582-The Hallmarks of Cancer
This review by Douglas Hanahan synthesizes twenty-five years of research into the hallmarks of cancer, a conceptual framework used to organize the vast complexities of the disease. The author categorizes the mechanistic foundation of cancer into four distinct dimensions: acquired functional capabilities, enabling phenotypic characteristics, specialized cells within the tumor microenvironment, and systemic interactions. The updated model identifies nine hallmark capabilities, such as sustaining proliferative signaling and evading immune destruction, alongside five enabling traits like genomic…
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