513-Beige Fat Identity of Blood Pressure

Paper Talk · Feb 17, 2026 · 14m

Ablating Prdm16 in mouse adipocytes causes a loss of beige fat identity, leading to vascular remodeling, fibrosis, and hypertension. This process is driven by the derepression of QSOX1, a secreted enzyme. Deleting Qsox1 prevents these cardiovascular defects in mice.

References:

Koenen M, Becher T, Pagano G, Del Gaudio I, Barrero JA, Montezano AC, Ruiz Ortiz J, Lin Z, Gómez-Banoy N, Amblard R, Schriever D, Kars ME, Rubinelli L, Halix SJ, Huang Cao ZF, Zeng X, Butler SD, Itan Y, Touyz RM, Di Lorenzo A, Cohen P. Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated…