802-Memory T Cell Aging and Rejuvenation
This review explores how aging transforms the T cell landscape, leading to a decline in immune flexibility and increased vulnerability to disease. The authors detail how the progressive atrophy of the thymus reduces the production of new naive T cells, while lifelong exposure to pathogens causes the remaining memory T cell pool to become highly specialized but functionally constrained. These shifts are driven by complex molecular mechanisms, including telomere shortening, mitochondrial dysfunction, and epigenetic remodeling, which collectively promote a state of chronic low-grade inflammation…
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