898-Remodeling of Neuronal Membrane Periodic Skeleton

Paper Talk · May 4, 2026 · 18m

Recent research reveals that the membrane-associated periodic skeleton (MPS), a structure previously thought to be stable, undergoes continuous disassembly and reassembly in neurons. Using live-cell super-resolution imaging, scientists discovered that this skeletal network regularly remodels itself even without external triggers. This dynamic process is controlled by calcium signaling, which activates enzymes like protein kinase C and calpain to temporarily break down the actin and spectrin components. These cycles of destruction and repair are essential because they facilitate axonal…