1203-Epigenetic Routes to Cancer Cell Camouflage
This article discusses how cancer cells utilize whole-genome doubling (WGD) to facilitate immune evasion through a specialized process known as camouflage. Research indicates that while doubled genomes initially trigger immune responses, these malignant cells eventually undergo metabolic and epigenetic rewiring to hide from the immune system. Specifically, the accumulation of succinate inhibits key enzymes, leading to the downregulation of antigen presentation machinery that would otherwise alert T cells. This transformation allows tumors to transition from an immune-inflamed state to a cold…
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