1665-PLA2G2D Regulates Anti-Tumour Immunity
The paper investigate tumor-draining lymph nodes (TDLNs) and their critical role in regulating systemic anti-tumour immunity and patient prognosis. Researchers discovered that PLA2G2D, an immunosuppressive protein produced mainly by macrophages in the TDLN paracortex, curtails the early proliferation and activation of CD8+ T cells. Patients experiencing disease recurrence exhibit higher levels of these PLA2G2D-expressing myeloid cells, which create an immunosuppressive environment that hinders effective cancer control. Experiments in preclinical models demonstrate that genetic deletion or…
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