082-Single-cell spatial atlas of the human cerebral cortex

Paper Talk · Sep 22, 2025 · 24m

This article presents a comprehensive spatial transcriptomic atlas of the human cerebral cortex at single-cell resolution. The researchers utilized advanced sequencing technologies, snRNA-seq and subcellular-level spatial transcriptomics, to map 14 distinct cortical regions from multiple donors. This research revealed a detailed cellular and molecular architecture, characterizing the organization, expression patterns, and spatial arrangements of various neural cell types, including glutamatergic and GABAergic neurons. Furthermore, the study investigated cell-cell interactions, regional…