688-Microbial Drivers of Colorectal Peritoneal Metastasis

Paper Talk · Mar 24, 2026 · 23m

This research article from Nature Cancer investigates the biological mechanisms driving peritoneal metastasis (PM) in colorectal cancer (CRC). By utilizing single-cell RNA sequencing on matched patient samples, the authors constructed a detailed atlas of the tumor microenvironment across primary and metastatic sites. The study identifies that intestinal microbiota dysbiosis triggers inflammation and the recruitment of specific neutrophils, which facilitates the spread of cancer. Furthermore, the findings highlight a mesenchymal transition in both malignant and mesothelial cells that increases…