1582-The Pan-Cancer Single-Cell Multimodal Regulatory Atlas

Paper Talk · Sep 16, 2026 · 21m

This research paper introduces a pan-cancer single-cell atlas that explores the gene regulatory networks of 60 human cancer cell lines through multimodal profiling. By integrating transcriptomic and chromatin accessibility data, the authors identify a universal epithelial-mesenchymal transition (EMT) axis that exists independently of a tumor's tissue of origin. The study highlights how copy-number variations, particularly transcription factor amplifications like CEBPB, act as primary drivers for reprogramming malignant cell states. Furthermore, the authors uncover a significant regulatory…