761-Spatial Tumor Evolution Panorama of Ovarian Cancer

Paper Talk · Apr 8, 2026 · 20m

This study utilizes a multi-omic approach to map the spatial evolution and metastatic progression of high-grade serous ovarian cancer. By integrating whole-genome sequencing, single-cell transcriptomics, and spatial imaging, researchers developed the STARLETS framework to trace how hypoxia and immune pressure drive the selection of aggressive tumor clones. The findings highlight a unique tripartite ensemble consisting of specific macrophages, fibroblasts, and malignant cells that form spheroid structures to facilitate spreading within the abdominal cavity. Furthermore, the research identifies…