457-Myelin-Reactive B Cells to Drive Demyelination

Paper Talk · Jan 31, 2026 · 17m

This research explores how B cells contribute to the development of multiple sclerosis (MS) by interacting with the Epstein-Barr virus (EBV). The study demonstrates that B cells can capture myelin antigens and present them to T cells, a process that triggers inflammation within the central nervous system. By using mouse models, the authors show that expressing the EBV protein LMP1 allows autoreactive B cells to survive and expand rather than undergoing typical cell death. Findings also indicate that blood-brain barrier disruptions from past infections may facilitate the entry of these harmful…