Latest / 20-Minute Health Talk / Heart disease and pregnancy: Prevention, treatments and a new approach
Transcript
- 0:08Sandra Lindsay (Host): Hello,
- 0:08and welcome to 20 Minutes Health
- 0:11Talk. I'm sandra lindsay.
- 0:13Pregnancy is like a stress
- 0:16test on the body.
- 0:18Most women adapt just fine.
- 0:21But for some,
- 0:22the strain can dramatically
- 0:24raise the risk of heart disease,
- 0:26which continues to be the No. 1
- 0:29cause of maternal
- 0:31mortality in the US.
- 0:33Addressing the risk factors
- 0:36based on gender has become an
- 0:38important strategy to
- 0:40reduce this toll,
- 0:42which is why our guest today,
- 0:44Dr. Evelina Grayver,
- 0:47has turned her attention to a
- 0:49new field of medicine called
- 0:51cardio-obstetrics,
- 0:54which brings together a team of
- 0:56specialists in cardiology
- 0:59obstetrics and maternal fetal
- 1:01medicine to care for expecting
- 1:04mothers. Dr.
- 1:06Grayver is Director of Northwell
- 1:09Health Woman's Heart program for
- 1:11the central region and helped
- 1:14launch Northwell's Cardio
- 1:16obstetrics program in 2020.
- 1:20She joins us today to explain
- 1:22how this program came to be and
- 1:25how it is helping detect and
- 1:27prevent heart issues before,
- 1:30during, and after pregnancy.
- 1:33Here is my conversation with Dr.
- 1:35Evelina Grayver.
- 1:40All right, well,
- 1:41such a pleasure again
- 1:43to meet you,
- 1:44and thanks for joining us today
- 1:46on 20 Minutes Health Talk.
- 1:47Dr. Grayver: Thank you.
- 1:48Sandra: Earlier this year, I had Dr.
- 1:51Stacey Rosen on the podcast
- 1:53during Heart Month.
- 1:55And as you know, Dr.
- 1:56Grayver,
- 1:57she is the president of the Katz
- 1:59Institute for Women's Health
- 2:01here at Northwell.
- 2:02And one of the things that
- 2:05fascinated me that she mentioned
- 2:07and I wanted to delve
- 2:09deeper into it,
- 2:10is heart disease and pregnancy,
- 2:13right?
- 2:14How one affects the other,
- 2:16vice versa.
- 2:17Dr. Grayver: I know, it's very interesting, right?
- 2:21So we're not used to recognizing
- 2:24the fact that heart disease
- 2:25can be in women.
- 2:26We are not used to the fact that
- 2:29heart disease can affect
- 2:30the young.
- 2:31And now you're taking a
- 2:32combination of a young woman
- 2:34who's not even thinking of
- 2:35having any cardiac
- 2:36issues at all,
- 2:37who is either thinking of
- 2:40getting pregnant or is pregnant
- 2:41and develops cardiac
- 2:42complications.
- 2:44Pregnancy really is like a
- 2:45stress test on the body,
- 2:47on a woman's body,
- 2:48based upon all of the
- 2:48hemodynamics that take place,
- 2:51your heart rate significantly
- 2:52increases because of the
- 2:54fact that your heart,
- 2:55it goes from pumping usually
- 2:57four to five liters of
- 2:58blood per minute.
- 3:00To about eight to ten liters
- 3:02of blood per minute.
- 3:03So that's a significant strain
- 3:05on the heart, right?
- 3:06So in med school we were taught
- 3:09a lot of really sort of clear
- 3:11cut evaluation in reference to a
- 3:14woman that does have congenital
- 3:16heart disease and gets to the
- 3:17point where she's in her
- 3:18reproductive years and wants
- 3:19to become a mom.
- 3:20And subsequently we know the
- 3:23fact that there is a potential
- 3:24risk of maintaining a pregnancy
- 3:27with certain of that congenital
- 3:28component. However,
- 3:30the one thing so we kind of knew
- 3:31it as a sort of a one way
- 3:33street relationship,
- 3:34but we never understood the fact
- 3:35that that it's actually a
- 3:36two way relationship.
- 3:38Meaning because of that
- 3:39component of a stress on the
- 3:41body and on the heart during the
- 3:42time of the pregnancy a lot of
- 3:44women develop what's called
- 3:45adverse pregnancy outcomes.
- 3:47And adverse pregnancy outcomes
- 3:49are known as sort
- 3:51of preclampsia,
- 3:53which is high blood pressure
- 3:54during the time of the actual
- 3:56delivery and other complications
- 3:58of it,
- 4:00or spontaneous preterm delivery
- 4:02before the week of 32 or
- 4:04intrauterine growth restriction
- 4:06where the baby's a little is
- 4:07definitely smaller than
- 4:08its expected size.
- 4:09The old school mentality
- 4:11was that it happens,
- 4:13the woman delivers,
- 4:14the baby's good,
- 4:15the mom is good.
- 4:16We maintain the blood pressure
- 4:17well controlled within
- 4:18the first week or so,
- 4:19and then it's forgotten.
- 4:21We now know that that's
- 4:22not the case.
- 4:23We now know the fact that those
- 4:24women that have those adverse
- 4:26pregnancy outcomes
- 4:27the preclampset,
- 4:28the spontaneous preterm
- 4:29delivery,
- 4:29the intrauterine growth
- 4:31restriction,
- 4:32they are at significant risk for
- 4:34lifelong cardiovascular disease.
- 4:37So,
- 4:37whereas we know the fact that
- 4:39there are certain classical
- 4:40risk factors right,
- 4:41there's the diabetes,
- 4:42there's the hypertension,
- 4:43which is the high blood
- 4:44pressure, high cholesterol,
- 4:46smoking,
- 4:46obesity we know those are sort
- 4:48of the classic risk factors
- 4:50for the heart.
- 4:51But now these adverse pregnancy
- 4:53outcomes have finally made it
- 4:55into what's called novel gender
- 4:57specific cardiovascular risk
- 4:59factors where we know the fact
- 5:01that these women have to be
- 5:03clearly monitored very closely
- 5:05during the first six to twelve
- 5:07months after delivery because
- 5:08that's when we see the
- 5:10most complications.
- 5:11That's when we see certain
- 5:12heart attacks,
- 5:12that's when we see strokes for
- 5:14those a lot of those
- 5:14young women.
- 5:16Sandra: So really, who is at risk?
- 5:20Dr. Grayver: Everyone.
- 5:22There are certain women that
- 5:24are at higher risk.
- 5:26Certain races,
- 5:27such as African American women,
- 5:29such as women of Hispanic
- 5:31descent,
- 5:31they are at higher risk.
- 5:33Women that have predisposing
- 5:35conditions such as baseline
- 5:37hypertension, baseline diabetes,
- 5:40those that have other risk
- 5:41factors that I mentioned that
- 5:42are considered classic
- 5:43risk factors.
- 5:44So obviously those women that
- 5:45are going into the pregnancy
- 5:48with those risk factors are at
- 5:49higher risk of developing the
- 5:51adverse pregnancy outcomes.
- 5:53And we see a lot more of them
- 5:55now because a lot of women tend
- 5:57to get pregnant a little
- 5:58bit later in life.
- 6:00Women prioritize career at
- 6:02a certain period of time.
- 6:03But even those that do not,
- 6:05even the younger ones that are
- 6:06in their early 20s, mid 20s,
- 6:09are still at risk,
- 6:10and we don't know why.
- 6:12And this is where the research
- 6:13in the field is so,
- 6:14so important at this
- 6:15period of time,
- 6:16because we don't know
- 6:17what happens.
- 6:17Is it the fact that what comes
- 6:20first is the chicken or the egg,
- 6:21as they say? Right.
- 6:22So is it the fact that
- 6:23the pregnancy,
- 6:24because of it being sort of like
- 6:26a stress test on the body,
- 6:27unveils certain things?
- 6:29Or is it that the... placenta
- 6:34releases something and there's
- 6:36issues with the actual
- 6:37vasculature of the placenta that
- 6:39increases the woman's risk?
- 6:40This is where the research is.
- 6:42This is why this is such a
- 6:44highly rapidly developing
- 6:46field right now,
- 6:47because we don't know enough
- 6:49and we need the research.
- 6:51Sandra: And Dr. Rosen shared that as well,
- 6:54just in women and heart
- 6:56disease in general,
- 6:57she kept stressing the
- 6:59importance of research.
- 7:02And it's kind of scary because
- 7:05up to six months after delivery,
- 7:07you mentioned and oftentimes
- 7:10women believe that you deliver
- 7:13and you're good.
- 7:14And a lot of the symptoms that
- 7:16you mentioned could be justified
- 7:20by other things, right? Yes.
- 7:21Dr. Grayver: 100%. Yes.
- 7:22Sandra: Shortness of breath or
- 7:23feeling fatigued.
- 7:24You just have a new baby and
- 7:26you're not sleeping.
- 7:27So I would say perhaps women
- 7:30would delay coming into the
- 7:32hospital because they think
- 7:33these symptoms are related to other things.
- 7:36Dr. Grayver: Very much so.
- 7:36And to be honest with you,
- 7:37a lot of it is very cultural,
- 7:39and there's a little bit
- 7:39of a bias right.
- 7:41Even before delivering during
- 7:43the time of the pregnancy,
- 7:45for some reason,
- 7:46it appears that when
- 7:48a woman is pregnant,
- 7:50being short of breath
- 7:51has become a normal.
- 7:53Having significantly swollen
- 7:55feet is a norm.
- 7:57And when they come to me with
- 8:00those swollen feet and the
- 8:02swollen hands and the
- 8:03significant shortness of breath,
- 8:05I always tell them we have
- 8:06to rule out all other
- 8:08possibilities,
- 8:09including cardiomyopathies,
- 8:11including gestational
- 8:12hypertension,
- 8:13including everything else that
- 8:14can actually fall into before
- 8:16we actually say that this is
- 8:18pregnancy related. Right.
- 8:19And unfortunately,
- 8:21I do end up catching anywhere
- 8:22between five to 10% of those
- 8:25women that do come in with
- 8:27pregnancy normal short of breath
- 8:29that's actually just not
- 8:30pregnancy induced.
- 8:31Sandra: So I just want to clarify
- 8:33for our listeners yes.
- 8:34Swollen hands,
- 8:35swollen feet, shortness of
- 8:37breath, when you're pregnant,
- 8:39it's not a pregnancy symptom that you should be comfortable with.
- 8:46Dr. Grayver: Correct. Correct. Again,
- 8:49there are certain normals that
- 8:50come across. However,
- 8:52those symptoms have
- 8:54to be evaluated,
- 8:55and it's not even to be stricken
- 8:58panic of any kind.
- 9:00But to be able to see
- 9:01a cardiologist,
- 9:02to get a baseline EKG,
- 9:04to get a baseline echocardiogram
- 9:06and an ultrasound of your heart
- 9:08to assess to make sure the fact
- 9:09that you don't have any
- 9:10significant cardiomyopathy or
- 9:12weakening in the heart muscle
- 9:13or vavillar disease.
- 9:15Because unfortunately,
- 9:16one of the things that pregnancy
- 9:18does unveil as well is
- 9:20vavillar disease.
- 9:21Disease of the valves that
- 9:24potentially young woman would
- 9:25never really know about because
- 9:27they may not have seen a
- 9:28physician besides maybe their
- 9:31pediatrician or something
- 9:32of that nature.
- 9:32And maybe someone sometime
- 9:34mentioned that they might have
- 9:35had a murmur but they didn't
- 9:37pay attention much to it.
- 9:38So once again,
- 9:40exactly like you said,
- 9:41delaying care and thinking the
- 9:43fact that certain symptoms such
- 9:45as the shortness of breath,
- 9:46such as the swollen hands and
- 9:48feet and face is considered
- 9:50to be normal pregnancy.
- 9:52It's not normal pregnancy until
- 9:54you've ruled out all the other
- 9:56possibilities. Yes,
- 9:57Sandra: I served as the Director of
- 9:59Critical Care at Long Island
- 10:01Jewish Medical Center recently
- 10:03and I remember seeing women
- 10:05postpartum coming in with
- 10:08cardiomyopathy just
- 10:10out of nowhere.
- 10:12Dr. Grayver: So peripartum cardiomyopathy
- 10:14it's actually very interesting
- 10:15that you say that.
- 10:16I actually am rounding this week
- 10:19in the CCU at North Shore and I
- 10:21actually have a postpartum woman
- 10:23there with a significant
- 10:25complication with peripartum
- 10:27cardiomyopathy.
- 10:28So peripartum cardiomyopathy or
- 10:30the weakening of the heart
- 10:31muscle can take place anywhere
- 10:33between two to four weeks before
- 10:36the delivery and even up to six
- 10:38months after the delivery.
- 10:39It's one of those things
- 10:41that is kind of 30 30,
- 10:4330% stay the same,
- 10:4430% actually unfortunately get
- 10:46weaker and 30% do get better.
- 10:50We need to monitor those women
- 10:51incredibly closely like you
- 10:53mentioned in the cardiac
- 10:54intensive care unit to make sure
- 10:56the fact that they don't
- 10:56decompensate to get them on the
- 10:58appropriate medical therapy.
- 10:59But it's sometimes very hard,
- 11:01right?
- 11:01Because you have a young mom who
- 11:05just gave birth or is about to
- 11:07give birth and she's in the
- 11:10height of her happiness
- 11:11as they say.
- 11:12She's about to become a mom and
- 11:13she's going to have a lot of
- 11:14responsibility on her hands.
- 11:16And this is where a lot of women
- 11:17get into trouble because of they
- 11:20will prioritize that baby.
- 11:22Right.
- 11:23And unfortunately they will not
- 11:25prioritize themselves and all of their ailments.
- 11:30Sandra: So we know, Dr. Grayver,
- 11:30that about 80% of cardiac
- 11:33disease is preventable.
- 11:35How can we prevent heart related
- 11:38problems during pregnancy?
- 11:40Dr. Grayver: So the first thing is to make
- 11:42sure that you are in the best
- 11:44cardiovascular shape before
- 11:46getting pregnant.
- 11:47Sandra: And how do we do that?
- 11:48Dr. Grayver: That is with constant
- 11:52I don't like to say diet because
- 11:54people think when people die
- 11:56it's like a two to four
- 11:57week sentence.
- 12:00I'm talking about more of a
- 12:01lifestyle modification and being
- 12:03able to maintain a healthy diet,
- 12:06which you and I can discuss for
- 12:07hours as to what that
- 12:08actually means.
- 12:09And continuous exercise where
- 12:11you're exercising at least
- 12:1330 minutes a day,
- 12:14at least five days out
- 12:15of the week, okay.
- 12:16And maintaining your ideal
- 12:18weight. That's number one.
- 12:19I think the other component is
- 12:21never be concerned about getting
- 12:25what's called preconception
- 12:26counseling. Okay?
- 12:27Meaning if someone ever told you
- 12:29the fact that there is a genetic
- 12:32predisposition for heart
- 12:33disease in your family,
- 12:34if somebody has ever told you
- 12:36the fact that maybe you did have
- 12:37an abnormal EKG or an abnormal
- 12:40physical exam consistent with a
- 12:41murmur before getting pregnant,
- 12:43go see a cardiologist.
- 12:45I think that's also quite
- 12:46important to do.
- 12:47We want to make sure the fact
- 12:48that all of those classic risk
- 12:50factors that we spoke about
- 12:51for heart disease,
- 12:52such as the diabetes,
- 12:53the cholesterol,
- 12:54the hypertension, the smoking,
- 12:55the obesity,
- 12:56all of it is controlled,
- 12:57that you don't smoke or vape
- 12:59because vaping right now is even
- 13:01more prevalent within the
- 13:02young than smoking.
- 13:04And then if you do have genetic
- 13:06predisposition,
- 13:07because that's the other 20%,
- 13:09right? So 80% is preventable.
- 13:1020% is genetic.
- 13:12And we cannot run away
- 13:13from our genetics.
- 13:14We cannot run away from our age,
- 13:16even though I try every day.
- 13:17[Laughter]
- 13:20And we cannot run away from sort
- 13:22of our genetic cultural
- 13:24background. Right,
- 13:26but if you know that,
- 13:27if you know that,
- 13:28then getting that early
- 13:30preventative evaluation is key.
- 13:33So there's a lot of women
- 13:35that come to see me with
- 13:37preconception counseling,
- 13:38women that have congenital
- 13:41disease,
- 13:42that are on certain medications
- 13:43that are not,
- 13:45as I like to call them,
- 13:46pregnancy friendly.
- 13:48So we do have to change the
- 13:50management in reference to those
- 13:52medications that are more
- 13:55consistent with medications that
- 13:57are safe for both the
- 13:58mom and the baby.
- 13:59And thank God we have plenty of
- 14:01options at this period of time
- 14:03for those women that actually
- 14:04develop any of one of those
- 14:05adverse pregnancy outcomes such
- 14:07as preclamshare or anything
- 14:08else. We have options that are,
- 14:11again,
- 14:11safe for the mommy and safe for
- 14:13the baby during the time of the
- 14:14pregnancy and then during the
- 14:15time of lactation breastfeeding
- 14:18that are safe for both.
- 14:20Sandra: I'm sure you'd love to see the
- 14:22preconception numbers go up
- 14:25significantly for people to come
- 14:27in before they actually
- 14:29run into trouble.
- 14:32Dr. Grayver: Yes. Yes. And it's interesting because the
- 14:34one thing that I learned in
- 14:35this program, I myself,
- 14:37is that once a woman makes it
- 14:39a goal to get pregnant,
- 14:41god help anyone that
- 14:42stands in Hawaii.
- 14:45But the key really is to
- 14:48understand the fact that
- 14:50pregnancy is really not as
- 14:51glamorous as some of the
- 14:52magazines make it and women
- 14:55can get in trouble.
- 14:56And women do develop symptoms
- 14:58that they completely brush off.
- 15:00Off. So yes,
- 15:01I would love to see those
- 15:03preconception numbers to go
- 15:04significantly up higher.
- 15:06Sandra: Awesome.
- 15:06So we have here at Northwell a
- 15:10cardio obstetrics program.
- 15:12Dr. Grayver: Yes
- 15:12Sandra: Can you tell us a little bit
- 15:14more about that?
- 15:15Dr. Grayver: So, Cardio-Obstetrics program.
- 15:16And I know it's going
- 15:16to sound funny,
- 15:17but that really is kind
- 15:18of my baby, really.
- 15:21Yes.
- 15:22The point of the program is for
- 15:24there to a seamless efficient
- 15:27way that OBGYN can immediately
- 15:31refer their patients post
- 15:34delivery with preclampsia or
- 15:36any other adverse pregnancy
- 15:38outcomes,
- 15:39or if those OBGYN feel that
- 15:43their patient actually needs to
- 15:45have preconception counseling
- 15:47because of the fact that they've
- 15:48had either cardiac surgery in
- 15:50the past as a child because they
- 15:51were born with congenital heart
- 15:52disease or developed something
- 15:54within their teenage years or
- 15:55their early twenty s and
- 15:56they need to be seen.
- 15:57So that is sort of a very
- 15:59seamless efficient way for
- 16:01patients to kind of cross over
- 16:03easily without OBGYN having to
- 16:05scramble which cardiologists
- 16:06they're going to see or not.
- 16:08And the other component of it is
- 16:09the fact that we have now chosen
- 16:12cardiologists that sort of
- 16:15became experts in the field,
- 16:17meaning that they've shown
- 16:18so much interest in it.
- 16:19They've done extra legwork,
- 16:22really to kind of understand the
- 16:25pathology pathophysiology as to
- 16:27what happens during the
- 16:28time of the pregnancy.
- 16:29How do certain drugs
- 16:30affect that?
- 16:31We've created a certain group of
- 16:33cardiologists and a certain
- 16:34group of OBGYN that really have
- 16:37that seamless transaction
- 16:38between their patients.
- 16:39It's a very,
- 16:40very unique program.
- 16:42It's one of the few
- 16:43in the nation,
- 16:44but one of the most
- 16:46rapidly growing.
- 16:47Sandra: When did the program begin,
- 16:49the Cardio Obstetrics program
- 16:51and what are your goals
- 16:53for the program?
- 16:55Dr. Grayver: So Cardio Obsess program
- 16:57officially started
- 16:58in September of 2020.
- 17:08Sandra: So was that after which wave?
- 17:11Dr. Grayver: It was after one of the
- 17:12original waves.
- 17:13So what happened was that my
- 17:16interest in Women's Heart
- 17:17program started to grow
- 17:20early on in my fellowship.
- 17:22And that's when Dr.
- 17:23Rosen took me on as a mentee.
- 17:27And I realized and subsequently
- 17:30when I was in charge of the
- 17:31cardiac intensive care unit,
- 17:33the CCU,
- 17:34there were too many women in my
- 17:36unit that did not carry the
- 17:38typical risk factors that I
- 17:39was taught in regarding to
- 17:40cardiovascular disease.
- 17:41And that's where Dr.
- 17:42Rosen and I started really
- 17:43thinking about the importance of
- 17:45the woman's heart program.
- 17:47And after the original wave of
- 17:51COVID when I served and
- 17:54ran the COVID unit,
- 17:56I came out of the COVID land
- 17:58realizing the fact that
- 17:59I really wanted to do.
- 18:00Do something more for longevity.
- 18:04And that's where Cardio
- 18:05B was born.
- 18:06It's for the entire
- 18:07health system.
- 18:07I'm in charge of the
- 18:08central region,
- 18:09which is the North Shore LHI and
- 18:10Catswoman's Institute on the
- 18:12east end. We have Dr.
- 18:14Kashibato and Dr.
- 18:16Eugenia Gianos on
- 18:18the western end.
- 18:19And it's a full thickness
- 18:20program,
- 18:21meaning the fact that we're not
- 18:22only seeing patients
- 18:23as an outpatient,
- 18:24but we all also see inpatient
- 18:26consultations as well when those
- 18:27women come in or other cardiac
- 18:29complications occur that needs
- 18:31to be urgently evaluated and
- 18:33potentially even monitored at
- 18:35the cardiac intensive care unit.
- 18:37And I want to make a difference
- 18:39in reference to, number one,
- 18:40the paternal mortality,
- 18:42which is really horrible
- 18:44in the United States.
- 18:46And since cardiovascular disease
- 18:48is the number one reason why the
- 18:51mortality of pregnant women or
- 18:54postpartum women is the highest,
- 18:57I really take it incredibly
- 18:58personally for me to make a
- 19:00little bit of amend in that
- 19:01atrocious number.
- 19:03Sandra: Wow.
- 19:04Your passion is just palpable,
- 19:06and I thank you for
- 19:07your service.
- 19:09Dr. Grayver: The one thing that has gotten me
- 19:12personally through that post
- 19:14COVID burnout is finding
- 19:17that passion,
- 19:18is finding the fact that I'm
- 19:19actually able to find something
- 19:23that I genuinely enjoy and bring
- 19:27in as much as possible of these
- 19:29women that I know if I can
- 19:33implement all of the necessary
- 19:36changes will make a monstrous
- 19:39change in their life.
- 19:41Sandra: For cardiac disease in general, women
- 19:45black women are three to four
- 19:48times more likely to develop
- 19:50cardiovascular disease than
- 19:52other ethnicities.
- 19:55Dr. Grayver: Yes
- 19:56Sandra: Is that the same for
- 19:59Dr. Grayver: Cardiobsetrics?
- 20:00Sandra: Cardio-obstetrics?
- 20:01Dr. Grayver: Yes. African American women are
- 20:04anywhere between actually 4
- 20:05to 6% higher to actually develop
- 20:08at risk pregnancy outcomes and
- 20:10preclampsia and gestational
- 20:12hypertension and gestational
- 20:13diabetes being the highest ones.
- 20:17And these are women that, again,
- 20:19did not have or did not know
- 20:21that they had any predisposing
- 20:23conditions.
- 20:24And it's not women that are at
- 20:27a higher BMI level or greater
- 20:30obesity. Not at all.
- 20:32It's a matter that, again,
- 20:34part of research that we
- 20:35definitely need to do is
- 20:37understanding the vasculature,
- 20:38the vasculature difference
- 20:39between an African American
- 20:41women and other ethnicities.
- 20:45Sandra: Very well. Well,
- 20:46this has been an interesting
- 20:47conversation. Dr. Grayver,
- 20:49thanks so much for joining me.
- 20:50Dr. Grayver: Thank you.
- 20:51It's great to be able
- 20:52to share it.
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