1464-Metabolic Reprogramming in Ischemic Stroke

Paper Talk · Aug 20, 2026 · 24m

This research introduces Metabolic Reprogramming in Ischemic Stroke (MRIS) as a unifying framework that redefines stroke as a systemic bioenergetic failure rather than a localized vascular event. The authors describe a chronological progression of damage, beginning with an acute glycolytic crisis and energy collapse that transitions into a subacute "lipid storm" driven by toxic peroxidation. This metabolic shift impacts various cell types, turning astrocytes and microglia from neural supporters into drivers of neuroinflammation through metabolite accumulation. Crucially, the text highlights a…