1191-Spatially Single-Cell Atlas of Human Meningioma

Paper Talk · Jun 27, 2026 · 16m

This study utilizes spatially resolved single-cell analyses to map the complex cellular architecture of human meningioma, the most common adult brain tumor. By examining over 580,000 nuclei and millions of cells through spatial transcriptomics, the researchers identified specific transcriptional metaprograms that define both neoplastic and non-neoplastic cell states. A primary focus of the research is the tumor microenvironment, specifically how myeloid cell states evolve from the surrounding dura into the tumor and how these interactions influence tumor progression. The data reveal that…