845- Engineered Autologous Esophageal Conduits

Paper Talk · Apr 23, 2026 · 24m

This paper describes the successful development and 180-day testing of a tissue-engineered esophagus in a growing large-animal model. Researchers created these functional grafts by microinjecting a decellularized porcine scaffold with the subject's own muscle-derived cells and fibroblasts, followed by maturation in a specialized bioreactor. This integrated approach, which utilized biodegradable stents and surgical vascularization, resulted in 63% of the subjects reaching the six-month endpoint with restored oral feeding and normal growth. Comprehensive analysis confirmed that the grafts…