1460-Age-Related Lymphocyte Pathways&Mechanisms in Sepsis
This review article examines how sepsis uniquely impacts the immune systems of elderly and pediatric patients, focusing on the failure of lymphocyte subsets. While both age groups experience immunosuppression and lymphopenia, the underlying causes differ: older adults face immunosenescence and low recovery reserves, whereas children experience a derailment of their developing immune programs. The authors argue that similar clinical symptoms, such as secondary infections and persistent inflammation, actually represent distinct biological trajectories based on the patient's age. To address…
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