Latest / Ageless and Timeless Podcast® / Dr. Bill Andrews, Founder and CEO of Sierra Sciences and Sierra Holdings

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Dr. Bill Andrews, Founder and CEO of Sierra Sciences and Sierra Holdings · Ageless and Timeless Podcast®

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Good morning everyone. This is Michelle Hughes from Ageless and Timeless. I have
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a wonderful guest today. I always say that, but I always have wonderful
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guests. And his name is Bill Andrews, and he's very very famous.
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If you haven't heard from him, he is a king, in my opinion
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anyway, of anti aging science and technology. And he's going to tell us
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a lot today about telemeres and aging and why we age. And so Bill,
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welcome to Ageless and Timeless. Thank you, welcome. I'm glad to
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be here. You know, Bill, there's so much about you. I
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almost don't know where to start. But you know, Lisa and I are
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very good friends, as you know Lisa Tomati, and I know you were
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on her podcast recently. I guess, and I know you too and your
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wife share something in common that is just absolutely stunning, amazing, and that
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is your long distance running. So let's start off by just telling us a
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little bit about what is it about running that has intrigued you and chanted you
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and captivated you for all these years? And what is the future going to
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be when you are trying now? I guess in your you said and you're
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going to be in your seventies and you're going to be the number one long
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distance runner. So I think that's a pretty lofty goal. But tell us
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a little bit more about you know, why running is so important to you.
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Well, you know, there's nothing that makes you feel more invincible in
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your life and knowing that you're completed one hundred mile race, you know,
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and it's like health wise, it's a good it's a good way to make
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you feel like you're doing everything right and you're healthy. But the true thing
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about ultra marathon running, it's the adventure. I mean, it's like no
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other sport. I know. If you can go out in the middle of
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the wilderness, run all day, all night, and have places where suddenly
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you come around a turn on a trail and there's a table with food and
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water for you so you can continue on, and it's it's just the adventure
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because you go places nobody else has ever gone. Yeah, I understand you
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went to that India in India, right to the peak that was created by
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someone who I think must have been a hater of people, because he gave
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me one of the most difficult challenges I think that you could ever ever do.
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Why don't you tell us a moment about that, a little bit about
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that. That race is called the Ultra to the High. It's only one
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of many races that I've done like that. It's a race in the Himalayas
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of northern India that starts at fourteen thousand feet elevation and it was okay,
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eighteen thousand feet elevation twice. Wow. The lowest point of the whole course
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is eleven thousand feet between the two peaks, and it's one hundred and thirty
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eight miles long, non stop running. Okay, So it took me fifty
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two hours, non stop, all two nights without sleeping, stuff like that
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to eat that race. But I'm I think I'm still the oldest person to
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ever finish that race. And my wife was the first American woman to ever
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finish that race, and there was only one other woman that had ever finished
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it beforehand, but she wasn't American, right, was that was that?
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Lisa? No, No, Molly Sheridan, my wife. But Lisa Comity
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ran that race too, right, and she ran it the second year that
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my wife ran it. So I've run it twice. My wife has run
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it twice. Lisa has run it once and maybe she's smarter than the rest
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of us, but both my wife and I thought that was the most fun
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experience ever. Okay, I mean we've also run through Death Valley and the
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Bad Water Race and one hundred and thirty degrees temperature and fahrenheit, and we
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thought that was fun too. It was. That was one hundred and thirty
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five miles NonStop. My wife is run through the Sahara Desert in a race
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called Love I'm going blank on the name of the race, but it's it's
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a you go through the Sahara Desert starting in Morocco, and it's a five
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day stage race. I think it's two hundred and fifty miles long. And
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she has very fond memories of that race. But it's the adventure. We're
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both addicted to the adventure of races and being an ultra marathons. You can
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do the same on bikes and things like that and KACTC. We do those
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sports too. Run for some reason gives you more an opportunity to look around
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and enjoy the scenery and carriot camera and stop and take photographs of interesting things
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even though you're in the middle of a race. I think most people oh
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I can do that playing golf. But look, I have, you know,
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so much admiration for you. I mean I have been a runner many
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many years and never never like you, never that kind of challenge. But
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I always wonder when I was running because I always used it as kind of
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a zen moment. You know, in my life, you just take to
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chill out and just use it to relax in a way, even though you
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were exerting yourself. What goes through your mind? I mean while you're running,
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what what do you think about? And how has it helped you?
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I'm asking you to questions in one but how has it helped you to be
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a healthy longevity expert? Well, let me answer that in several ways.
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One one is, let me first say that that I believe that endurance sports
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is one of the best things that anybody can do to extend their lifespan and
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health span as long as you. I mean, people will say, yeah,
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there's such a thing as too much, but running one hundred miles race
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is not too much if you are well trained and you have a philosophy that
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keep it fun. Okay, don't push yourself. So whenever I tell people
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when I speak it anti Asian conferences. You know, exercise, keep it
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fun. When it quits in fun, quit save it for another day.
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But eventually you get so good at it that you can go one hundred miles
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and still have fun. I get my se reactive protein measured all the time
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after these races, and so it's not inducing a lot of information. I
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always say that occasional running induces inflammation. Okay, one of those runners that
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run once every two weeks, you go run on marathon. You'll do well,
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but you'll be throwing up on and your hands and knees throwing up at
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the end of the race. Your inflammation levels have skyrocketing. But that ain't
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happen when you are consistent running around all the time and just enjoy yourself.
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Right. The other thing, what was the other part of your question?
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I was asking, we'll ask you what you think about while you're running?
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Is there you know? Do you have? But use it as a kind
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of a zen moment in your life. When I say moment, I'm putting
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that in quotes. Obviously it could be fifty two hours of moments. But
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what what what do you think about while you're running? Well, it's anything
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but that, Okay, I think a lot back. I just grab I
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carry a digital recorder with me when I'm running. I have a special pocket
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in my backpack on my front of the backpacket to carry this because I have
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some of the most original ideas ever while I'm running. And the problem is
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that when I get done with the race, I can't remember what they were.
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It's dreaming. It's like when you it's like when you dream at night.
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You forget you dream and then you forget your dreams, and that's so
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frustrating. I understand that, except except my thoughts are a little more logical
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than the dreams are. So I will record sometimes one hundred messages on this
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thing to myself, yeah race, and then when I get done, I'll
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listen to them, and they are brilliant, you know. It's like and
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I'm you know, it's I started this in like nineteen ninety eight, nineteen
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ninety seven. I was in a race in nineteen ninety seven and we had
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a big problem with work that I had to resolve, and I had I
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came up with a solution while I was running, so I thought, oh
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my god, I won't remember this. I came into an AID station and
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yelled, as anybody out a cell phone, mhm, somebody did, and
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I called my work, left myself a voicemail message, and then right after
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that I decided to buy it Divisital recorder to carry you because I knew i'd
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forget what that was. And I did forget what it was and had to
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go to listen to that voicemail and know what it was. And it really
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made a big difference in the company I was working for at the time.
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Was that what was it called her on the Garon Corporation. Yeah, in
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fact it was it was I had an idea of how how to clone the
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Lawry chain, which I'll explain later in more details, and that ended up
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being the way that we ended up getting it cloned. I just had to
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remind myself when I got back to work. So so it's just from a
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scientific extamp and what do you think is happening that's create that possibility that you
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have these amazing enlightenment enlightening ideas while you are running. Just try to give
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us a little the logical side of that. Today's podcast is brought to you
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you order, please use the Ageless code for a fifteen percent discount. Well,
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I think you clear your mind, okay. Nature is the best way
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to clear your mind. And when you start to think of sorry, I've
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been in a lot of conference, it's like and all of a sudden,
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your mind starts drifting to work all by itself out some problems and you're much
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clear minded. When you force your yourself to try to solve a problem.
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It's really hard to do it. But when you just naturally do it.
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The idea is just pop in your head, and that's something that things.
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I just that's why I never go without the digital recorder. It's like you
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can't just amazing the number of great ideas that pop in my head. And
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I'm sorry to interrupt, you know. I hear people saying that when they
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meditate too, that they have they've quieted their mind and it allows innovation or
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creative ideas to enter that might be clouded by the typical thinking, which you
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know is oftentimes has negativity in it or just obstacles to you know, to
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just uh, basically creating new ideas. I mean, I wonder if Thomas
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Edison or Albert Einstein, what they did, you know, when they had
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their moments like you have when you're running, how did they create out those
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uh that that enlightenment, those awareness, that awareness aha moments. Well,
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I do call it moving meditation, Okay, I don't think. I don't
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call it zen. I kind of think of xen as a little bit different
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than just basic meditation because sometimes, like I've I've I've spoken, I've been
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a keynote speaker, actually had many meditation and yoga conferences and things like that.
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So I know a lot about that, but I try to say that
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you don't have to be preaching, repeating a keyword or something like that.
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You don't have to be chanting or anything like that. You go into meditation.
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Meditation is something that you can just go into naturally, and that's when
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you get your most thinking. But when I go to some of these sessions
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and people are playing some like gentle music and recommending a chanting, I never
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have great ideas. The way I do when I'm running, it is the
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meditation moving back. You know, your endorphins to the limit. When you're
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doing that kind of long distance running, you are stimulating all those neurotransmitters that
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are allowing you to feel good. So when you feel good and everything looks
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bright and nature does tend to support as long as it's not one hundred and
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thirteen degrees might be a little bit of a test, but you know,
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when you're doing those beautiful nature runs, you are getting all the optimum stimulants
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for creative thinking. Well, I just I just want you to know that
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you know, everybody that meets you and hears about you is in awe of
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you. So there are not too many people that could claim these kinds of
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accomplishments, and and kudos to your wife, Molly, and and of course
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I've always told Lisa you know how much I admire her as well. So
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let's let's let's move on, because I want people to know a little bit
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more about you and the work you do and how you're contributing to the longevity
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movement. So, first of all, CR Sciences is the company you founded.
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Why don't you just explain to us what is your mission? And I
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know you have a foundation as well, so if you want to couple that
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with the answer, that's fine, but just tell us what what is it
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you are trying to accomplish at CR Sciences. Well, I don't have a
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foundation. I thought it, I thought it said online and I even think
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in our bio of you had said zero science is slash foundations that maybe maybe
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I need to check that again. But okay, let's just talk about Sierras
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Sciences. Then. Well, it's essentially the main goal of Sero Sciences is
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to cure the aging process. And when I say cure, what I mean
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is I want to see aging get reversed in every way imaginable. I want
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to look, feel and behave like we're twenty five again. And I've been
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studying aging my entire life. I've got more degrees and things in anti aging,
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you know, all the way from statistical theory to biology, to chemistry
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to physics, just you know, study of evolution is I've got a degree
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in that, just only because since I was a kid, I've been obsessed
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with when I grow up, I want to cure aging. And so what
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did I need to know to do that? And why didn't I believe in
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all the other theories that existed, all the world expert leaders, I could
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always find problems with their theories. I always say, the twos and twos
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have to add up, and they never did. And so I came up
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with the idea back in the nineteen seventies that the only well first aging is
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kind of programmed. It's not just a random event. Look at Bell curves
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or curves of the distribution curves how old people are when they die, and
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you can see that they don't fit the typical model of randomness. There is
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something programmed in all of life forms that do have an aging process. And
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so we learned that in nineteen sixty one, doctor Leonard Hayflick had showed that
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human cells dish can only divide a certain number of times and they go's essence,
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that's called the hate flip c limit. So I put all those two
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things together that I just mentioned and decided, you know, and I knew
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enough about I'd studied a lot about chemistry and stuff like that too. How
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could how could a sell know how many times it has divided and how many
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times it has left to divide? And the only answer that could be explained
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that a cell has the ability to do was something the equivalent of ride tickets
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at an amusement park. Okay, you know, you go to a kid
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goes to the amusement prouct and mother gives them ten tickets. They go on
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a ride, they have nine tickets left. They go on another ride,
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they have eight tickets left, so they can always look see how many rights
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have they been on? How many rights does they have left? Now?
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I decided there is there is a way to imagine how a cell could have
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such accounting mechanism. And but other counting mechanisms that had been propoles just made
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no sense. There was no way in a biochemical sense it could be evolved.
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But then in nineteen ninety two nineteen ninety three, I heard a guy
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named Calvin Harley speak at a conference in Like Tahoe, California, and he
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explained that telomeres, the tips of our chromosomes, shortened as we age.
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And he explained that every time a cell divides, the teal americ gets a
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little bit shorter, and not because of any mechanism. There's no mechanism that
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makes it shorter, totally due to the lack of the ability of the cell
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to replicate all the way to the very end of the chromosome. So every
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time a parent cell divides to make two daughter cells, everything in that parent
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cell first has to be duplicated or replicated so that the two daughter cells have
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the identical things. That includes the chromosomes. But it turned out that in
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fact, this was nonsense. In nineteen seventy seventies, when Alexia livn Nikov
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and Jim Watson, one of the discovers of DNA, I don't can't believe,
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I can't remember his name, but they both proposed that they both noticed
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that the cells lacked the ability when during replication, to replicate all the way
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to the very end of the chromosomes. So every time a new chromosome mate
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is made, it's shorter than the original chromosome. So there was no wear
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and tear, no degradation, no unraveling. It's just the new DNA was
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shorter because the cell lacked the ability to replicate all the way to the end.
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And so I started realizing these could be the ride tickets. Okay,
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every time the DNA replicated, the DNA is a little bit shorter, so
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it essentially didn't lose the end the other ticket. It just never got the
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ticket duplicated. So every time, so it gets shorter and shorter and shorter
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with cell divisions, and that could be an explanation for why we age.
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But the mystery was, if that was true, then our children would be
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born with shorter telomeres or shorter chromosomes than we have. Their children would be
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born with shorter chromosomes than they have, and we would have been extinct after
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just a few hundred generations and or maybe even less. So there had to
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be some way in our reproductive cells, called our primordial germ cells. There
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had to be some way in those cells to be able to replicate all the
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way to the very end. Otherwise, you know, our children would be
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born with less chromosomes. And so I when I heard this guy talk at
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in like Tahoe, I went up to him immediately and said, as anybody
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figured out a way to lengthen the telomeres the way that our reproductive cell dude,
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And he said, no, They've been working on it for years with
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collaborations all over the world. I just said, you know, let me
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come and work for you, and I have it figured out in three months.
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And I did have a track record. I'm I'm more blockbusters and biotech
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than anybody you've ever met or ever heard of human plast manage and activate and
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stuff. He knew that, so he accepted. He offered me the job
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on the spot, and three months and seventeen days later, I discovered me
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and my team that I led discovered the enzyme called to lam race I found
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in our reproductive cells that keep our reproductive cell DNAs from shortening every time.
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So that's that's how I got into it. Now. I'm not saying that
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tilomeres are the only cause of aging, but no matter what else can we
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do to solve the aging problem, we will never work unless we also solve
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the tilmor shortening problem. Well, we know that there was Tha sixty five
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and that that was being chouted as the answer to lengthening pila meres. What
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what did you think of Ta sixty five? Well, what do you think
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of it? And what else is uh? You know today in the world
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that is so cutting edge, with so much science and technology, what are
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what are the contributors to lengthening your fila meres other than the Ta sixty five.
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But let's just first focus on the Ta sty I know you were involved
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with that, right, I'm one of the inventors of th A sixty five.
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Yeah, while I was at geral In Corporation. But I'll be honest
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with you, it was so WEAKLM lengthening. Shortening is like a tugger wark.
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Okay, you can you can lengthen tilamers. You also have the other
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side of the tuggle work, shortening telomeres. The net result is still shortening.
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Okay, So think of it as people in the tuggleware. Some people
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are pulling to lengthen some people are pulling to shorten. If you have the
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same number of people on both sides, it's the tie order. But in
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all of our cells except for our primary dio jerm selves. We have nobody
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on the lengthening side, and so all we get is shortened. He said,
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we're pulling to shorten and length shortened the telomeres. So now TA sixty
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five comes along. It's the very first thing ever. It added one person
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to the side to lengthen, but there's like one hundred or more people on
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the side to shorten. So A sixty five does lengthen, but shortening is
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still occurring, and the net result is that the time is still shortened,
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but at a shorter rate. So I was my mission wasn't to create a
24:00
product to make money. That was never my goal, Michael, create a
24:03
product that was actually going to reverse aging, right, THA sixty five was
24:10
not the answer. It was two weak And I hope I don't get any
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ceased assist letters for saying that I started Sierras Sciences simply to find something a
24:26
lot stronger than TA sixty five. We have found thirty seven natural products that
24:33
are stronger than TA sixty five now, and we've found over nine hundred pharmaceutical
24:38
products. I don't not products, but ingredients, ingredients, chemicals. We've
24:44
found nine hundred plus chemicals that are much stronger than Tha sixty five, and
24:48
I'm talking about thousand folds stronger. But you know, we're still looking for
24:53
people at a market because we're not a marketing company. All we do is
24:59
we haven't found something it's potent enough yet to stop the aging process. Calculate
25:07
that our strongest chemical chemicals are far stronger than nutriceuticals, right, But I
25:15
hope we can find a nutraceutical that's strong too, because then fta approval and
25:19
you're taking something natural but are strong. The strongest pharmaceutical it's called zero three
25:26
one four eight one eight. I don't got to write this down hold on
25:29
one second zero four or three one four three one four? Yeah. Why
25:37
is to have so many numbers and not a name? Well, because we're
25:42
we're doing research and we have that's our three hundred and eighteen thousand, four
25:48
hundred and three hundred and fifteen and eighteenth chemical that we tested. So we're
25:55
not going to give all of our names, right right, Well, we
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did have side of text Bill. Well, we're at the basic research level.
26:03
We're just looking first. I've done a lot of drug development. The
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first thing you do is you find a rug that has activity, then you
26:11
do medicinal chemistry to get rid of side effects. Now this is when we
26:15
have any side effects. But we did license it to a few companies and
26:21
they do have it in their products now. And they did change the name
26:25
because they didn't like the long number. It changed AM eight one eight,
26:30
and so people can find TAM eight one eight by doing Google. Soarsh,
26:33
I'm not going to promote companies. Oh yeah, yeah, We're not here
26:37
to do that. I just we just want information. So okay, let's
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go to the p newtraceutical side. Let me finish with that, because it's
26:45
still it's not potent enough to reverse aging, but it's only sixfold lower and
26:51
longer activity than what we think we need, and so we're so my focus
26:55
is to continue research to find something that's at least sixfold stronger than caesaro three
27:00
and four. Okay, and then when we have that, then we expect
27:04
then we can start asking testing the question, asking the question does that reverse
27:08
aging? This is so fascinating. Okay, So, but people who want
27:15
to jump in right now without the time is going to take for the for
27:18
you to develop the chemical side. What what what nutraceuticals can people add to
27:26
their regimen that are going to help them to lengthen their tilomeres. Well,
27:36
there's a lot of nutraceuticals that will decrease that will protect the tilomeres from what
27:41
I call accelerated shortly. Okay, there isn't any nutraceuticals on the market besides
27:48
TA sixty five that will lengthen them. But there is something coming very soon
27:56
that we've discovered and I don't want to mark but this The company name is
28:02
Touchdown Essentials. They will be UH marketing UH a new nutraceutical that is way
28:11
stronger than t A sixty five mm. It's right now. It's in UH
28:18
large scale preparation. It's going through UH pesticide testing, UH have a metal
28:27
testing and UH as soon as it passes those tests, it will be starting
28:33
to manufacture into capsules and bottles and it will become available and I'm hoping that's
28:40
within the next few months. And so what is it about it that makes
28:44
it unique to to get you know, help to not shorten tells, Well,
28:51
it induces. So it induces TOLA rise to level a lot more than
28:57
six, but not as much as the pharmaceuticals that we have. But lengthening.
29:06
Decrease in the rate of tilmer short is going to extend your lifespan and
29:10
health span either way, even if it doesn't reversure aging, we won't see
29:14
age reversal, and maybe we won't ever say, but I'm hoping. I
29:18
think it'd be very unlikely that we didn't. I'm expecting that we'll see age
29:23
reversal when we find a nutraceutical or pharmaceuticals that's six times more potent than the
29:30
one, the best one we have right now, and we think that'll take
29:33
one to three more years of research to find. And what about a stragg
29:37
lists and some of the you know, the more well known nutrients that I
29:44
mean, yeah, nutriceuticals that are on the market today. What do you
29:49
think of those in the formulas that exist today? But THA sixty five is
29:56
isolated from a Straggles's route. And but we've never we've never been able to
30:02
detect any activity at all promise tracts or any parts of the planet, and
30:07
we and any other things, the only we we do, we're I would
30:12
say my lab is probably the best in the world for actually detecting to lame
30:17
race inducing activity mm hmm. To a sixty five is uh we, but
30:23
it's it's the only UH Well. There was some other nutriscuticals that got discontinued
30:30
because of UH problems with the company itself, not not the product. Those
30:37
those those weren't those those weren't as strong as what the new one would be.
30:41
But right now, at the moment, UH the A sixty five is
30:48
the best nutricitive you could take. But I don't expect very much results.
30:53
I think most of the results are placeable effects. But this new product that's
30:57
coming out well put through touchdown essentials should be a lot more potent and should
31:07
see some benefits. And there's a phenomena that's been discovered that even with low
31:14
levels of telomeras, the shortest tilomrs do get lengthened, even though the longer
31:19
tilamres still get shorter. At lengthening of the critically short telomeres actually does provide
31:26
some age reversal events. So people can see vision getting better, they can
31:32
see hair color coming back, they can see getting better. And we've seen
31:37
that from some of the other nutriceuticals that were on the market that are weaker
31:41
than the new one's coming out. Mm hm, So I told you when
31:48
we spoke before that I had done the spectra cell test and you were not
31:53
that thrill with that measurely that that particular modality. But is there a lab
32:00
that really does get accurate readings and and is that available to the consumer that
32:07
I'm sure our viewers want to know. Well, yeah, PCR is the
32:14
method that UH spectro cell uses to measure temer length. And PCR is very
32:22
very easy to manipulate and they can without without knowing, without knowing being but
32:29
like just the SLT concentrations, the temperatures, everything like that can have a
32:32
big effect. So PCR is very very inconsistent. I don't recommend that.
32:38
What I do recommend is something called in situ hybridization I n S I t
32:45
U hybridization. And the best company for doing that, I said, I
32:52
wasn't going to market product. It's a company called Life Length in Spain.
32:57
Right. They actually they do two things. They measure the average deal in
33:02
length and they also measure the percent of telomeres that are short, because the
33:07
percent of TEMs that are short actually play a bigger role in decline of health
33:14
than the average tilament like does. So people people can it's more expensive,
33:21
but it's it's you're going to get an answer that means something. It's people
33:25
can get their telomeres measured before doing any type of treatment or taking a supplement
33:32
or and then measure it again afterwards, like six months to a year afterwards.
33:37
Do that their shortest tealing mars got longer, still got shorter. That's
33:44
a good thing. Yeah, yeah, so okay, So in addition to
33:47
the telomeres, but when you look at the you know, the kind of
33:53
macro picture of aging, what are the other areas of that picture? I
33:59
know DNA methylation is another big one for you, But why don't you tell
34:02
us more about you know, just let's just take that macro and then get
34:07
down into the micro. Like you know, the hub of a wheel is
34:09
the macro, that's the anti aging or longevity focus. And then on the
34:15
spokes of the wheel, what are some of the other influences that you you
34:19
are you know, passionate about researching to solve the problem or the disease of
34:25
aging. Well, the many other causes of aging are oxidative stress and inflammation.
34:34
Yes, finding ways to decrease those are very important. I'll come back
34:37
to that in a minute. Yeah, but stress, oxidative stress, UH,
34:46
psychological stress, all those things can can accelerate the rate of Teler short
34:52
so minimizing those is very important. And then inflammation is probably the number one
35:00
cause of aging, and every time you do something that causes inflammation in your
35:05
body, you're accelerating your aging. And so leading to a lifestyle that decreases
35:12
those is really important. Now I've done a little bit of research in those
35:16
areas, but most of what I've done is read other studies and what I
35:22
do. What I do is call critical meta analysis. Pure. I don't
35:27
just look at the titles and look at the conclusions. I read the studies,
35:30
make certain that they are legitimate. And then when I find, like
35:36
several studies on the same subject that are all legitimate, I look to see
35:39
which which one has one answer and one has another answer. Which one gives
35:45
the answer be the most and answer A the least. It turns out when
35:50
I whenever I do my critical meta analysis, all the final papers have the
35:54
same answer. But there's and I would say, DNA methylation it's really not
36:02
a cause of aging. It's a measure of asient. It's we've been able
36:08
to find in other labs that they don't find it. Lengthening the shortening telomeres
36:12
will will actually affect the methylation process, so that methylation might be the result
36:17
of tim length. And same with many other markers too of aging. They
36:24
seem to be back and forth by just changing the link to telers. Now,
36:30
we haven't been able to do lengthen and shorten telomeres and humans yet,
36:35
but we can. We've been able to do it in human cells and a
36:37
petri dish. We've been able to do it with human skin going on the
36:39
back of the mouse, and we've been able to do it with engineered mice.
36:44
Now, mice don't age by short Mice age by oxidative stress and what's
36:49
called mitochondria dysfunction Asian and uh but uh. A doctor Ron Depennell at Harvard
36:58
was able to engine near mice to make it so they do age by telam
37:02
the shorting MH and so he was able to show that lengthen and shortly did
37:09
have what he called remarkable reversal of the aging process. By Diane Sawyer back
37:16
in twenty ten showing data on that. So let's take those those oxidative stress
37:28
and inflammation and feel and ears, right, those three and what what else
37:36
is there? Is there anything other than that those three? I mean just
37:42
well, they they all kind of are related. But there's accumulation of junk,
37:49
which is a theory on aging. There's a just I'm just kind of
37:57
blank. There's like twelve hallmarks of aging right now. Most of them are
38:01
are related to wear and tear. So when I when I talk about how
38:07
we age, I always say that the first thing of aging is wear and
38:12
tear. Mm hmm. But I say that wear and tear and so oxidative
38:17
stress information, all those things calls wear in terror. The The thing about
38:23
wear and tear is that it really shouldn't cause us to age because when we
38:30
have worn and torn cells on the surface of like oregans and tissues, and
38:37
they get they die and get lost. We have other cells that can divide
38:43
to replace those sets. So like like, for instance, when when somebody
38:47
is young and let's say they have the muscular distriphy gene A good example.
38:53
I need other examples too. Let's say somebody has muscular distrophe. They have
38:58
the gene for it, but they don't they're totally unaware of it when they're
39:01
young because the dystriph and gene which is causes muscular dystrophe. Muscle cells and
39:08
so other cells have to divide faster, more often to replace those dead cells.
39:15
But as a result, the tileomeres get shorter because every time a cell
39:19
divice, that telomeres get shorter. When a person is like in their thirties
39:23
or forties, the muscle cells that are divided to replace the dead cells have
39:30
now got tilomeres that are really short and can no longer divide, and that's
39:36
when muscular dystrophy takes over and kills you, and so you essentially it's an
39:40
age related disease, die of old age at a much younger age because of
39:47
the fact that tileomeres got shorter. Another example, let me just use one
39:51
more example that I think people can relate to. More. Alcohol kills liver
39:55
cells. M hm. You can drink all you want when you're young,
40:00
because it kills the liver cells, but other cells divide to replace those cells.
40:06
You can constantly be doing this, but because of the hatflick limit I
40:10
mentioned before, our cells can't divide forever to replace those lost cells, and
40:16
so when you're in your forties something like that, you suddenly can't replace those
40:22
damaged cells anymore, and you get livers urosis and end up dying from it
40:28
oftentimes. So it's bottom line comes down. And there's a lot of causes
40:34
of aging that cause wear and tear, but most of the them will probably
40:39
end up being irrelevant as soon as we figure out a way to solve the
40:44
telum a shortening problem, because the true villain in all this is our lack
40:50
of ability for our cells to divide and definitely a certain number of times,
40:57
and so if we could prevent that from happening, who knows how long we
41:01
could live. We could live healthy for hundreds of years, just because our
41:07
bodies have the ability to replace every damage cell. MH. So Bradfast,
41:15
which you are on the board of, and I just had James Stroll,
41:19
the co founder, on my podcast last week. Obviously, the you know,
41:24
the mission and goal of Bradfast is exactly what you just said, is
41:28
to find the answers to solve the aging, for the replication of those cells,
41:35
and to basically cause the cessation of aging and create immortality. How how
41:42
do you feel about that vision as something that's achievable? Oh? Well,
41:49
very much. So let me say Jim and I have been colleagues for many,
41:53
many years, and we were doing a hike in Scottsdale, Arizona,
41:59
when we came up with the idea of creating a conference that it's exactly like
42:06
RedFest. I think it was actually Jim's idea, but I just was all
42:08
all on it right away. And we didn't want it to be like a
42:14
lot of other conferences that end up being a showcase for all the Charlatans and
42:21
just are trying to sell anything they think then why so we decided, let's
42:29
start a conference where you know, every speaker has to be qualified to be
42:35
not as Charlottean or quack. And actually, so I'm on the board of
42:37
that, and my one of my main jobs is to screen all the speakers
42:43
to make certain that they aren't somebody who's going to be trying to lie or
42:49
fake something. And unfortunately a few have gotten through and they've never been invited
42:52
back to speak. So really, I'm going to go years so I'll get
42:58
to meet you in person. And what is it when you lecture? What
43:02
are the favorite topics that you discuss not only at Radvest, but just you
43:08
know, because you give so many lectures. Is there one lecture that you
43:12
just absolutely love to give because it has so much information that you're passionate about.
43:21
Well, it depends on how much time I have, but when I
43:23
talk. But here's the bottom line is that there's a lot of a lot
43:30
of misunderstanding about what's going on in the aging process, and most people in
43:37
the aging field really do not have a background in the study of aging.
43:42
Whereas I've been studying aging my entire life, all through running anti aging clubs
43:49
in high school and college and taking all the courses I could to learn everything
43:52
I could about the subject. So what I like to do is I'd like
43:57
to clear the airr in my talks and explain what's really going on. And
44:05
I explained it in such a way as I say that there's a lot of
44:08
theories on what's all about aging, but we don't need those theories because there
44:15
are absolute facts that explain everything. And so I like I do a series
44:22
of talks, okay, And so the typical the way I describe it is
44:27
I always talk about the what, why, how, and how not of
44:32
aging. I like that those are four different and I'm going to eventually when
44:37
I get some time write a book on the subject. There's no need for
44:43
theoriests. We everything about. One of the skills that I have is have
44:47
a strong backrond around and evolution on my age population genetics, which is it's
44:53
also mycre genetics, because population genetics is the subject of the how and why
45:00
of evolution, not the what and when, which is what it means.
45:06
So why did we evolve an agent? And more importantly, why did we
45:08
never evolve a way not to age? Well, there's actually good reasons for
45:13
that that it seems sometimes like I'm the only one that seems to understand.
45:17
So what I do is my talks are explaining those So what aging is,
45:22
and that simply is aging is really nothing more than the decline and failure of
45:29
multiple tissues and organs. That's all it is. Okay, a lot of
45:31
times when people start talking about what agent is, they include the how and
45:36
the why and the why we age is simply eliminating the longer lived meaning longer
45:45
lived meaning those who have already raised their young from the population, actually increases
45:51
the diversity in the population, genetic diversity, and the more genetic diversity that
45:59
you have, more likely some members of the species will survive a rapidly change
46:04
in environment. So species that eliminate the longer lived have been more successful at
46:09
surviving rapidly changing environments than that don't. That's the two minute or one minute
46:15
version. And the next is how we age, And I've already talked a
46:19
little bit about that age because we lose the ability to replace the damage.
46:27
And then how not the age is is a big subject. One is antioxidants,
46:32
anti inflammatories, safe endurance, exercise, just don't smoke, don't thee
46:40
obese. You know, I talk a lot about these subjects, do meditation,
46:45
meditation, and extremely important yoga exercise. I think already said that one
46:51
of the weird ones is pessimism. Several studies now shown that pessimistic people don't
46:57
live as long as non up people. So but then I also talk about
47:05
all those things are really just causing wear and tear, and that what we
47:08
really have to do is we have to no, none of that will ever
47:12
allow us to live longer than a live healthy longer than one hundred and twenty
47:16
five years, unless we also solve the tilam shortening problem. So that's why
47:22
my solving the tim shortening problem. But I don't believe the war is going
47:28
to be won in one battle. Okay. I believe that figuring out how
47:31
to prevent tulum shortening is going to be in how to lengthen tures is going
47:37
to be one aspect to curing agent, and maybe it'll be the only thing
47:40
we have to do. But it's not going to cure other things that cause
47:45
aging. It's not going to cure alcoholism, for instance. It's not drug
47:50
addiction we have to so there's more to do after that. But but the
47:55
other two subjects that I speak on a lot are why is aging not here
48:02
yet? Okay, since we do know so much about it? And the
48:07
bottom line is is that in academic labs, people don't have the time.
48:14
There's too busy doing teaching, writing patents, stuff like that. All the
48:19
research is done by novice graduate students who have very little experience with doing science.
48:25
So university labs is not a really a good place to get things done.
48:30
Then in the in the business world, that you pretty much rely on
48:37
investors. But investors are early interested in investing in companies, adding value to
48:44
the company and then selling it right, And so people like me that happened
48:49
to me, I'd lose all my intellectual property and stuff like that, and
48:52
if I did any more research on it, I'd be preaching somebody else's and
48:58
contract. Right, So so it's like it's I talk about that's why agent
49:05
is not cured. That's why cancer is not cured. It's because the system
49:08
for funding these kinds of research programs don't work. Even even when you do
49:13
get grants. There's there's text in grants from like NIH and NSF saying that
49:20
they have partial partial ownership of the products and can be can to control how
49:25
the products are handled and stuff. That again destroys the ability to really get
49:30
some serious research done. But so that's the one subject I spend an hour
49:37
on that. Then another subject is why do people think that agent is already
49:40
cured. There's a lot of commercials out there, a lot of people promoting
49:44
they've cured agent, they've reversed aging, and people by the products galore.
49:49
And that's because there are people that are called writers our A G. T
49:54
O R s, which stanks for they're skilled at the art of persuasion.
50:00
Right now, I'm not. I can only tell the truth that one of
50:06
my past investors, when I used to have investors quoted me something that I
50:09
repeat all the time, and that hide behind the truth, and that's what
50:14
I do. I'm going to make some progress here, but doesn't aside.
50:22
I wish more people would behave like you in the world today, you know,
50:27
and particularly when we look at what's going on in our political environment and
50:30
at the moment, it's just so sad, you know, and we talk
50:35
about pessimism. So much of the pessimism I do believe comes from the inability
50:40
of people to be able to get along, to coexist. And you know,
50:45
when you say you're going to get canceled because you express your idea,
50:49
that's you know, that can create a pessimistic outcome because we're not allowing the
50:52
freedom to have interactions. So I'm all in your camp, you know,
50:59
hide behind the truth or be out in front of the truth, and don't
51:02
be afraid of the truth. That's that's what you know. I always tell
51:06
my staff, you know, consider the source whenever they say something and they're
51:12
you know, don't know where it came from, but they're just repeating something.
51:14
And I always tell them, you know, how do you know this
51:16
is true? And always stick with the fact. But you know, in
51:20
science, you have a you know, an analytical left brain, factual side,
51:23
but then you've got this right brain, you know, marketing, creative,
51:29
commercial, and there's a there's a bit of a battle, as you've
51:31
just said. And how do people, you know, like the investors,
51:36
how do they stay true to the science when we're really their end goal is
51:40
to make money. Yeah. I think there's a lot of billionaires out there,
51:47
multi billionaires, trillionaires that have all this money, and they they wonder
51:52
why nobody's cured aging yet, and they don't understand that that the people that
51:58
are investing in are controlling the science and keeping this sign getting done properly.
52:04
I mean when I used to have investors, I used to I felt like
52:07
we would have had aging cured over ten years ago if the investors hadn't taken
52:14
control, had had us to do other things instead. And then one day
52:19
when we were successful at everything and they announced they're going to sell the company.
52:22
I was very fortunate in the fact that I needed that one of those
52:27
investors was like minded with me and orchestrated a complete takeover the company. Buy
52:34
me, and he's still a business partner of minds MM. Now now we
52:40
don't get funding from traditional investing anymore. Funding from go to market partners that
52:46
are selling my discoveries that we made. We don't. We tell them we
52:52
don't have anything to do with marketing, we don't have anything to do with
52:53
testing all that, and then they do it, they make money and we
52:58
get a royalty and that funds are search right. So is there one?
53:02
Is there any one of those you want to talk about today to give us
53:05
a little idea of of I know you're not trying to be commercial, but
53:08
is there any any just allowing you to have a little bit of a promotional
53:14
moment. Is there anyone that you would like us to share with us?
53:21
Yeah, well let me say two of them. Okay, So I already
53:24
mentioned Touchdown Essentials. Yeah, and it's run by a guy named Eddie Stone.
53:30
Well, I think it's the most amazing person I've ever met in the
53:34
nutraceutical field. And that's why I'm working with He's not interested in profits,
53:40
He's very interested in being doing good things for humanity, and he wants to
53:46
see some products on the market that some products that are available to people that
53:51
really will make them helpy. I'm really enjoying more than I've worked with a
53:54
lot of multi level marketing companies and other kind of nutrial companies, but I've
54:00
never enjoyed working with Touchdown Essentials more than I have. I've never more whatever
54:08
enjoy more than any other company. They're the number one. And okay,
54:14
I got to make a note of him. Maybe I should invite him to
54:15
be on the podcast. Would he be receptable to I think so. I
54:20
think he would be okay, especially when he knows that I broke tradition and
54:25
mentioned his company's name. Right. I don't think that's going to hope.
54:30
That's not going to compromise any of the relationship. But I think it's really
54:32
valuable. And obviously they're not on the market yet, but they will be
54:37
shortly, as you said, right, But they do have other products.
54:39
In fact, Terrence Howard movie star Terrence Howard was interview and he all of
54:46
a sudden stops and takes some medicine or some squirt some stuff and his nose
54:52
or something like that, and he says, well, my wife said I
54:55
got to take this on the minute and not me. It not missing.
55:00
And the guy said, what is it? And he says, well,
55:04
I named the products, but he didn't. He didn't mention the touchdown essentials,
55:07
but he mentioned the product needs which were touched on essential products, and
55:10
they are good. I've never I mean, I've got some products sitting right
55:15
here that I take all the time. I'm sure I'm putting their company.
55:17
And believe me, I am not getting a penny for anything, right,
55:22
I understand, we understand, we know you're not that way. So that's
55:25
why the other company that if I'm going to mention Touchdown, I got to
55:29
mention one Truth eight one eight, which is a company in New Zealand that
55:35
is now has gotten testing done and now promotes a provides a skin care product
55:44
which understand that contains our most potent pharmaceutical that I said is only sixfold lower
55:50
than what is needed to reversation. They can't sell it as a supplement because
55:54
none of the countries have approved that it's for use yet. But safety studies,
56:00
efficacy studies, everything we're done for skin care products at a company called
56:05
Avage Labs in Italy, and now that's approved and it's available in New Zealand
56:12
and people can buy it in the United States. Oh, companies one Truth
56:15
eight one eight, those are those are my two favorite Okay, good,
56:22
well, you know you said them just in time, because we've run out
56:24
of time according to our little flag here about the podcasts that we have to
56:32
be religiously following because they have other podcasts after us, so we have to
56:38
go. But honestly, Bill, there's so much more I want to,
56:43
you know, want to explore with you. But I know every day there's
56:45
new things you're doing. And I'm going to put those two companies, if
56:50
you don't mind. I have Alexis, my assistant, put them in our
56:53
show notes so that people can follow up, and at least I'm going to
56:58
be one of the first to follow up. So thank you for indulging us
57:04
with that. Well, I will see you at podcast I mean at podcast
57:09
at Radfest, and we'll have a chance to chat there, I hope.
57:15
And are you going to be lecturing. Yes, I'm one of the main
57:17
main speak good. I saw you, I saw you do there. Okay,
57:22
good, all right, Well, thank you so much. I know
57:23
you had a sore throat and you've been doing a lot of zoom calls,
57:27
so thank you for hanging in there with us today, and we'll see you
57:32
in on September fifth. All right, thank you, all right, you
57:37
take care. Bye bye