195-wellDR-seq Decodes Breast Cancer Genotype and Phenotype
This study introduces wellDR-seq, a novel, high-throughput method for simultaneously co-profiling single-cell whole genomes and transcriptomes, which offers superior performance compared to previous methods. This technique was applied to analyze Estrogen-Receptor-positive (ER+) breast cancer tumors, enabling the identification of potential luminal hormone-responsive cells as the cell of origin and tracing clonal lineages. The research further examines genotype-phenotype relationships, finding that while large copy-number alteration (CNA) segments show near-linear correlations with gene…
The skinny
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