152-IFNγ Orchestrates Leptomeningeal Anti-Tumor Response
This paper details research into leptomeningeal metastasis (LM), a fatal complication of solid tumors in the central nervous system. The study uses multimodal analyses of human clinical specimens and immunocompetent mouse models of lung, breast, and melanoma cancers to investigate the immune response within the leptomeninges. Key findings indicate that the cytokine Interferon-gamma (IFNγ) is a critical mediator of anti-tumor activity in this anatomical space, and its presence correlates with improved patient survival. Mechanistically, T cells generate IFNγ, which acts on conventional…
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