1480-Synthetic Wnt Organizers Pattern Human Kidney Organoids
This research article describes the development of synthetic organizers to improve the structural organization of human kidney organoids. While natural human kidneys use WNT signaling boundaries near the collecting duct to guide nephron patterning, lab-grown organoids typically lack this spatial guidance, resulting in disorganized tissues. Scientists identified that a specific WNT11-WNT9B boundary establishes the necessary polarity for proper development in embryos. By engineering WNT-secreting cellular organizers and placing them next to organoids, the researchers successfully broke radial…
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