1250-Mapping Microglial Morphology in the Aging Brain
This research uses high-resolution spatial transcriptomics and imaging to investigate how the physical shape of microglia relates to their genetic activity in the aging brain. By mapping mRNA molecules within individual cells, the authors discovered that a cell’s morphology does not always match its transcriptomic state, challenging the traditional belief that specific shapes strictly define certain functions. The study identifies a unique set of process-enriched genes that can predict whether a cell is branched or amoeboid, highlighting how the location of genetic material influences…
The skinny
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