460-Hijacking Calvarial Immune Cells for Stroke Therapy
Researchers have developed a novel drug delivery method for central nervous system disorders by hijacking immune cells found in the skull's bone marrow. By injecting drug-loaded albumin nanoparticles directly into the skull bone, these particles are internalized by calvarial myeloid cells that naturally migrate into the brain via skull-meninges microchannels. This approach effectively bypasses the blood-brain barrier, allowing for targeted therapeutic transport to brain lesions during conditions like ischemic stroke. Preclinical studies in mice demonstrated that this technique achieves…
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