796-DIAMOND DeepClust for Protein Clustering
The paper introduces DIAMOND DeepClust, an ultra-fast software tool designed to cluster billions of protein sequences across the global biosphere. By employing a cascaded clustering method and optimized alignments, it enables planetary-scale organization of the "protein universe" while maintaining high sensitivity at low sequence identity. Researchers successfully used the tool to group 19 billion sequences into manageable clusters, significantly expanding the known diversity of protein families compared to existing databases. This massive reduction in data complexity helps accelerate…
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