1567-RNA Structures Regulate Norovirus Replication
This research characterizes the complete RNA secondary structure of the murine norovirus genome within infected cells, identifying a complex network of regulatory motifs located primarily in protein-coding regions. By using high-throughput chemical probing and evolutionary analysis, the authors discovered that these structured RNA elements are highly conserved and essential for the viral life cycle. Specifically, two structures, lowSS1 and lowSS10, were found to act as translational regulators that fine-tune the production of viral proteins. Disruption of these motifs through synonymous…
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