1372-Whole-Cell Digital Twin Simulations of Organelle
Researchers have developed a whole-cell digital twin framework that bridges the gap between live-cell imaging and computational simulation to model intracellular organelle dynamics. By integrating 4D lattice light-sheet microscopy with particle-based simulations, the study creates spatially accurate models of mitochondrial networks and their transport along microtubules. These digital twins successfully predict how mitochondria react to cytoskeletal disruptions and stress without requiring the recalibration of parameters. A key discovery reveals that microtubule topology acts as a structural…
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