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Multiple System Atrophy: Multimodal Biomarkers and Clinical Phenotypes
This review article explores Multiple system atrophy (MSA), a rare and aggressive neurodegenerative disease defined by the buildup of α-synuclein protein. The authors examine the shift toward a two-compartment model of the illness, which suggests that while protein aggregates in glia are a hallmark, neuronal damage is the primary driver of decline. Diagnosis remains a significant hurdle because definitive confirmation currently requires postmortem analysis, prompting a search for reliable living indicators. The text evaluates the effectiveness of multimodal biomarkers, including structural…
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