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The Western Blot That Promised Hope - Then Vanished
The Western Blot That Promised Hope - Then Vanished
Hope curdled into uncertainty: a postcard-sized western blot, dark bands on pale film, helped launch simufilam into human trials that eventually enrolled nearly seventeen hundred Alzheimer’s patients - then the drug failed completely in Phase III. How did a single image become the hinge between federal indictments, four investigations, and the disappearance of original data, and what still keeps this case unresolved?
In this episode, we follow the timeline from the mid-2000s papers through NIH funding and human trials to the drug’s…
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