1655-Tumor Immune Microenvironment Remodeling
This research presents a longitudinal pan-cancer atlas that maps the dynamic evolution of the tumor immune microenvironment (TIME) during checkpoint inhibitor therapy. By analyzing single-cell data from hundreds of patients, the authors identified four distinct immune states that are conserved across different types of malignancies. Their findings reveal that the direction of microenvironmental remodeling during treatment is a more accurate predictor of clinical success than the tumor's initial pre-treatment state. Specifically, transitions toward B cell-enriched or inflamed states correlate…
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