135-PitNET Heterogeneity and Immune Remodeling

Paper Talk · Oct 13, 2025 · 17m

This article details a comprehensive study of Pituitary Neuroendocrine Tumors (PitNETs) using integrated single-cell RNA sequencing and spatial transcriptomics to understand tumor heterogeneity and progression. The research analyzes over 177,000 cells across 57 tissue samples, identifying distinct tumor populations and characterizing the reconfiguration of the tumor microenvironment (TME). Key findings include the identification of an aggressive tumor cluster (ACTHAgg) associated with elevated p53-mediated proliferation and a higher Trouillas classification, and the enrichment of SPP1+ tumor…