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The Heart Pill That Lived Inside the Brain for Decades
The Heart Pill That Lived Inside the Brain for Decades
A single white pill, approved in 1964 to calm overworked hearts, concentrates in the brain at up to 33:1 versus the blood - a fact hidden in pharmacology data for decades. How did a heart drug come to live almost entirely in the mind, and what have clinicians and patients been unaware of all this time?
In this episode, we tell the history of propranolol from its design by James W. Black to its broad clinical use and surprising brain accumulation, asking how a molecule intended for the heart quietly became a neuroactive presence.
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