341-Cystine and GPX4 Drive ILC2 Pathogenicity
The article focuses on the metabolic vulnerabilities of immune cells involved in allergic airway diseases like asthma. The study investigates how allergen-induced Innate Lymphoid Cells (ILC2s) and T helper type 2 (Th2) cells adapt their metabolism to survive in inflammatory environments. A central finding is that these pathogenic cells rely on cystine-driven glutathione (GSH) synthesis to activate antioxidant systems, specifically GPX4 and TXNRD1, which confer resistance to a type of cell death called ferroptosis by counteracting toxic lipid peroxidation. This redox balance is essential for…
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