907-Spatiotemporal of Postnatal Brain Vascularization

Paper Talk · May 6, 2026 · 21m

This research introduces LAMBADA, a comprehensive 3D anatomical atlas designed to map the postnatal development of the mouse brain with high temporal precision. By integrating light-sheet microscopy, MRI data, and spatial transcriptomics, the authors identified three distinct stages of cerebral vascularization: isometric expansion, regional specialization, and network refinement. Early growth is primarily driven by hypoxia-sensing pathways, whereas later stages align with neuronal maturation and the onset of sensory-driven activity. This resource reveals that vascular density is not a uniform…