1694-Stem Cell Gene Module Map and Cancer Stem Cells
By constructing a gene module map, researchers successfully linked transcriptional programs of embryonic stem cells (ESCs) and adult tissue stem cells, discovering that a specific ESC-like gene signature is frequently activated in aggressive human epithelial cancers and serves as a powerful predictor of metastasis and mortality. This embryonic program can be independently reactivated by the c-Myc oncogene, which acts as a molecular switch to silence adult tissue stem signatures and drive cell-autonomous tumor initiation in adult epithelial cells without causing genomic instability…
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