles and I happened to
1:26
Speaker 2: mention to doctor Brian that I was going up to
1:29
Speaker 2: LA after the and right away he offered me a
1:32
Speaker 2: ride with flying back to the air or going back
1:35
Speaker 2: to the airport to fly back to home.
1:38
Speaker 1: So I was just so impressive.
1:39
Speaker 2: Here was a complete stranger and here he was so
1:43
Speaker 2: generous to offer. That turned out my schedule change and
1:47
Speaker 2: we didn't do it, And I actually regret that because
1:49
Speaker 2: I think I would have learned an awful lot in
1:51
Speaker 2: that one hour, just having him one on one that
1:54
Speaker 2: outside of a conference. But anyway, it just shows you
1:58
Speaker 2: the generosity of Brian. And actually I like him so
2:02
Speaker 2: much that I have him in October, well September, but
2:06
Speaker 2: it won't come out until October.
2:08
Speaker 1: First. He'll be the feature column in.
2:11
Speaker 2: My Top Doctor magazine, so I do a monthly column there.
2:15
Speaker 2: So if you are listening to this podcast or watching
2:19
Speaker 2: it today, please check out Topdoctor dot com and you'll
2:23
Speaker 2: see another piece on doctor Brian.
2:26
Speaker 1: So, good morning, Nathan. How are you well great?
2:29
Speaker 3: It's great to see you. I'm doing fantastic.
2:32
Speaker 1: How were you I'm doing great. Are you in Austin today?
2:36
Speaker 4: I am.
2:37
Speaker 3: I'm home for the next couple of days. I live
2:38
Speaker 3: about an hour outside of Austin. But I just flew
2:41
Speaker 3: in from Miami yesterday and headed to New York next week.
2:44
Speaker 1: Yeah, you're on an airplane a lot.
2:47
Speaker 2: So Nathan, you know, Night to Go Outside has become
2:51
Speaker 2: one of the darlings of the longevity movement, and a
2:54
Speaker 2: lot of people, however, I'm shocked, haven't really understood or
2:59
Speaker 2: even know about it. So why don't we start first
3:02
Speaker 2: with how did you get so engaged in an area
3:06
Speaker 2: that is still emerging and evolving as a longevity I
3:12
Speaker 2: don't even want to say a biohap because it really
3:15
Speaker 2: is a scientific breakthrough that people haven't really understood.
3:19
Speaker 1: So it's kind of like inflammation was for many years.
3:23
Speaker 2: If you remember when they first started talking about inflammation,
3:26
Speaker 2: everybody compooted in the medical world, and then suddenly it
3:29
Speaker 2: became this, you know, very important part of the three
3:33
Speaker 2: leged stool of health. Right, So I think Nikagatxa might
3:39
Speaker 2: be the fourth leg. So let's start in the beginning.
3:41
Speaker 2: So what is it that brought you to this awareness
3:45
Speaker 2: of something that's so important and so young at such
3:48
Speaker 2: a young age.
3:49
Speaker 3: Well that takes me back almost thirty years, I know,
3:54
Speaker 3: and you're not that old.
3:55
Speaker 1: So Okay, so thirty years.
3:58
Speaker 3: Means early nineteen Yeah, the late nineties, yeah, late nineties.
4:02
Speaker 1: Early ties. I'm sorry.
4:05
Speaker 3: Yeah. So I was a student at LSU School of Medicine.
4:07
Speaker 3: I was working on a PhD in molecular study of physiology,
4:09
Speaker 3: and a Nobel Prize had just been awarded for discovery
4:11
Speaker 3: of nitric oxide. And honestly, you know, I had a
4:15
Speaker 3: degree in biol chemistry from the University of Texas at Austin,
4:17
Speaker 3: so I was familiar with nitrogen based chemistry. Is obviously
4:20
Speaker 3: nitrocoxide part of the gentrification unification cycle, but it was
4:24
Speaker 3: a new molecule in science or medicine. But obviously it
4:27
Speaker 3: was important because the Nobel Prize had just been awarded
4:30
Speaker 3: for the discovery of nitric oxide as a signaling molecule
4:33
Speaker 3: in the cardiovascer system. And during my PhD work, I
4:36
Speaker 3: was working under a pharmacologist who became my mentor, Martin Feelish,
4:39
Speaker 3: who had worked in the nitrocoxide field for you know,
4:42
Speaker 3: since the early eighties and when it was just first
4:44
Speaker 3: starting to be discovered, and so had I had a
4:48
Speaker 3: chance to meet lou Ignaro, who had just won the
4:50
Speaker 3: Nobel Prize, and you know piqued my interest. It was
4:53
Speaker 3: an exciting time. And you know, nitrocoxide's this gas that's
4:56
Speaker 3: one it's produced, it's gone in less than a second.
4:58
Speaker 3: So we didn't have a lot of analytical tools to
5:01
Speaker 3: measure nitrocoxide production in animals in humans. So part of
5:06
Speaker 3: my PhD was developing these analytical methods where it could
5:08
Speaker 3: detect nitrocoxide and when nitrocoxide is produced, where does it
5:12
Speaker 3: go and what does it become? And how does it signal?
5:14
Speaker 3: Because once it's produced, it's gone in less than a second,
5:17
Speaker 3: So you know, we started trying to figure this out
5:19
Speaker 3: through these nitrocoxide analytical methods that we developed, and we
5:24
Speaker 3: understood the metabolism of nitrocoxide, how it's produced, when it's produced,
5:29
Speaker 3: where does it go, what is it becoming, how does
5:30
Speaker 3: it signal? And then how do we detect nitrocoxide deficiencies
5:34
Speaker 3: in many different diseases from diabetes to hard disease to
5:37
Speaker 3: transplantation surgery. So then we were armed. Our group was
5:41
Speaker 3: armed with really a lot of tools that no one
5:43
Speaker 3: else in the world had. I finished my PhD in
5:46
Speaker 3: less than two years. I think I published two or
5:48
Speaker 3: three first author papers during that time, and then went
5:51
Speaker 3: to Boston Medical Center and was training in the cardiovascu
5:55
Speaker 3: as a a postdoctoral fellow. And then Fredmiradded, the other
5:59
Speaker 3: guy who won the Nobel Rise, recruited me to join
6:01
Speaker 3: faculty of ut Medical School in Houston. And I believe
6:04
Speaker 3: it was two thousand and five, so twenty years ago
6:05
Speaker 3: where I started my own independent research career and you know,
6:09
Speaker 3: again continued our journey of discovery and innovations and you know,
6:13
Speaker 3: started filing patents, patents became issued, and then started making
6:17
Speaker 3: products and starting companies and well, you.
6:19
Speaker 2: Know later, you know, I did watch Blue on.
6:26
Speaker 1: On a tiv on an internet show.
6:28
Speaker 2: I don't know if there's a podcast, But anyway, is
6:31
Speaker 2: he still with you today?
6:32
Speaker 1: I mean, do you collaborate with him?
6:35
Speaker 4: Now?
6:35
Speaker 3: Low is a close friend and colleague, and he's you know,
6:38
Speaker 3: the only remaining surviving member of the Nobel Nobel Aureates.
6:42
Speaker 3: But yeah, no, Look, I'm hosting the Nitric Oxide Society
6:45
Speaker 3: meeting in Austin in April of next year and lose
6:49
Speaker 3: our keynote, lose part of the organizing committee. So you know,
6:52
Speaker 3: he's still active. You know, he's still very active in
6:55
Speaker 3: the nitric oxide community. He's such a wonderful, caring, humble
7:00
Speaker 3: man and really supportive his new investigators and just he
7:03
Speaker 3: has been achieving.
7:05
Speaker 2: I was just about to say to you he was
7:06
Speaker 2: so humble that he didn't even when he was asked
7:09
Speaker 2: about his background, he didn't even mention the Nobel Prize,
7:12
Speaker 2: and the interviewer had to say, well, you're you're omitting
7:16
Speaker 2: one very very important piece of information. So yeah, he
7:21
Speaker 2: had to pull it out of him. I mean, that's
7:22
Speaker 2: that just shows you his humility. So what has happened
7:26
Speaker 2: from then to now in terms of your the scientific
7:31
Speaker 2: awareness of the importance of nitrogoxide.
7:34
Speaker 1: That's you know, it's thirty years. So what what has transpired?
7:38
Speaker 3: Well, today we understand how the human body makes nitrocoxide,
7:42
Speaker 3: we understand what leads to a loss of its production,
7:46
Speaker 3: We understand the symptoms that develop as a loss of
7:48
Speaker 3: nitrocoux as a result of the loss of microcoxid production,
7:51
Speaker 3: and most importantly, we know how to overcome and fix
7:53
Speaker 3: and repair and recapitulate nitrocoxide production and signaling. So, you know,
7:58
Speaker 3: I like to say, those guys has discovered that nitrocoxide
8:02
Speaker 3: is a signaling molecule in the cardiovascar system. But it
8:04
Speaker 3: was really the work of me and my research group.
8:06
Speaker 3: We discovered how to deliver nitrocoxide gas. So we make
8:09
Speaker 3: a solid dose form of nitrocoxide gas. We can deliver
8:12
Speaker 3: this in an outpatient setting. We do this through consumer
8:15
Speaker 3: products and supplements and nutritionals and skincare products. We're developing
8:20
Speaker 3: drug therapy, which was my original kind of goal when
8:22
Speaker 3: I started in academia and medicine was to understand the
8:25
Speaker 3: mechanism disease to the extent that you could start to
8:28
Speaker 3: develop rational therapies. And that's what we're doing. We've got
8:31
Speaker 3: drugs in development for heart disease, got drugs in development
8:34
Speaker 3: for Alzheimer's and dementia. Make a topical drug for diabetic
8:37
Speaker 3: ulcers and non healing wounds. And that's just the start,
8:40
Speaker 3: you know, because now what we know, it's not what
8:43
Speaker 3: we think. It's what we know that there's not a
8:46
Speaker 3: single condition or disease indication where nitrocoxide at the right
8:49
Speaker 3: dose at the right time and the right patient would
8:51
Speaker 3: not be beneficial. And so the future of medicine, health wellness,
8:57
Speaker 3: human optimization is absolutely dependent upon adequate production of mitrocoxae,
9:02
Speaker 3: and we know how to do it better than anybody
9:03
Speaker 3: in the world. And that's what we're doing. When you
9:06
Speaker 3: say we, what do you mean we mean collectively? You know,
9:10
Speaker 3: I never say I know many of the patents. I'm
9:13
Speaker 3: on the sole in vendor on these patents, but you know,
9:15
Speaker 3: it's a team I had, you know, when I was
9:17
Speaker 3: in academia, had you know, research fellows, I had postdocs,
9:21
Speaker 3: I had faculty and staff that work with me in collaboration.
9:25
Speaker 3: So I never take credit for this solely. And then
9:28
Speaker 3: when I say we, now, you know, I have several
9:30
Speaker 3: companies and executives within the companies, there's collaborators, there's you know,
9:35
Speaker 3: clinical trial sites that run our clinical trials. So I
9:38
Speaker 3: never say I because it's just not part of my fabric.
9:42
Speaker 5: That's also showing your humility. Well, so, Nathan, why is
9:47
Speaker 5: it that it took so long for this to become
9:52
Speaker 5: something that people are now much more aware of? What
9:55
Speaker 5: do you think has been the reason that has been
9:57
Speaker 5: slowed down even with a Nobel prize back in the
10:00
Speaker 5: late nineties.
10:02
Speaker 3: Well, I think there's several reason. Number One, on average,
10:05
Speaker 3: it takes about seventeen years for new discoveries to become
10:08
Speaker 3: so called standard of care or mainstream correct. Nitrocoxide is
10:12
Speaker 3: only about a fifty year old. Molecule was first described
10:15
Speaker 3: in nineteen seventy seven fred Mirad's paper showing that organic
10:19
Speaker 3: nitrates like nitroc listenm and metabolized into nitrocoxide and then
10:22
Speaker 3: that leads to vasodilation. That's how these drugs work for angeline.
10:27
Speaker 3: And then in nineteen eighty it was discovered by Bob
10:29
Speaker 3: Firtscott that the cells along our bud vessels produce this
10:32
Speaker 3: nitrocoxide molecule. So that was the initial lag. It just
10:36
Speaker 3: takes time. It has to stand the test of time
10:39
Speaker 3: and for these experiments to be reproducible by other groups.
10:43
Speaker 3: And then the other big I think lag and acceptance
10:46
Speaker 3: is there's been no major developments or innovations in nitrocoxide
10:49
Speaker 3: drug therapy. When I started in the field in the
10:52
Speaker 3: late nineties, every big pharmaceutical company and biotech company had
10:55
Speaker 3: a nitrocoxide pipeline of drugs. The reason they failed was
11:00
Speaker 3: they were using the wrong target, they were using the
11:02
Speaker 3: wrong strategy, and they were putting nitrocoxide linker molecules or
11:07
Speaker 3: nitrocoxide active drugs on parent molecules like COX two inhibitors
11:10
Speaker 3: or aspirin or insets, and you know you have to
11:14
Speaker 3: you have to cleave that nitroester bond, and there's consequences
11:17
Speaker 3: to that. So these weren't These drugs weren't safe. And
11:20
Speaker 3: then you know, in the nineteen eighties, late eighties, early nineties,
11:23
Speaker 3: it was starting to develop nitrocoxide therapy for innoltive therapy
11:27
Speaker 3: for premature babies born with pullman or hypertension. So now
11:31
Speaker 3: clinically that's been used for more than you know, thirty
11:33
Speaker 3: or forty years and save millions of babies' lives that
11:35
Speaker 3: are born premature. But then that's where the clinical innovation
11:39
Speaker 3: really stopped. Because nitrocoxide is a gas. How do we
11:43
Speaker 3: create a solid dose form of nitrocoxide that we can
11:45
Speaker 3: deliver in an outpatient setting. That's really the riddle that
11:49
Speaker 3: I saw, because my patents are on the method of
11:51
Speaker 3: making a solid dose form of nitrocoxide gas. So we
11:55
Speaker 3: make we deliver nitricoxide either topically through our orals or
11:58
Speaker 3: through an organ disintegrating tablet or other technology. And the
12:01
Speaker 3: whole basis of what I do is if your body
12:03
Speaker 3: can't make nitrocoxide, then we got to give it for you. Right,
12:07
Speaker 3: it's a hormone. It's like estrogen and testosterone. So if
12:10
Speaker 3: men or women can't make testosterone or estrogen perspectively, we
12:14
Speaker 3: give them testosterone. We give them the actual molecule. And
12:18
Speaker 3: so what we do is we give nitrocoxide gas. Where
12:21
Speaker 3: all of the companies out there can't do this, they
12:23
Speaker 3: don't do it and so their products don't work.
12:26
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13:12
Speaker 3: Because we're never deficient in argentine or cicillin, and we're
13:15
Speaker 3: not deficient in a dead beat powder. So taking these
13:18
Speaker 3: products is not going to help in nitrocoxide production.
13:21
Speaker 1: I think that's very important what you just said, because
13:23
Speaker 1: a lot of.
13:24
Speaker 2: People I know take L rgenine and they forget to
13:27
Speaker 2: take the L siculine with it. But even what you're
13:31
Speaker 2: just saying is if you're taking both of those, you know,
13:33
Speaker 2: doing it the combo, it's still not going to produce
13:36
Speaker 2: the nitrogoxide.
13:38
Speaker 1: That you can be used.
13:39
Speaker 3: Well, that's because they don't understand the biochemistry, and that's
13:43
Speaker 3: why companies are really doing their customers of disservice and
13:46
Speaker 3: they're killing an industry. They're killing the nitrocoxide field because
13:50
Speaker 3: don't work and then the consumer or the patient goes
13:53
Speaker 3: Nitrocoxide must not be that important because these products didn't
13:56
Speaker 3: help me. But look, the enzyme that converts argentines to
13:59
Speaker 3: nitrol coxide is broken. And furthermore, el citylene is a
14:04
Speaker 3: byproduct of nitrocoxide production. It is not a precursor. Right,
14:08
Speaker 3: So for me, it's it's an easy litmus test. If
14:10
Speaker 3: you're looking for products in your supplement store and that
14:12
Speaker 3: product has il argentine or el CityLine in it. Then
14:15
Speaker 3: just dismiss it because these the people who are selling
14:18
Speaker 3: you that product do not understand the basic biochemistry the
14:21
Speaker 3: enzymology of how nitrocoxide is produced. So that's an easy
14:25
Speaker 3: litmus test. So save your money, put the product back
14:28
Speaker 3: on the shelf.
14:29
Speaker 2: And then what sorry the interpret what about it if
14:32
Speaker 2: you added glute tocione, if you get a transderal glute
14:36
Speaker 2: to scion, because I know glue tocion is very difficult
14:39
Speaker 2: to absorb otherwise, uh maybe through ivs, but it's only
14:43
Speaker 2: a short lived. So let's just say you're doing a
14:46
Speaker 2: you know, an absorbable glutathion, which is a very rare
14:49
Speaker 2: thing to find. Does that help the old argentine and
14:52
Speaker 2: L siculine and with glutathione added to produce more of
14:57
Speaker 2: a nitrogoxide result?
15:00
Speaker 3: Not necessarily? Now, not necessarily because here's the problem. The
15:03
Speaker 3: nitrocoxide synthase enzyme is what we call a homeo dimer,
15:07
Speaker 3: So it's two twins that come together. Okay, these these
15:10
Speaker 3: these enzymes have to undergo a conformational change to transfer
15:13
Speaker 3: the electrons from rgenine to make nitrocoxide, and then it spits
15:16
Speaker 3: out citrilline as a byproduct greate limiting step in the
15:20
Speaker 3: uncoupling of that enzyme oxidation of tetrahydroboptria. So more glue
15:25
Speaker 3: de thione, more antioxidant antioxidant capacity, But just by increasing
15:30
Speaker 3: glue to thion doesn't prevent oxidation of tetrahydroboptrin. There's a
15:34
Speaker 3: different redox potential for glue de thione than a scorbic acid,
15:39
Speaker 3: than alphalopoic acid, than tetrahydroboptrin, to all other antioxidants, whether
15:44
Speaker 3: fat soluble, water soluble, enzymatic antioxidants, there's a redox potential
15:50
Speaker 3: that's required to prevent the extraction of electron from all
15:53
Speaker 3: those molecules. So the simple answer is maybe, but not
15:58
Speaker 3: necessarily right.
15:59
Speaker 2: So basically what you're saying, Nathan, is if you have
16:03
Speaker 2: an l arginine and even if you've added the l
16:06
Speaker 2: ciculine and you're doing that combo, forget about it.
16:08
Speaker 1: It's not going to do. It's not going to do
16:11
Speaker 1: what they're the manufacturers are.
16:14
Speaker 3: Look look, because there's very defined biochemistry. Right, there's what
16:19
Speaker 3: we call the Michalis constant. And this may get too
16:21
Speaker 3: technical for young but I think it's very important concept.
16:23
Speaker 3: There's a certain concentration of a molecule that's required to
16:28
Speaker 3: theoretically saturate fifty percent of the binding sites to activate
16:31
Speaker 3: that somatic reaction. The Machaus concept rail argentine is five micromolar.
16:36
Speaker 3: Even the sickest of sickest people, we've got one hundred
16:39
Speaker 3: to two hundred micromolar. What does that mean? We have
16:41
Speaker 3: twenty to forty times excess l argen. Then what's needed
16:45
Speaker 3: to bind to the enzyme to make nitrocoxet. We're never
16:48
Speaker 3: deficient in largen. It's a semi essential amino acid. We
16:51
Speaker 3: get it from the breakdown of protein, whether it's animal
16:53
Speaker 3: or plant protein, and we make it through the U recycle.
16:56
Speaker 3: The partially recycle is present in every cell in the
16:59
Speaker 3: human body, and we're easily making margining. We're constantly making situation.
17:03
Speaker 3: We're never deficient in these inzie and these amino acids,
17:06
Speaker 3: So it makes no sense to supplement. Why supplement something
17:10
Speaker 3: that you're not deficient.
17:11
Speaker 1: That you already have.
17:14
Speaker 2: So Nathan, go back for a moment and just give
17:18
Speaker 2: everybody a very good, short and easy to understand definition
17:25
Speaker 2: beyond it being a molecular gas. But take us a
17:30
Speaker 2: little bit deeper to what is nitricoxide.
17:33
Speaker 3: Well, it's a signaling molecular It's first discovered to be
17:36
Speaker 3: a vasodilator. So when it's produced in the lining and
17:39
Speaker 3: the blood vessel, that relaxes the smooth muscle around the
17:41
Speaker 3: blood vessels and it leads to vasodilation. So now we
17:44
Speaker 3: were getting increased oxygen nutrient delivery to downstream blood vessels.
17:50
Speaker 3: It's the signal that tells our own stem cells to mobilize.
17:52
Speaker 3: So if you have adequate nitrocoxide, you have more stem
17:55
Speaker 3: cells in circulation on you know, autologous our own stem cells.
18:00
Speaker 3: It activates an enzyme in our nucleus called telomerase, which
18:03
Speaker 3: prevents our telomeres from shortening, so shorter telomere, shorter life span,
18:07
Speaker 3: longer telomere's line, longer life span. And then the other
18:11
Speaker 3: important thing about longevity is it induces mitochondria biogenesis and
18:14
Speaker 3: it improves the efficiency of oxygen utilization to make sailor
18:18
Speaker 3: energy or ATP. So if you think about that, if
18:21
Speaker 3: you don't if you can't make nitroc oxide, you lose
18:24
Speaker 3: the regulation of blood flowing, develop eed high blood pressure.
18:27
Speaker 3: Insulin resistance, you have mitochondrial dysfunction, you have shorter telomeres,
18:32
Speaker 3: and you don't repair and replace dysfunctional cells because you
18:35
Speaker 3: don't have any stem cells in circulation. Do you want to?
18:38
Speaker 3: You want to? You want to lead to human optimization
18:40
Speaker 3: and biohacking and longer, healthier life free of disease. I
18:43
Speaker 3: mean you have to start at nitrocoxide. That is the foundation.
18:47
Speaker 3: There are other things you have to address, but without
18:49
Speaker 3: added oxide production, nothing else is going to optimize you.
18:53
Speaker 1: And this is so compelling.
18:54
Speaker 2: And then that means that you know, adding all the
18:56
Speaker 2: other you know, the five legged stool of you know
19:00
Speaker 2: of a diet and I mean nutrition and sleep and
19:04
Speaker 2: stress and all the things that go into a go
19:08
Speaker 2: into a healthy lifestyle that you actually without nitrogoxide, all
19:12
Speaker 2: of those things are not going to be nearly as effective. Right.
19:17
Speaker 2: You need the nitrogoxa kind of like the foundation, like
19:20
Speaker 2: building a house.
19:21
Speaker 1: That's your foundation.
19:23
Speaker 3: And yes, nitrocoxide is not going to replace sleep, It's
19:26
Speaker 3: not going to replace you know, a good diet. I
19:28
Speaker 3: mean it's a two way street. If you have addiput
19:31
Speaker 3: nitrocoxide production, you have good rest. You can improve microoxide
19:35
Speaker 3: production improves them sol mobilization. So you're gonna rest and repair,
19:38
Speaker 3: right if you need it. More diet, You're gonna high sugar,
19:42
Speaker 3: carbohydrates and you know all that. It's it's going to
19:45
Speaker 3: continue to deplete, deplete your body availability to make nitrocoxide.
19:48
Speaker 3: Taking oxide products isn't going to help you. I mean
19:52
Speaker 3: it will help you, but it's not gonna You still
19:54
Speaker 3: have to change your diet and do the things that
19:57
Speaker 3: you know lead to better natural production nitrocoxide.
20:00
Speaker 2: Right, So this is a collaboration, but it is something
20:02
Speaker 2: that is important to look at.
20:04
Speaker 1: So how do you get a baseline?
20:06
Speaker 2: How do you know what your nitrogoxide level is if
20:08
Speaker 2: you're starting out on a nitric oxide journey.
20:13
Speaker 3: Well, you know, unfortunately there's no biomarkers like blood labs
20:16
Speaker 3: and we can draw and give you a number of
20:18
Speaker 3: your nitrocoxide because again, once it's produced, it's metabolized in
20:21
Speaker 3: different metabolites. We've done this for you know, twenty five
20:24
Speaker 3: thirty years in the research lab, but unfortunately it's not
20:26
Speaker 3: done clinically. So what we do is we rely on symptoms.
20:30
Speaker 3: So the first sign and symptom to develop if your
20:33
Speaker 3: body becomes compromising stabilities to use. Nyitrocoxide is a rectile dysfunction.
20:37
Speaker 3: And this is just in mail. It's a female and
20:40
Speaker 3: if you think about it, to get an erection, either
20:42
Speaker 3: a penile or clinical label erection, we have to increase
20:46
Speaker 3: blood flood flood, not ngorgement, So you have to dilate
20:49
Speaker 3: the blood vessels. Nitrocoxide dilates the blood vessels. If you
20:52
Speaker 3: can't make nitrocoxide, we don't get vasodilation, we don't get engorgement.
20:56
Speaker 3: And that is a rectile dysfunction. It's called the canary
20:59
Speaker 3: and the coal mine, but because it it is the
21:01
Speaker 3: canary in the coal mine, because if you have in
21:03
Speaker 3: the field of dysfunction in the vascular bed of your
21:06
Speaker 3: sex organs, that same dysfunctions occurring in your heart, in
21:09
Speaker 3: your brain, in your lungs, in your liver. It's a
21:11
Speaker 3: systemic disease that manifests first when we're trying to dilate
21:15
Speaker 3: the blood vessels on demand. And then number two, your
21:18
Speaker 3: blood pressure starts to go up because without adequate nitrocoxide,
21:22
Speaker 3: now we've got the same volume of blood going through
21:24
Speaker 3: smaller blood vessels and pressure does out. Number three you
21:27
Speaker 3: start to get insulin resistance in metabolic disease. Nine out
21:31
Speaker 3: of ten Americans are metabolically unhealthy. Number four, you can't
21:35
Speaker 3: maintain an exercise regimen because if you can't dilate the
21:37
Speaker 3: blood vessels to the heart or the skelele to muscle
21:40
Speaker 3: when you're exercising, you tire, You get lactic acid build up,
21:44
Speaker 3: and you can no longer maintain that exercise regional. And
21:46
Speaker 3: then number five, you start to get brain foged, mold,
21:49
Speaker 3: cognitive impairment, dementia, and eventually Alzheimer's. So those are the
21:53
Speaker 3: things that you should pay attention on. And you know,
21:56
Speaker 3: the analogy I use is that you're, you know, our smartphone.
22:00
Speaker 3: When we look at our smartphone and we see the
22:02
Speaker 3: red light come on here that our batteries low, people
22:04
Speaker 3: pay and they go, oh shit, I got to charge
22:06
Speaker 3: my battery. Ed is your red light coming on? Senior batteries?
22:10
Speaker 3: High blood pressure, insular resistance, exercise intolerance, cognitive brain full
22:16
Speaker 3: that's your body telling you, hey, I need some nitrococide.
22:19
Speaker 3: I'm getting low, and so pay attention. Your body's always
22:22
Speaker 3: talking to you. He's going to pay attention.
22:25
Speaker 2: But yet, Nathan, if you're going to a even a
22:28
Speaker 2: functional medicine doctor, how often if they have these symptoms,
22:33
Speaker 2: are they going to tell someone to go get nitrogoxide?
22:36
Speaker 2: You know, talk to me doctor Brian and go to
22:39
Speaker 2: N one oh one your company and you know, start
22:42
Speaker 2: using the product. So you know in your experience, are
22:45
Speaker 2: people that are in your world, in your wheelhouse are
22:49
Speaker 2: they are they advocating that as a solution for those
22:53
Speaker 2: kinds of symptoms.
22:55
Speaker 3: You know, we're making some progress, but here's the problem.
22:58
Speaker 3: I mean, as this market is expanding and the awareness
23:01
Speaker 3: around nitrocoxide is growing, more companies are coming in trying
23:06
Speaker 3: to sell a nitrocoxide product. Yes, doctors will recommend it
23:10
Speaker 3: because they've got sales people in there. They hear a
23:12
Speaker 3: webinar or here's something they go, well, let me try
23:14
Speaker 3: this nitrocoxide pid or I saw a commercial on TV.
23:17
Speaker 3: And then they say, well to take this be product
23:19
Speaker 3: and then come back. Whether patient comes back and they go, well,
23:22
Speaker 3: this didn't help me, and then we lose. We lose
23:25
Speaker 3: the conversation. And it's not nitrocoxide didn't work for that patient.
23:29
Speaker 3: It's because that product cannot, did not and will not
23:32
Speaker 3: ever produce nitrocoxide in that patient because that product doesn't
23:36
Speaker 3: address the root cause of their deficiency, because they're either ignorant,
23:39
Speaker 3: and ignorance is fine, it's just a lack of knowledge,
23:42
Speaker 3: or they're deceptive and fraudulent, which any companies out there
23:46
Speaker 3: who are intentionally defrauding their customers because it's a it's
23:50
Speaker 3: a cheaper product that they can sell for higher profits
23:53
Speaker 3: and it cannot and will not produce nitrocoxide. And I
23:56
Speaker 3: think that's why these conversations are so important, because all products,
23:59
Speaker 3: not just notox have can be based on science and
24:02
Speaker 3: it has to be personalized. And that's why I like
24:04
Speaker 3: the functional integrative docs because they have time to spend
24:07
Speaker 3: with their patients to get an insight into their lifestyle,
24:11
Speaker 3: their diet, what are their deficiencies, what are their talks
24:13
Speaker 3: and exposures, and then develop personalized therapies for them. Well,
24:18
Speaker 3: if you go to standard allopathic doc, you get five
24:20
Speaker 3: minutes with you and which is oh, you got ed.
24:23
Speaker 3: Here's a sildenti fil.
24:24
Speaker 1: Or vitrop look at, give me some viagra, an.
24:30
Speaker 3: Acid hypn or arb for your hypertension. Here's some met
24:33
Speaker 3: foreman for your diabetes. And here's the ambient because you
24:37
Speaker 3: can't sleep, and then you wake up and you're on
24:38
Speaker 3: a dozen different medications, and people wonder where they're sick. Right.
24:42
Speaker 1: So you mentioned though that you're developing drugs.
24:45
Speaker 2: Now, so how did you cross that bridge to get
24:48
Speaker 2: to the allopathic community and get them to agree to
24:52
Speaker 2: work with you on on nitrogogxide in other words, including
24:57
Speaker 2: nitrogoxat in in an pharmaceutical side of the medical world.
25:03
Speaker 3: Well, I can tell you it was never my intent
25:05
Speaker 3: going into academia to be a developer of dietary supplements.
25:09
Speaker 3: That was never even online radar, right. But because we
25:12
Speaker 3: had developed a way to produce nitrocoxide, and because I
25:15
Speaker 3: knew how to do this through natural products and through
25:18
Speaker 3: food and through modification of the microbiome and affecting the
25:22
Speaker 3: structure and function of the enzyme, we could do this
25:24
Speaker 3: through natural products and through dietary supplements. But the goal
25:28
Speaker 3: all along was to develop drug therapy how to deliver
25:31
Speaker 3: nitro patient setting. So we're not convincing the allopathic community
25:35
Speaker 3: to work with us because they can't because we don't
25:38
Speaker 3: have an FDA drug approved on the market. So what
25:40
Speaker 3: we do is we go to the FDA we have
25:43
Speaker 3: meetings with the FDA. So look, here's what we want
25:45
Speaker 3: to do. We want to go after schemic car disease.
25:47
Speaker 3: Here's our nitric oxide releasing drug that when we take this,
25:51
Speaker 3: we dilate the blood vessels, we relieve the schemic pain
25:54
Speaker 3: known as ANGEL and we can prolong exercise induced agen
25:57
Speaker 3: And by the way, it works better than isosorb by
25:59
Speaker 3: diet nitrade or nitroglycery, and it's safer, so we can
26:03
Speaker 3: miss the FDA. We're gonna design a clinical trial. We're
26:05
Speaker 3: gonna test this in a double blind fall seabook controlled study,
26:08
Speaker 3: and if we hit our endpoints, the FDA agreed that
26:11
Speaker 3: they'll approved this drug, and then we've got a new
26:13
Speaker 3: drug indication for a scheme of card disease. We did
26:16
Speaker 3: the same thing with Alzheimer's. You go all the FDA go. Look,
26:19
Speaker 3: Alzheimer's is a metabolic master of disease. We're developing a
26:22
Speaker 3: nitrocoxet releasing drug that improves glucose ub take that improve
26:26
Speaker 3: the profusion of the brain, overcomes focal a schemia, we
26:29
Speaker 3: don't get misfolding of proteins, and it addresses the root
26:32
Speaker 3: cause of dementia. Alzheimer's. So we're gonna design a clinical trial.
26:35
Speaker 3: We're gonna test it in a placebo controlled randomized clinical trial,
26:39
Speaker 3: and if we hit these endpoints, well, can we agree
26:43
Speaker 3: to approve this drug based on the design of this study.
26:47
Speaker 3: It's we have to go to the FDA, we have
26:49
Speaker 3: to design clinical studies, we have to do the clinical studies,
26:52
Speaker 3: and these are tens of millions of dollars and take many.
26:55
Speaker 1: Many years. I was just about to saying this is very.
26:59
Speaker 3: Cost It's very costly, you know. And I've intentionally avoided
27:04
Speaker 3: private equity money of venture capital money because I don't
27:07
Speaker 3: want these people interfering with the science, because they're more
27:11
Speaker 3: interested in making money than advancing the science. And exactly utually,
27:14
Speaker 3: for me, I'm not doing this for the money. I've
27:16
Speaker 3: made enough money in my career to live happily ever
27:19
Speaker 3: after so I can be bought and I will not
27:21
Speaker 3: be bought. But it's taken me a little bit longer
27:23
Speaker 3: because I have to self fund these studies and go
27:26
Speaker 3: out and raise money from people, individuals who know what
27:31
Speaker 3: we're doing, who understand what we're doing, who understand the
27:34
Speaker 3: global impact if we're successful, not if we're successful when
27:37
Speaker 3: we're successful, how this is going to change the world.
27:40
Speaker 3: And we're not doing it for the money. We're doing
27:42
Speaker 3: it to do the right thing.
27:44
Speaker 2: So I want to ask you, because we talked about
27:47
Speaker 2: the baseline, how do you measure and you said, okay,
27:50
Speaker 2: you look at the symptoms. I wanted a more quantitative
27:54
Speaker 2: measurement when we first met each other, so I asked
27:56
Speaker 2: cal Roy ed Hoy is a good friend of.
28:00
Speaker 1: Mine, and uh, you know, you know who.
28:02
Speaker 2: They are, and I assume that they're doing the glycocalyx
28:06
Speaker 2: and the they have a they have a nitric oxide product,
28:10
Speaker 2: and I.
28:11
Speaker 3: Asked them, they don't have a nitrocoxide product. They get
28:14
Speaker 3: potassium nitrate in a capsule. Nitride is not nitrocoxide. Okay,
28:19
Speaker 3: that's the record that I want to always keep.
28:21
Speaker 1: String Okay, sorry about that.
28:23
Speaker 3: We can electrocoxide product, but it's not a product.
28:30
Speaker 2: But however, they used the strips and I just had
28:33
Speaker 2: one right here, which I did right this morning, uh before,
28:37
Speaker 2: but I did it after I ate and I realized
28:39
Speaker 2: you slosed to do these on an empty stomach, and
28:41
Speaker 2: I so I probably I didn't do it right.
28:43
Speaker 1: But this is the one that Ed sent me and you.
28:47
Speaker 2: Said you developed those strips twenty five years ago and
28:51
Speaker 2: that you don't really use them as a measurement.
28:54
Speaker 1: So why is that? And and you know.
28:57
Speaker 2: If you wanted just a quick like, okay, how am
29:00
Speaker 2: I doing? And you know, yeah, I don't have any
29:03
Speaker 2: symptoms that you just described. I'm perfectly uh, you know,
29:07
Speaker 2: seemed perfectly fine. But I want to know, you know,
29:10
Speaker 2: is this product that I take, which I take your
29:12
Speaker 2: lodgingery every day, is this making a difference? And you know,
29:17
Speaker 2: and you know, we are a kind of a quantitative
29:20
Speaker 2: for sure. We always like to compete with each other
29:23
Speaker 2: and know what where what our score is, right, So this.
29:26
Speaker 1: Is one of the ways you do that. So so
29:28
Speaker 1: what else what can we do? If you don't, I'll
29:31
Speaker 1: tell you.
29:32
Speaker 3: I'll tell you the story, the backstory with those test strips.
29:35
Speaker 3: So when I launched my very first product technology, no
29:38
Speaker 3: one knew what nitrocoxide was. And the number one question
29:41
Speaker 3: we had, and we did market uh focus groups in
29:43
Speaker 3: market research, was how do I know if I need it?
29:46
Speaker 3: So the only way to do this, I mean, we
29:48
Speaker 3: could draw blood and that's what we did in the
29:50
Speaker 3: research lab. And I've published over one hundred peeroview papers
29:53
Speaker 3: on mapping out these nitrocoxxide metaboloids. But I thought, well,
29:56
Speaker 3: I can develop a salary test strip. So in two
29:59
Speaker 3: thousand and nine, I developed the first and only non
30:02
Speaker 3: invasive point of care diagnostic for nitrocoxide. And it's that
30:06
Speaker 3: exact same chemistry that's on that test strip. Factorum, we
30:10
Speaker 3: launched them, I filed patents on it, and several years
30:13
Speaker 3: into By the way, it's very old chemistry. It's called
30:16
Speaker 3: the grease reaction. It's probably over one hundred year old
30:19
Speaker 3: known chemical reaction. The chances of getting a patent on
30:24
Speaker 3: that chemistry was very low. So probably in twenty twelve
30:29
Speaker 3: twenty thirteen, when the bills were starting to come into
30:31
Speaker 3: the University of Texas on prosecuting that patent, and because
30:35
Speaker 3: we weren't making money on it, the university wasn't making
30:37
Speaker 3: money on it, agreed, Okay, let's abandon the patent because
30:41
Speaker 3: it's a tool, right you can. If you know what
30:44
Speaker 3: you're measuring, it's a useful tool. If you don't know
30:47
Speaker 3: what you're measuring, it's a deceptive tool. So number one,
30:51
Speaker 3: it is not a nitric oxide test trip. Now there's
30:56
Speaker 3: at least three or four companies out there selling my
30:59
Speaker 3: original salbrate test strips because I banon the patent and
31:02
Speaker 3: they certainly can do it, but they're still using it,
31:05
Speaker 3: and so what they're measuring, it's not measuring nitrocoxide. The
31:09
Speaker 3: chemistry is called the grease reaction. You put acidified sulfonillamite
31:12
Speaker 3: on that test strip, it reacts with nitrite in the
31:15
Speaker 3: saliva and it forms a diazo compound. It turns pink
31:19
Speaker 3: the five hundred and forty enemes, So if it turns pink,
31:22
Speaker 3: it tells us that your saliva's enriched did nitrite. It's
31:26
Speaker 3: nothing to do with nitrocoxide. But if you understand the
31:29
Speaker 3: metabolism sentaro salbrat circuit, that what it's really measuring is
31:35
Speaker 3: do you have the right oral bacteria and if you're
31:38
Speaker 3: getting enough nitrate from your diet, are the bacteria in
31:41
Speaker 3: your mouth on your tongue converting that nitrate into nitrite.
31:45
Speaker 3: That's what we're detecting. But it's also detecting the immune
31:49
Speaker 3: response to an oral infection. So if you have an
31:52
Speaker 3: active oral infection, if you've got infected root canals, if
31:55
Speaker 3: you've got cavitations, if you've got oral dyspiosis and there's
31:59
Speaker 3: an immune rey action occurring, our immune cells, macrophages, neutrophils,
32:03
Speaker 3: and monocytes produced nitric oxide so oxidized to tride in
32:06
Speaker 3: your saliva and you're picking up a local immune response.
32:10
Speaker 3: So the one of the reasons I abandoned that is
32:12
Speaker 3: because we would see people come in with high blood pressure,
32:17
Speaker 3: ten years of rectile dysfunction, they were diabetic, they were obese,
32:20
Speaker 3: they had a fatty fatty liver disease, and was say, here,
32:24
Speaker 3: use this test trip and they would light it up
32:26
Speaker 3: like a Christmas tree. You could see I make plenty
32:29
Speaker 3: nitric oxide and they go, no, we send him to
32:32
Speaker 3: a Dennis. We do a three DCT cone. He's eat
32:35
Speaker 3: up with oral infections. Right, and now we know that
32:38
Speaker 3: most people are walking around with asymptomatic infections and it's
32:42
Speaker 3: a it's a false positive, and it's a very dangerous
32:45
Speaker 3: false positive. So that's why I tell people, if you
32:48
Speaker 3: understand what that's measuring, and now you can interrogate it.
32:51
Speaker 3: If you're low, they're not a false negatives. And that's
32:54
Speaker 3: really if there's any utility to it, if you spit
32:56
Speaker 3: on it and it's low. You're low, you're nitric oxide
32:58
Speaker 3: deficient because you have any field dysfunction. Is it because
33:02
Speaker 3: you don't have the right oral bacteria. Is it because
33:04
Speaker 3: you're not getting enough nitrate from your diet. Is it
33:06
Speaker 3: because you take in acids or your stomach's not making
33:09
Speaker 3: stomach acid? Is it because you have a you know,
33:12
Speaker 3: silent receptor transported blockage in the in the salavary glands,
33:16
Speaker 3: because you have chogrin syndrome. I mean, there's a laundry
33:19
Speaker 3: list of things that could explain why you're nitric oxide defission.
33:23
Speaker 3: But then if you don't understand that, how do you
33:25
Speaker 3: fix it? Then telling you you're low, but don't understand
33:29
Speaker 3: the physiology about chemistry of why you're testing low, and
33:32
Speaker 3: they want to get they think they can fix your
33:34
Speaker 3: problem based on that test trip. I mean, it would
33:37
Speaker 3: be humorous if it wasn't dangerous.
33:40
Speaker 2: That's pretty amazing that you could get a bright pink result,
33:44
Speaker 2: think you're ok, you're great, and yet it's really an
33:47
Speaker 2: oral infection that's causing you to get this bright pink result.
33:52
Speaker 3: You know, and then people just going about their business,
33:54
Speaker 3: they never go see a biological dentist to look deeper.
33:56
Speaker 3: Than an X ray into a CT and realize they
34:00
Speaker 3: have an asymptomatic osteomocrotic infection going on. That's going to
34:03
Speaker 3: cause enormous problems fibromyalgia, autoimmune disease, cancers. I mean, it's
34:09
Speaker 3: bad news.
34:10
Speaker 2: So let's start from the top. Okay, starting at the head,
34:14
Speaker 2: because I'm going to go from the head to the toe. Okay,
34:17
Speaker 2: so let's I'm probably starting with the biggest one of all,
34:20
Speaker 2: which is Alzheimer's because it's the brain.
34:22
Speaker 1: But why don't you start there and say, you know,
34:24
Speaker 1: explain how the influence of.
34:27
Speaker 2: Low nitric oxide can affect the result in the production
34:32
Speaker 2: of of of beta amyloid or let's just say Alzheimer's
34:38
Speaker 2: or dimension.
34:39
Speaker 3: Well, there's a progression of this, right, it's called mod
34:42
Speaker 3: cognitive impairment, called Bastard dementia, Alzheimer's disease exactly just like
34:48
Speaker 3: any any disease, there's a progression. And so if you
34:51
Speaker 3: catch this early on, what do we call it brain
34:53
Speaker 3: fog or MCI mon cognitive impairment. If you look at
34:57
Speaker 3: cerebral blood flow, and you can do this through a
34:59
Speaker 3: functional MRI, you can do it through spec scans, which
35:03
Speaker 3: I like spec scins and doctor Daniel Laman's word, because
35:05
Speaker 3: it really tells us what parts of the brain are
35:08
Speaker 3: perfused in which are not, and so in these mild
35:12
Speaker 3: cognitive impairments, really any neurological disease, there's what's called focal
35:16
Speaker 3: a schemium. So if you look at a spec scan
35:18
Speaker 3: and dementia or Alzheimer's, the prefone of cortex and parts
35:21
Speaker 3: of the brain are don't show up on the spec scin,
35:24
Speaker 3: and that's because that part of the brain is not
35:26
Speaker 3: getting perfused. So it's called vascular dementia. Why because there's
35:31
Speaker 3: a vaster component to the dementia. There's loss of regulation
35:34
Speaker 3: of blood flow. Just like if you lose the regulation
35:37
Speaker 3: of blood flow to the sex organs, they fail. If
35:39
Speaker 3: you lose regulation of blood flow of the brain, it
35:41
Speaker 3: fails and symptoms manifest depending upon which readiers of the
35:45
Speaker 3: brain develop a schemi or hypoxia. And then number two,
35:49
Speaker 3: and you've heard this called Alzheimer's, we called diabetes type three.
35:53
Speaker 3: It's insulin resistance in the brain. So number one, if
35:57
Speaker 3: you're not getting oxygen and nutrients to the parts of
36:00
Speaker 3: the brain and you can't get glucose into the cell
36:03
Speaker 3: for that cell to make ATP or cell your energy.
36:05
Speaker 3: If that's cell to do its job, you get misfolding
36:07
Speaker 3: a protein. And then what is that misfolded protein. We
36:11
Speaker 3: call that tau tangle. We call it amyloid plaque. That's
36:14
Speaker 3: what shows up in the later stages. So how you
36:16
Speaker 3: fix it. You perfuse the brain, You give nitrocoxide, you
36:20
Speaker 3: dilate the blood vessels. In twenty eleven, my research group
36:24
Speaker 3: was the first group in the history of nitrocoxide to
36:26
Speaker 3: show that nitrocoxide is required for insulin signaling. For insulin
36:31
Speaker 3: to do its job, it binds to the instant receptor,
36:32
Speaker 3: starts an intrasidar signaling cascade, activates nitrocoxide production. Nitrocoxide activates
36:38
Speaker 3: glute forourd glute four goes to the membrane brings glucose in.
36:41
Speaker 3: Without nitrocoxide production, glute four never gets the signal. You
36:44
Speaker 3: develop insular resistance. So instant resistance is a symptom of
36:48
Speaker 3: nitrocoxide deficiency. So when we give nitrocoxide to dementia patients,
36:53
Speaker 3: we dilate the bloodvessils, We perfuse the brain. We show
36:57
Speaker 3: the improvement on spec skins and NMRI, and we improve
37:01
Speaker 3: glucose ubtake into the cell. So if we're delivering oxygen,
37:05
Speaker 3: delivering nutrients, activating mitochondric getting glucose into the cell, so
37:08
Speaker 3: the mitochondric can make sailor energy and atp the proteins
37:12
Speaker 3: do their job, the enzymes do their job. You don't
37:14
Speaker 3: get misfolding of proteins. There's no tall tangle, there's no
37:17
Speaker 3: amyloid plaque, and there's no loss of cognition. That's why
37:21
Speaker 3: nitric oxide will be the end the cure to Alzheimer's,
37:24
Speaker 3: and that's why all drugs against Alzheimer's have failed, because
37:28
Speaker 3: amyloid plaque and tall tangles do not cause disease. They're
37:31
Speaker 3: the consequence of disease. And developing drug targets towards the
37:35
Speaker 3: consequence of any disease is a sure failure. And it's
37:39
Speaker 3: unfortunate that companies just spent billions and billions of dollars
37:43
Speaker 3: of taxpayer money on target.
37:46
Speaker 1: I know doctor Gale Brettison, who is the father of.
37:53
Speaker 2: The natural cures to Alzheimer's, which was on my podcast,
37:59
Speaker 2: and he said that same thing.
38:01
Speaker 1: You know that they're just missing what is it forty billion.
38:04
Speaker 2: Dollars or something like that has been spent on Alzheimer's
38:07
Speaker 2: drugs with no success.
38:10
Speaker 1: That that's like shameful and.
38:14
Speaker 3: Sorry, it's very predictable.
38:16
Speaker 1: Yeah, why why have they ignored NITROGOTSA.
38:20
Speaker 2: I mean, if they would be so easy to with
38:24
Speaker 2: the current drugs to now incorporate the knowledge that you're
38:28
Speaker 2: providing and the world you know of medicine is providing
38:32
Speaker 2: with nitrogotxa, why haven't they recognized that and done something
38:35
Speaker 2: about it?
38:37
Speaker 3: Well, Number one, these companies are for profit companies, right,
38:40
Speaker 3: and I have a number of patents on ways that
38:42
Speaker 3: we deliver nitrocoxide. Look, there's many ways to skin a cat.
38:45
Speaker 3: They can, there's other technologies out there. But in big business,
38:50
Speaker 3: there is no money in cures, right, the money and
38:53
Speaker 3: the trillion dollar big form of business is dependent upon
38:57
Speaker 3: monthly recurring revenue, getting people on drug and keeping them
39:00
Speaker 3: on drugs for the rest of em No matter what
39:02
Speaker 3: business you're in, a for profit business has two goals.
39:05
Speaker 3: Get as many customers as you can and retain the
39:07
Speaker 3: customer for as long as you can. Yeah, that's that's
39:10
Speaker 3: the big I.
39:11
Speaker 2: Mean, the drug companies have the best business model that
39:14
Speaker 2: exists in the world because they can't.
39:18
Speaker 1: They basically capture you.
39:20
Speaker 2: You know, you take one drug to help another drug
39:22
Speaker 2: that helps another drug, and you know, so basically, yeah,
39:26
Speaker 2: I mean it's crazy because they you're basically addicted to
39:30
Speaker 2: using pharmaceutical drugs and it's a it's a downward spiral,
39:35
Speaker 2: it's a big black hole.
39:36
Speaker 3: No, it's it's the best business model in the world,
39:39
Speaker 3: multi trillion dollar global economy. But what's the expense. The
39:43
Speaker 3: expense is our own health and drugs have made.
39:48
Speaker 1: Okay, so let's go to the nasal the next I'm
39:51
Speaker 1: heading down south.
39:52
Speaker 2: Okay, so we're going to end up at erectile dysfunction,
39:55
Speaker 2: but I want to make sure we have time to
39:57
Speaker 2: do it.
39:57
Speaker 1: So what about the nasal breathing and and versus the
40:01
Speaker 1: mouth breathing. Why is that beneficial? And what can people
40:04
Speaker 1: do to change their habit?
40:06
Speaker 3: Well, the same enzyme that's found in are endothelo cells
40:09
Speaker 3: that produces nitrocoxide. The nitrocoxide synthase enzyme is also found
40:13
Speaker 3: in our upper airways, the epithelial cells. So we do
40:16
Speaker 3: nasal breathing, it activates these epithilal cells and turns on
40:19
Speaker 3: nitro production. We do dasel breathing, we're actually delivering nitrocoxide
40:24
Speaker 3: gas into the pulmary circulation, so we're dilating the pulmonary arteries.
40:28
Speaker 3: Now we're matching ventilation to perfusion, and we're improving tissue oxygenation.
40:32
Speaker 3: But it's also dilating the bronchiles. So nitrocoxide is a
40:36
Speaker 3: smooth muscle relaxing, relaxes the smooth muscles on the blood vessels,
40:39
Speaker 3: relaxes smooth muscles around the bronchiles. So now we're dilating
40:43
Speaker 3: the bronochiles, dilating the arteries, improving oxygenation. But if the
40:48
Speaker 3: enzyme is uncoupled and not functional, so if you have
40:50
Speaker 3: nithenyal dysfunction, you have epithial dysfunction. And we tested this.
40:54
Speaker 3: We take young healthy individuals do nasal breathing. We can
40:56
Speaker 3: detect nitrocoxide out of the ease heal breath. We take
40:59
Speaker 3: a fifty year old person with EED do nase of breathing.
41:01
Speaker 3: There's no nitrocoxide. So again we have to focus on
41:05
Speaker 3: restoring the function of the nos enzyme. Rgentie didn't go
41:08
Speaker 3: fix it. Beats aren't gonna fix it. Centrally, it didn't
41:11
Speaker 3: go fix it. I have to understand the enzomology about chemistry. Now,
41:16
Speaker 3: if your mouth breathe, not only are you bypassing that
41:19
Speaker 3: nitrocoxide production pathway, but now you're you're completely oxygenating the
41:23
Speaker 3: oral cavity. You're changing the oral microbiome, You're acidifying the saliva.
41:28
Speaker 3: All the nitrocoxide producing bacteria go away, all the pathogens
41:31
Speaker 3: come in. Now you have chronic halatosis, you have an
41:34
Speaker 3: acidic saliva, you have carrious causing bacteria, you have paradonal
41:37
Speaker 3: disease causing bacteria. Performonis gingivite is all the really bad
41:41
Speaker 3: red pathogens you see on dental pathogens and start to
41:46
Speaker 3: show up. And you don't oxygenate at night, And so
41:50
Speaker 3: I mean in ten time increase in all cause mortality
41:53
Speaker 3: through mouthbreathing.
41:54
Speaker 1: So that means.
41:57
Speaker 2: What you do in the daytime, you know, you have
41:59
Speaker 2: to be aware of that, but at night it's when
42:02
Speaker 2: most people really are doing the wrong thing, which is
42:05
Speaker 2: mouth breathing. So tape do mouth taping, which I read
42:09
Speaker 2: about from a number of biological dentists that they're advocating that.
42:14
Speaker 1: So you can buy those you know mouth tapes and
42:17
Speaker 1: use them.
42:17
Speaker 2: Are you advocating that as a as a methodology from
42:21
Speaker 2: night for sleeping.
42:22
Speaker 3: Well, First of all, I encourage anybody who's a mouth
42:25
Speaker 3: breathering to go see an airway specialist, either at an ear,
42:29
Speaker 3: nose and throat doctor or a dentist who's an airway specialist,
42:33
Speaker 3: because you don't want a mouth tape if you get
42:35
Speaker 3: an anatomical obstruction, that's right. And because tape in your mouth,
42:39
Speaker 3: I mean you could literally suffocate. You have to have
42:41
Speaker 3: an airway for them to be oxygen exchange.
42:43
Speaker 1: That's right.
42:44
Speaker 3: Many people have anatomical issues, they have a small mouth,
42:47
Speaker 3: you know, right, they have an obstructed airways. So first,
42:51
Speaker 3: before you ever consider taping your mouth, go do the
42:53
Speaker 3: airway specialists and make sure you don't have an obstructive
42:56
Speaker 3: ay way. But yeah, if you've got if you've got
42:58
Speaker 3: an open airway, mouth taping. I do it occasionally if
43:01
Speaker 3: I'm outside I've got allergies and i feel a little snuffy,
43:04
Speaker 3: but I've got an open airway, so I can do
43:06
Speaker 3: mouth taping and you know, you feel the difference of
43:08
Speaker 3: it the next morning.
43:09
Speaker 1: Yeah, for sure.
43:10
Speaker 2: I started doing it a little bit and it does
43:12
Speaker 2: make a difference, and I think how deep you sleep?
43:15
Speaker 1: All right?
43:16
Speaker 2: So now next is the microbio the oral microbiome. So
43:19
Speaker 2: can you give me a one minute description of how
43:22
Speaker 2: the nitrocoxide influences the oral microbion.
43:26
Speaker 3: Well, the oral microbiome is influencing nitrocoxide production. So we
43:31
Speaker 3: have what's called nitrate reducing bacteria that reduces nitrate to
43:35
Speaker 3: electron reduction to nitrite. And now we swallow it's aliva
43:38
Speaker 3: and make nitrocoxide. But without the bacteria, you know, we
43:41
Speaker 3: lose the cardioprotective benefits of diet, we lose the cardioprotective
43:44
Speaker 3: benefits of exercise. So when we do things like have
43:48
Speaker 3: flouride in our toothpaste, which kills all the bacteria in
43:50
Speaker 3: your mouth. When we use antiseptic mouthwashed, which two out
43:53
Speaker 3: of three Americans usee mouthwashed everythy killing the bacteria, it
43:56
Speaker 3: shuts down nitrocoxide production and your blood pressure goes up.
44:00
Speaker 3: Blood pressure goes up, the number one driver, the number
44:02
Speaker 3: one killer of men and women worldwide. So and we
44:05
Speaker 3: and others a publish that if you destroy the microbiome,
44:07
Speaker 3: it's causal for high blood pressure. So if you're using mouthwashed.
44:11
Speaker 3: You have to stop, use a fluoride free toothpaste, and
44:15
Speaker 3: then start doing things that restore and support the microbiome
44:18
Speaker 3: instead of destroying them.
44:20
Speaker 2: You know, I'm so shocked when I go to these dentists,
44:23
Speaker 2: I do you know, I have a biological I mean,
44:27
Speaker 2: a regular hygiene and they're not. They're more you know,
44:32
Speaker 2: in tune to allopathic approaches of but ye.
44:35
Speaker 7: So you know, they open up their cabinet at the
44:39
Speaker 7: end of a session and they want to give you
44:42
Speaker 7: a goodie bag, you know, to take home, and it's
44:45
Speaker 7: flora tice paste.
44:46
Speaker 1: It's chloro hexacrene or whatever that mouth I mean, it's
44:51
Speaker 1: all the stuff that's so.
44:52
Speaker 3: Bad for you.
44:53
Speaker 2: And then when you do any kind of procedure, they
44:56
Speaker 2: want you to use an antibiotic.
44:58
Speaker 1: And that's the first thing they do when you.
44:59
Speaker 2: Walk is you know, they want It's like it's like candy,
45:03
Speaker 2: and I always stuff them in my pocket.
45:05
Speaker 1: You know, they think I'm taking it, but I never do.
45:08
Speaker 1: But you know, the these are the things to be
45:11
Speaker 1: aware of.
45:12
Speaker 2: I mean, traditionally the dentists you're going to go to
45:16
Speaker 2: most people are not going to biological dentists.
45:19
Speaker 1: So you're going to be offered. And then we still
45:22
Speaker 1: have the government dealing with the fluoride in our water
45:25
Speaker 1: and our and the truth pasted is just a byproduct
45:28
Speaker 1: of that. So it's a it's a it's a slippery slope.
45:32
Speaker 2: I mean, you really, you have to navigate your own
45:37
Speaker 2: journey and make your own decisions. But if anybody that's
45:41
Speaker 2: watching today is still using mouthwash, alcohol based mouthwash, throw
45:47
Speaker 2: it in.
45:47
Speaker 1: The trash, right, get rid of it. And and even
45:52
Speaker 1: what do you think about oil pulling?
45:54
Speaker 3: Is that? Is that?
45:54
Speaker 1: Okay?
45:55
Speaker 3: The coconuta you know, the short answer is, we don't
45:58
Speaker 3: know because we've never done the experiment. But you know,
46:00
Speaker 3: I don't think it's an a septic. I think it's
46:01
Speaker 3: a it's a good practice that many biological dyonists and yeah, recommend,
46:05
Speaker 3: but I don't see any downside to it. But we
46:07
Speaker 3: just don't know.
46:09
Speaker 2: Okay, So the next one down I'm saying would be,
46:12
Speaker 2: uh oh, he's telling me hold on, okay, he's.
46:16
Speaker 1: Telling me we're out of time. Oh dude, Well you
46:19
Speaker 1: know what, Nathan, We're going to have you back. I'm
46:22
Speaker 1: so sorry. I wanted to go down through all the
46:24
Speaker 1: you know, the.
46:25
Speaker 2: The organs and particularly the gut microbione and the heart
46:30
Speaker 2: of course, and well and of course the erectile issue.
46:33
Speaker 1: But we'll make that happen in another session. Are you
46:37
Speaker 1: okay with doing another.
46:40
Speaker 3: I love these conversations. These are very important conversations people
46:42
Speaker 3: I know, and.
46:43
Speaker 1: You're doing such an important thing for all of us.
46:45
Speaker 2: Really, I just before we go, I really want to
46:48
Speaker 2: just tell everybody if you want to order, and I'm
46:51
Speaker 2: not everybody knows I'm not commercial, but when I take
46:55
Speaker 2: a product and I know the difference, I want to
46:58
Speaker 2: share it with other people. And I've been using since
47:00
Speaker 2: I met you a year and a half, a little
47:03
Speaker 2: over a year ago, I've been using your N.
47:06
Speaker 1: One oh one the Lozengers. That's the only product I
47:09
Speaker 1: ever got, But I know you have many others. So
47:12
Speaker 1: go check out.
47:13
Speaker 2: Nathan's website and Tony's our producer is going to put
47:18
Speaker 2: it on the screen for everybody, and my assistant will
47:21
Speaker 2: have it in the show notes. So if you want
47:23
Speaker 2: to order any of his products, you can do so
47:26
Speaker 2: using the affiliate My affiliate code with you right, which.
47:29
Speaker 1: Is gives you a ten percent So I will get
47:32
Speaker 1: you the code.
47:33
Speaker 2: I don't have it right with me today, but we
47:36
Speaker 2: will add that in so that people know how to
47:38
Speaker 2: get your products.
47:39
Speaker 1: So Nathan, thank you so much. And I'm really sorry
47:41
Speaker 1: I have to cut his short, but I love what
47:44
Speaker 1: I think.
47:44
Speaker 2: We covered a lot of ground today and it's very,
47:47
Speaker 2: very compelling information. So what you're doing is you're on
47:50
Speaker 2: a mission and you have not deterred from your path.
47:57
Speaker 2: You are an evangelist of outside and I truly, as
48:02
Speaker 2: one individual, I truly appreciate your passion. So thank you again,
48:06
Speaker 2: and and everybody check out Talk Doctor magazine coming up
48:10
Speaker 2: in about another week or so.
48:12
Speaker 1: Okay, take care.
48:14
Speaker 3: Thank you,