1070-Engineering Electrical Synapses for Circuit Editing
Researchers have developed a novel circuit-editing technology called LinCx, which uses engineered electrical synapses to precisely regulate communication between specific brain cells. By modifying connexin proteins from white perch fish, the team created selective hemichannels that only connect with each other, preventing "off-target" interactions with the brain's natural proteins. Through computational modeling and a new screening assay called FETCH, they identified a specific structural motif that ensures these designer synapses remain exclusively heterotypic. The study validated the…
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